An estimated 242,251 Canadians, and 150 million people worldwide are chronically infected with the hepatitis C virus, and more than 350 000 people die every year from hepatitis C-related liver diseases.1 Hepatitis C can lead to other serious diseases, such as liver failure, death, etc. But without any vaccines available to prevent the contraction of the disease, it may be hard to avoid. Due to disease generally being asymptomatic many people are unaware that they have it, further spreading the disease because of a lack of prevention mechanisms. Hepatitis C when developed chronically can cause serious affects on the liver, which may even lead to death. With hepatitis C being such a serious disease, it is important that more people be tested for it so they can start treatment in the early stages of the disease, as well as be aware and informed, before it becomes a chronic infection leading to serious complications.
Hepatitis C is a disease that is caused by the hepatitis C virus. This virus is a single stranded, enveloped, positive sense RNA virus.2
The viral RNA is highly mutable due to a lack of efficient proofreading mechanism while the virus replicates. This makes the virus undergo evolution with time, which ultimately because of the constantly changing virus, it manages to escape host’s immune system so it cannot identify and eliminate the virus effectively. Since the body cannot alone fight the virus, most people infected with hepatitis C go on to develop chronic infection. The hepatitis C virus works by attaching itself to a host cell, using particular proteins present to attach to a receptor site. The hepatitis C virus attaches to the receptor site on liver cells, which is why the liver is the organ that is primarily af...
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...eing administered due to its high rate of virologic response and milder side effects.
There are a number of ways that the current treatment for hepatitis C could improved. In the future researchers aim to develop a more effective, safe and well-tolerated interferon therapy. They have also created a new vaccine technology that has been tested in mice for its therapeutic efficiency against the most conserved regions of the hepatitis genome. They hope to eventually develop drugs that target the hepatitis C RNA-dependant RNA polymerase enzyme, which is responsible for the replication of the entire hepatitis C genome, and prevent the replication of the hepatitis C virus directly.9 Although hepatitis C is a very serious disease of the liver, technologies and medications have been proven to be effective in many chronically infected persons with hepatitis C virus.
The virus is primarily spherical shaped and roughly 200nm in size, surrounded by a host-cell derived membrane. Its genome is minus-sense single-stranded RNA 16-18 kb in length. It contains matrix protein inside the envelope, hemagglutinin and neuraminidase, fusion protein, nucleocapsid protein, and L and P proteins to form the RNA polymerase. The host-cell receptors on the outside are hemagglutinin and neuraminidase. The virus is allowed to enter the cell when the hemagglutinin/ neuraminidase glycoproteins fuse with the sialic acid on the surface of the host cell, and the capsid enters the cytoplasm. The infected cells express the fusion protein from the virus, and this links the host cells together to create syncitia.
HAV is known to be an infectious disease that usually occurs in children and young adults .The disease is usually transmitted from person to person through contaminated food, liquids or oral fecal route. An example would be when someone is carrying the virus and doesn’t wash their hands after using the restroom and then puts food in their mouth. HAV is most common in developing countries because of the living conditions and inadequate water, poor sewage facilities and sanitary conditions. The highest HAV levels in the world are from India,” Earlier reports suggest that India is hyperendemic for HAV infection2,4-6 with very high infection rates,” (Sowmyanarayanan). Most HAV are without severe complications, “Virus HAV infection rarely causes fulminant hepatic failure in people…,” (Vento,p.1) . The symptoms for HAV are high fever, nausea, vomiting and jaundice...
Hepatitis B is a DNA viral infection that causes damage and inflammation to the liver. It was first discovered in 1965 by Dr. Baruch Blumberg. The HBV virus is very contagious and is even thought to be the most serious form of viral hepatitis and the most common viral infection on Earth. “HBV is 100 times more infectious than HIV.” (Green, 2002, pg. 7) The virus can survive for about one week outside the body on a dry surface. According to Green (2002, pg. 7), “One in twenty Americans has been infected with the virus at some point in their lives.” Between the ages of 15-39 is when 75% of new HBV infections occur, according to Green (2002, pg.8).
The signs and symptoms of blood borne pathogens vary based on the type of disease it is and the ability of a person’s immune system to fight it off. In most cases hepatitis B does not need to be treated and the body can fight it off on its own. However a long-term infection can develop in some people that can cause liver damage. There is a vaccination available to prevent acquiring the disease. The signs and symptoms for hepatitis C are usually mild. It can take two weeks to six months after contact before signs begin to show, or there may not be any symptoms at all. Hepatitis C typically becomes is a long-term infection and after many years will cause liver ...
Acute HBV infection is the most common type of infection in low endemic countries. The incubation period, from transmission to clearness, ranges from 40-180 days. The infection is either symptomatic or asymptomatic/ fulminant hepatitis. Children under the age of 5 years rarely experience symptomatic infection (10%), where’s about 30-40% infected adults and children above age 5 experience a symptomatic infection with yellowing of skin and teeth, vomiting, fatigue, laxity and abdominal pain [1].
