Alzheimer’s disease is a deadly progressive form of atrophy that affects millions of people around the globe. Alzheimer’s disease also referred to as AD accounts for 70% of dementia cases diagnosed. Two significant reasons linked to the development of AD are genetic influences and lifestyle/environmental factors, while two of its primary effects are death of nerve cells and tissue loss within the brain as well as interference in the patient’s daily life.
One of the main causes for Alzheimer’s is the genetic component related to family bloodlines. Genes manipulate the function of every cell in our bodies, including basic characteristics and potential disease development. The genes that determine potential disease development can make someone more prone to developing Alzheimer’s. The gene that is associated with AD is called apolipoprotein E, also referred to as APOE; there are three different types of APOE, but only one has been shown to increases the risk of AD, it is referred to as APOE e4. We each inherit an APOE form our mother and fathers, having even one APOE e4 gene increases the risk of developing AD. If a patient has two APOE e4 genes, the risk is even greater. In an article titled Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, the authors Corder, Saunders, Strittmatter, Schmechel, Gaskell, Small, Roses, Haines, Pericak-Vance (1993) state, “The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD).” (p. 921). The APOE e4 gene was identified so long ago and its association with AD is a major risk that I feel should be considered by potential parents. Even though g...
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...ders, A., Strittmatter, W., Schmechel, D., Gaskell, P., Small, G., et al. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 261(5123), 921-923.
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The sixth leading cause of death in the United States, Alzheimer’s disease afflicts approximately 5.2 million persons age 65 and over (Alzheimer's Association, 2012). Rapid growth of the older population as the Baby Boomer generation ages will cause unprecedented increases in the number of individuals with Alzheimer’s. It is estimated that by 2025 the number of Wisconsin residents with Alzheimer’s age 65 and older will increase by 30% to a projected total of 127,000 (Alzheimer's Association, 2012).
Stem cells are a type of unspecialized cells that can revive themselves through the process of cell division (Abdel-Salam and Oma, 2011). They have a phenomenal potential to differentiate into other specific cell types in a living organism. These cells can also be activated to turn into organ-specific cells or tissues with defined activity but only under specific experimental set-up. Stem cells have the ability to remain as they are or divide further to renew deteriorated and damaged tissue cells. Recently it has been discovered that stem cells can be used to treat Alzheimer’s disease but still a lot of clinical trials are being conducted to find a specific government approved treatment. Alzheimer’s disease is the most common cause of dementia. The very first stages of Alzheimer’ include symptoms like confusion and using the right words while talking. As it gets on to later stages symptoms like loss of memory and mood swings start to appear (Begley et al., 2001). Any sort of stem cell treatment is not available to Alzheimer’s patients yet as researchers are still conducting new experiments. There are multiple neurons that get damaged by Alzheimer’s which makes the problem even more complex and different approach needs to be followed every time a clinical trial is conducted.
Nerve cell death and tissue throughout the brain is the most significant affect over time. Naturally by age twenty-five the brain starts to decrease in size. With Alzheimer’s, the amount decrease is extremely significant. The cortex begins to shrivel up which is the part of the brain required for planning, remembering, and thinking. The most noticeable shrinkage occurs in the hippocampus. The hippocampus is responsible for the formation of new memories, it is also located inside the cortex. Upon further inspection under microscope, tissue samples are observed and synapses and nerve cell count is severely decreased. Tangles, are also found which our twisted strands of another protein due to nerve cells dying and bunching together. Plaques and tangles are prime suspects in the death and tissue loss in the Alzheimer’s brain. Beta-amyloid is a chemical and is sticky which causes it to gradually build up into plaques. This chemical derives from a larger protein found in the nerve cells with fatty membranes. These tangles destroy a vital cell transport system made of proteins.
of diagnosis is about 80 years old (Johnson, 1989). The incidence is about the same for all races, but women are more likely than men to develop the disease, because they live longer. The second factor is heredity. Family history plays a role in about forty percent of people with early onset of Alzheimer’s (Johnson, 1989). If your parents or a sibling developed the disease, you are more likely to, as well. But there are cases of families with several people who have had this disease and other members are not affected. These two factors are the only proven factors, but environmental research is being done to help with a possible protective effect for the disease. As of now, more research is needed to confirm any be...
Alzheimer’s disease got its name from the German doctor, Dr. Alois Alzheimer. In 1906, he noticed that there were abnormal clumps and bundles of fibers i...
