Bioactivity and Drug Delivering Ability of a Chitosan/46S6 Melted Bioactive Glass Biocomposite Scaffold

Bioactivity and Drug Delivering Ability of a Chitosan/46S6 Melted Bioactive Glass Biocomposite Scaffold

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3.3.2 XRD analysis and FTIR after immersion in SBF
The XRD of the prepared scaffolds after soaking in SBF for different time intervals is demonstrated in Fig. 6. XRD spectra of Ch/MB composite scaffolds showed sharp peaks, 25.88°, 31.8°, 39.89° and 46.7° (2θ) attributed to 022, 211, 221 and 222 reticular planes of HA [30, 31]. The increase in the intensity of peaks from 2 days to 30 days was indicative of the increase in the deposition of HA. It also confirmed that the presence of MB increased the deposition of HA on the scaffolds [32] (Fig. 6). The IR spectrum of synthetic hydroxy apatite was used as references to evaluate the structural evolution and the bioactivities of the prepared scaffolds [33]. After soaking in SBF solution, the initial characteristic bands of the Ch/MB biocomposite are modified strongly because of the interfacial reactions between scaffolds and the SBF. Consequently, the spectra of these biomaterials reveal new bands as demonstrated in Fig. 7.
In detail, the spectrum of Ch/MB biocomposite shows three new, well-defined phosphate bands at 565, 603 and 1039cm–1 after 2 days of soaking in physiological solution for Ch/MB scaffolds. They are assigned to stretching vibrations of the PO4 3– group in phosphate crystalline phases. This result confirms the formation of a calcium phosphate layer; this spectrum is quite similar to that of hydroxyl apatite except for the two bands located at 1620 and 3423 cm–1. These bands are characteristic of the presence of water related to the hygroscopic feature of the apatite formed. In addition, the carbonate band at 1420 cm–1 is also observed. This band attributes to a stretching vibration of the C−O liaisons in carbonate groups. The presence of carbonate bands indicates the f...

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