Mitochondrial Dysfunction and Chronic Disease
A rapidly developing science of mitochondrial medicine reveals that there are many conditions that arise from mitochondrial dysfunction. These mitochondrial cytopathies are due to the mitochondria's inability to completely convert food and oxygen to energy.
According to the Mitochondrial and Metabolic Disease Center, which specializes in mitochondrial disease research and treatments, more than 1 in 4,000 children born in the US yearly will develop a mitochondrial disease by the age of 10 years. One example is Leigh's syndrome, which is a severe neurological dirorder that affects infants. Other develop mitochondrial myopathies, which affect the muscles and nerves, before reaching their second decade of life. Among adults, mitochondrial dysfunction is often linked to age-related conditions such as type 2 diabetes, cancer, heart disease, Parkinson's disease, and more.
Research in mitochondrial disease dates back to the 1940s and the first diagnosis of a disorder related to mitochondrial dysfunction was in 1959. Research...
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Finsterer J. Hematological Manifestations of Primary Mitochondrial Disorders. Acta Haematol 2007;118:88–98.
The Mitochondrial and Metabolic Disease Center brochure. http://www.ucsdbglab.org/mmdc/brochure.htm
Unlocking a Major Cause of Disease. http://drdanielclark.com/drdc/Mitochondria.html
Marriage B, Clandinin MT, and Glerum DM.Nutritional cofactor treatment in mitochondrial disorders. J Am Diet Assoc. 2003;103:1029-1038. http://www.journals.elsevierhealth.com/periodicals/yjada/article/S0002-8223%2803%2900476-0/abstract.
Walters A, Poter G, and Brookes P. Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy. Circulation Research. 2012; 111: 1222-1236. http://circres.ahajournals.org/content/111/9/1222.full
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