“Alzheimer's disease is a progressive, degenerative disorder that attacks the brain's nerve cells, or neurons, resulting in loss of memory, thinking and language skills, and behavioral changes” (Alzheimer’s Foundation of America, 2014). AD is a debilitating disease that interferes with the individual’s quality of life and often causes distress to the loved ones around them. The cause of AD is unknown; however, there are some factors that put individuals at risk for developing AD such as: age (gre...
Alzheimer’s disease, named after Dr. Alois Alzheimer, is a disease that is on the rise in America and the rest of the world. People should learn as much as they want about this disease, because as you age, your chances of becoming an Alzheimer’s Disease, or AD, patient increases. It is estimated that approximately 3 percent of Americans between the ages of 65 and 74 have the illness, and more than half of all people over age 85 have the ailment.
Alzheimer’s disease (AD) is one of the leading causes of death in America and there are currently more than five million people living with the disease (Alzheimer’s Association, 2014). What may be most troubling about these numbers is the fact that Alzheimer’s disease has no current cure. Alzheimer’s disease is a neurocognitive disorder and a common form of dementia that will affects a person’s memory, way of thinking and their behavior (Alzheimer’s Association, 2014). AD typically develops slowly and the more time a person has the disease the worse the symptoms will become. AD in its later stages becomes so severe that people with the disease cannot even do simple daily tasks. Although there is no cure there are still ways to prevent, delay, and possibly treat the disease.
Alzheimer's disease is the most common form of dementia, and this terminal, progressive brain disorder has no known cause or cure. Its greatest known risk factor is increasing age which is why is it is infamous for developing in the elderly, typically in ages 65 or over, however for the 5%(1) that develop Alzheimer’s in their 40s or 50s it is known as early Alzheimer’s. Because Alzheimer’s worsens over time, those with it tend to struggle with completing daily tasks especially elderly people. Given that there is no cure for Alzheimer’s, the treatments available slow the worsening of dementia symptoms and improve quality of life for those with Alzheimer’s and their caregivers. It is not known what causes Alzheimer's, however, those with Alzheimer's have been found to have abnormal amounts of protein (amyloid plaques) and fibres.(The amyloid plaques and fibres are found in regions of the brain where problem solving and thinking take place e.g The cerebrum.) Due to the unusual amounts of amyloid plaques and fibres, it reduces the effectiveness of healthy neurons and eventually, destroying them.
Alzheimer’s disease (AD) is a progressive, terminal, degenerative brain disease. It is the fourth leading cause of death in adults and currently affects over four million people in the United States. This number is expected to increase over the next several years as the baby boomers age, until it reaches fourteen million by the year 2025.
Thesis/Preview Statement – Alzheimer’s disease (AD) causes a decline in brain function, it destroys healthy nerve cells. Today, we have discussed Causes, Symptoms, and Diagnosis of AD.
...hed and streamlined to allow for earlier diagnosis. In the case of tertiary prevention, the pharmaceutical companies have a huge financial incentive to create a cure for Alzheimer’s but that is not enough. More government funded research should be dedicated towards finding methods to delay or cure Alzheimer’s disease. The baby boomer generation has already entered their 60’s. As people live longer, as a result of new treatments for common killers such as heart disease and cancer, the chances that they will succumb to Alzheimer’s increases. Failing to find preventative or curative measures will be costly. On a personal level, Alzheimer’s disease slowly attacks cognitive function-the higher thought processes; individuals degenerate into infantile dependents. The cost of caring for increasing numbers of such dependents will be a burden on both family and society.
Cummings, Jeffrey L., Cole, Greg. “Alzheimer Disease.” Journal of the American Medical Association. May 2002: 287-18. Health Source. EBSCOhost. Utica College Lib. 15 Apr 2005. .
Kamphuis, P. H., & Scheltens, P. (2010). Can nutrients prevent or delay onset of alzheimer's disease?. Journal of Alzheimer's Disease, 20(3), 765-775. doi:10.3233/JAD-2010-091558
Alzheimer’s Disease is named after a German doctor, who specializes in the brain and nervous system, named Alois Alzheimer. This Disease forms in the brain. Alzheimer’s is the most common form of Dementia, a general term for memory loss and other intellectual abilities serious enough to enter. The Tau protein ensures the tubes in your brain stay straight allowing molecules to pass through freely. In Alzheimer’s Disease the protein collapses into strands or tangles, making the tubes disintegrate. There is visible differences of brain tissue in the from misfolded proteins called plaques and tangles. Beta-Amyloid clumps block signals and communication between cells in the brain. Researchers agree that Alzheimer’s Disease is m...