Liver disease resulting from alcohol affects more than two million Americans and is one of the primary causes of illness and death. The liver frees the body of harmful substances, such as alcohol. While the liver breaks down alcohol, it produces toxins that can be even more dangerous than the alcohol consumed (“Beyond Hangovers: Understanding Alcohol's Impact on Your Health” 13). “These by-products damage liver cells, promote inflammation, and weaken the body’s natural defenses. Eventually, these problems can disrupt the body’s metabolism and impair the function of other organs” (“Beyond Hangovers: Understanding Alcohol’s Impact on Your Health” 13).
Hepatitis A is a usually short-acting virus that occurs in humans and monkeys. It is caused by the Hepatovirus and the species is Hepatitis A Virus. There are two major ways in which hepatitis A can be transmitted. One way is from person to person. This transmission occurs when the fecal matter of an infected person gets ingested by another person.
Hepatitis A is an acute infection of the liver that travels through your bloodstream and gastrointestinal tract (2). It is transmitted person to person through fecal contamination. Ingesting contaminated food and water is the main source, this usually occurs when an infected food handler prepares food without appropriate hand hygiene (3). Outbreaks are fairly common in institutions, prisons and military forces. An early infection of Hepatitis A can mimic the flu with symptoms such as being febrile, lethargy, nausea, anorexia, abdominal discomfort and eventually causing severe jaundice (1). This virus can progress and cause liver failure and even death if not treated promptly (3).
Influenza is a major public health problem which outbreaks all over the world. Resulting in considerable sickness and death rates. Furthermore, it is a highly infectious airborne disease and is caused by the influenza virus. Influenza is transmitted easily from one person to another person which has a great impact on society. When a member of society becomes sick, it is more prone to spread to other people. In the United States, every year between 5 to 20 percent of the population is affected by influenza. As a result of this, between 3,000 and 49,000 deaths have occurred per year (Biggerstaff et al., 2014). Therefore, the influenza vaccine is the most effective strategy to prevent influenza. This essay will examine two significant reasons for influenza vaccination which are the loss of workforce and economic burden as well as one effect regarding herd immunity.
The primary cause of hepatic cirrhosis in the United States is long-term alcoholism. Men respond differently than women to alcohol. With women one or two drinks a day can cause them liver damage. Men can consume two to five drinks a day and be ok. One drink a day can create liver scarring. So like everything else in life it varies, it might affect everyone differently. The individual who drinks alcohol on a daily basis, or more often then others have a higher risk of developing cirrhosis. Hepatic cirrhosis has also been linked to serious liver infections such as hepatitis B and hepatitis C. Patients who are HIV positive have died from developing cirrhosis through the hepatitis virus. Other causes of cirrhosis come from reactions to prescribed medications, injuries to the liver, exposure to toxic substances, and episodes of heart failure with liver congestion. Obt...
There is a disease spreading out in the world called Hepatitis C. It affects the liver and may cause the liver to fail. This disease is caused by a virus called Hepatitis C virus which is also known as HCV. About 32,000 people are affected with this disease per year only in the United States area. Some It’s a disease with many symptoms and many causes. of these symptoms are easy bruising, upset stomach and fever. These are just some of the many symptoms that come from the virus. Hepatitis Cs nature of the causative agent is determined by many things. The biological data of this disease is filled so much information. It is estimated that over 180 million people have gotten Hepatitis C and it is growing.
This case study is about Abdul Chidiac, a 51 year old male, married with 4 children. He had a medical history of hypertension, hypercholesterolaemia and cirrhosis with two admissions in the last six months. He is a smoker and drinks beer, 5-6 bottles per day. As Carithers & McClain (2010) explained the patient’s medical history is another indicator of the risk for cirrhosis; the progression to cirrhosis is adaptable and may take time over weeks or many years. Cirrhosis is a liver disease characterized by permanent scarring of the liver that interferes with its normal functions including alcoholism. Most people who drink large amounts of alcohol cause harm to the liver in some way (Heidelbaugh & Bruderly, 2006). The cause of cirrhosis is not yet known, but the connection between cirrhosis and excessive alcohol ingestion is established (Jenkins & Johnson, 2010). Common causes of cirrhosis include: alcohol abuse, hepatitis B infection, hepatitis C infection and non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (Schuppan & Afdhal, 2008).
Virus- An infectious agent found in virtually all life forms, including humans, animals, plants, fungi, and bacteria. Viruses touch us every day through water, food, physical contact, blood, animals, or even, the air you breathe. Although most are harmless, there are some that are not.... ...
It is a virus AIDS is a fatal disease which renders the body helpless against other diseases. Patients lose the ability to defend themselves against viri. and die from infections.
Alcohol in the form of alcoholic beverages has been consumed by humans since pre-historic times, for a variety of hygiene dietary, medicinal, religions and recreational reasons. According to the NIH Senior Health, drinking too much alcohol affects many parts of the body. It can be especially harmful to the liver, the organ that metabolizes (breaks down) alcohol and other harmful substances. People who drink heavily for a long time can develop diseases such as liver inflammation (alcoholic hepatitis) or severe liver scarring (cirrhosis). Alcohol-related liver disease can cause death. According to the statistics in the year 2010 by the CDC (Centers for Disease Control and prevention) the number of discharges with chronic liver disease and cirrhosis as the first-listed diagnosis was 101,000 persons, while the number of deaths has been 31,903 persons.