One of the main causes for Alzheimer’s is the genetic component related to family bloodlines. Genes manipulate the function of every cell in our bodies, including basic characteristics and potential disease development. The genes that determine potential disease development can make someone more prone to developing Alzheimer’s. The gene that is associated with AD is called apolipoprotein E, also referred to as APOE; there are three different types of APOE, but only one has been shown to increases the risk of AD, it is referred to as APOE e4. We each inherit an APOE form our mother and fathers, having even one APOE e4 gene increases the risk of developing AD. If a patient has two APOE e4 genes, the risk is even greater. In an article titled Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, the authors Corder, Saunders, Strittmatter, Schmechel, Gaskell, Small, Roses, Haines, Pericak-Vance (1993) state, “The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD).” (p. 921). The APOE e4 gene was identified so long ago and its association with AD is a major risk that I feel should be considered by potential parents. Even though g...
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...ders, A., Strittmatter, W., Schmechel, D., Gaskell, P., Small, G., et al. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 261(5123), 921-923.
Pope, S. K., Shue, V. M., & Beck, C. (2003). WILL A HEALTHY LIFESTYLE HELP PREVENT ALZHEIMER'S DISEASE?. Annual Review of Public Health, 24, 111-113.
Lassmann, H., Bancher, C., Breitschopf, H., Wegiel, J., Bobinski, M., Jellinger, K., et al. (1995). Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathologica, 89(1), 35-41.
Mckhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS- ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34(7), 939-944.
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