St John's Wort Research Paper

(1) St. John’s wort

Hypericum perforatum is a botanical name of St John's wort. It belongs to a family of Clusiaceae or Hypericacacae. Hypericaceae or St. John's wort family or Clusiaceae is one and same thing. It is a flowering plant species of the genus Hypericum and a medicinal herb that is sold globally and good treatment for major depressive disorder {1, 2}.It has been demonstrated by various studies which conclude that st. john's wort is generally as useful against depressions as other modern medication, again with lesser side effects, and it is usually approved for depression in Europe. Conversely, a new study revealed that st. John’s wort is no more useful than a placebo in cases of acute depression (Hypericum depression trial study group, 2002). It is a little, weedy shrub that is cultivated in warm climates .Though it tastes quite bitter, all parts of the plant, bud, stem, and leaves can be used as an herbal medicine for depression. With this inviting plant so many people prefer to treat their depression .So there are various clinicians and researchers who have skepticism that this product of nature can truly be as helpful in curing

Higher amount of serotonin should also be checked and monitored every interval of time, when using hypericum with SSRIs, tryptophan, or 5-hydroxytryphan. Symptoms of “serotonin syndrome ‘’ can be due to more uses of this particular extract, as per U.S. Food and Drug Administration, It is as a result of overcapacity of serotonin on the (CNS) central nervous system and (PNS) peripheral nervous system .Some researchers says it is also called serotonin toxicity or serotonin toxidrome which more precisely reveals that it is a type of poisoning. There are some other names for it which comprises of serotonin sickness, serotonin storm, serotonin poisoning, hyperserotonemia, or serotonergic