Acute Kidney Injury Research Paper

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Acute renal failure also known as acute kidney injury occurs when there is a sudden decline in kidney function. During acute renal failure there is also an elevation in plasma creatinine and blood urea nitrogen level as there is a decrease in glomerular filtration and an accumulation of nitrogenous waste products in the blood (Huether & McCance, 2012, p. 754). The level of kidney injury is classified and diagnosis by using the acronym RIFLE. RIFLE stands for risk, injury, failure, loss and end-stage kidney disease. The three stages of kidney injury are renal insufficiency, renal failure, and end-stage renal failure. Renal insufficiency is when there is a 25% decline in renal function or when the glomerular filtration rate (GFR) is 25 to 30 …show more content…

This includes extracellular volume depletion, decreased renal blood flow, and/or injuries to the kidney cells. Acute kidney injury can be classified as pre-renal, intra-renal, or post-renal. Causes of pre-renal are due to hypovolemia, hypotension, or hypo-perfusion. Of these the most common cause of acute kidney injury is due to renal hypo-perfusion. Poor profusion can lead to vasoconstriction, hypotension, hypovolemia, hemorrhage, and inadequate cardiac output (Huether & McCance, 2012, p 754). When the body fails to restore blood volume or blood pressure, cells injury can occur and cause acute tubular necrosis or acute interstitial necrosis. Causes of intra-renal dysfunction are due to acute tubular necrosis from post-ischemic or nephrotoxic causes. Acute tubular necrosis can be caused by glomerulopathies, acute interstitial necrosis, vascular damage, malignant hypertension, coagulation defects, renal artery/vein occlusion, and bilateral acute pyelonephritis (Huether & McCance, 2012, p. 755). Post-renal injury is rare and is due to urinary tract obstruction, tumors, or neurogenic bladder that affects the kidneys bilaterally (Huether & McCance, 2012, p.

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