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Ethical and moral issues on gene therapy
Ethical dilemmas of gene therapy
Ethical and moral issues on gene therapy
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When in 1904 Avery (OT Avery 1877 ~ 1955)’s the pneumococcus transformation experiments firstly found that DNA is the carrier of genetic information. (Baruch S, Huang S, Prichard D, et al., 2005) Many gene-related academic subjects have poured out. Through them, gene therapy which has the closest link with human’s lives is the most controversial subject. Although gene therapy gives us hope of many diseases which seems impossible to be cured before, but the drawbacks of gene especially the cons from ethical like the death caused by gene therapy, the evolution problems caused by DNA exchange and the censorship of the experiment of gene therapy. As a result, whether to continue developing gene therapy need to be cautious.
Admittedly, the technology of genetic therapy does bring hope to some diseases like lung cancer which are considered as incurable disease. There are also some successful medical examples. In 2006, the U.S. National Cancer Institute found a way to identify and attack cancer cells by changing the genes of patient's immune cells. After the first clinical trials, two patients with advanced melanoma skin cancer have been cured. (Baruch S, Huang S, Prichard D, et al., 2005) Coincidentally, in 2008, the scientists in German found that hemophilia and other genetic diseases can be cured in theory through gene therapy. (Baruch S, Huang S, Prichard D, et al., 2005) The most important advantage of gene therapy is that the disease once has been cured by gene therapy will have very low possibility to relapse. That is because all the species on the earth follow the principle of base pairing. So the genes of the nucleus has nearly no odds to produce rejection (Rifkin, J., 1993).
Although it is true that some successful ex...
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It was in the 1980’s that scientist began looking at alternative ways of treatments, one is gene therapy. Scientist would insert human genes into a bacteria cell. Then the bacteria cell would transcribe and translate the information into a protein. Once that is done the scientist would then introduce the protein into human cells. Gene therapy can be simply viewed as inserting bits of foreign DNA into a patient’s tissue in hope...
Over 40 years ago, two men by the names of James Watson and Francis Crick discovered deoxyribonucleic acid, or DNA. DNA is hereditary material in humans and almost all other organisms (What is DNA?). From this finding, gene therapy evolved. Today, researchers are able to isolate certain specific genes, repair them, and use them to help cure diseases such as cystic fibrosis and hemophilia. However, as great as this sounds, there are numerous ethical and scientific issues that will arise because of religion and safety.
Gene therapy gives people who suffer from genetic diseases a chance to lead a normal life. Dangerous diseases, such as AIDS, SCID, Thalassemia and ADA can be cured successfully. In September 5, 2006, two people with advanced melanoma received Gene therapy and they got recovery soon. This is a breakthrough in cancer gene therapy. Gene therapy uses patients own cells to cure diseases, and, therefore, no rejection to their bodies. Furthermore, patients could get permanent cure from gene therapy without recurrence.
"The aim is to decrease the fear of a brave new world and to encourage people to be more proactive about their health. It [Gene therapy] will help humans become better physically and even mentally and extend human life. It is the future” (Hulbert). Dr. Hulbert, a genetic engineer, couldn’t be anymore right; more time, money, and research needs to be put into gene therapy and genetic engineering, since it can cure certain illness and diseases that are incurable with modern medicine, has fewer side-effects than conventional drugs or surgery, and allows humans to be stronger physically and mentally at birth. Gene therapy or genetic engineering is the development and application of scientific methods, procedures, and technologies that permit direct manipulation of genetic material in order to alter the hereditary traits of a cell, organism, or population (NIH). It essentially means that we can change DNA to make an organism better. Genetic engineering is used with animals and plants every day; for example with genetic...
Indian society was patriarchal, centered on villages and extended families dominated by males (Connections, Pg. 4). The villages, in which most people lived, were admini...
In 2000 the United Nations Populations Fund (UNFPA) defined reproductive rights as "the basic rights of couples and individuals to decide freely and responsibly the number, spacing and timing of their children; to have the information and means to do so; and to have the right to make decisions concerning reproduction, free of discrimination, coercion or violence."[1] Traditionally society defines reproductive rights in the context of one's being able to make decisions about his or her own reproduction; other individuals, unrelated to that person, were not considered as being involved in the decision. With the onset of in vitro fertilization (IVF) in 1978, reproductive processes have become more complicated. For example, in gestational surrogacy a surrogate mother, not genetically related to the embryo, is brought into the process of reproduction. This technique allows infertile couples to carry a child or children in the womb of a carrier, rather than in the womb of the biological mother.[2] As a result of this ethically controversial technology, society must modify its reproductive rights. In vitro fertilization (IVF) alone will not solve people's reproductive problems and protect everybody's rights. Society, therefore, must distinguish whose rights-the rights of biological parents or those of the surrogate mothers-should be protected.
One of the most necessary uses of genetic engineering is tackling diseases. As listed above, some of the deadliest diseases in the world that have yet to be conquered could ultimately be wiped out by the use of genetic engineering. Because there are a great deal of genetic mutations people suffer from it is impractical that we will ever be able to get rid of them unless we involve genetic engineering in future generations (pros and cons of genetic eng). The negative aspect to this is the possible chain reaction that can occur from gene alteration. While altering a gene to do one thing, like cure a disease, there is no way of knowing if a different reaction will occur at the cellular or genetic level because of it; causing another problem, possibly worse than the disease they started off with (5 pros and cons of gen. eng.). This technology has such a wide range of unknown, it is simply not safe for society to be condoning to. As well as safety concerns, this can also cause emotional trauma to people putting their hopes into genetic engineering curing their loved ones, when there is a possibility it could result in more damage in the
Coker, Jeffrey Scott. "Genetic Engineering Is Natural and Should Be Pursued." Genetic Engineering, edited by Noël Merino, Greenhaven Press, 2013. Opposing Viewpoints. Opposing Viewpoints in Context,
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
Human Genetic Engineering: Designing the Future As the rate of advancements in technology and science continue to grow, ideas that were once viewed as science fiction are now becoming reality. As we collectively advance as a society, ethical dilemmas arise pertaining to scientific advancement, specifically concerning the controversial topic of genetic engineering in humans.
Pray, Leslie A., Ph.D. “Embryo Screening and the Ethics of Human Genetic Engineering.” Nature.com. Nature Publishing Group, 2008. Web. The Web.
Gene therapy enables patients to survive incurable diseases. In the field of genetic diseases, ADA-SCID, CGD and hemophilia are three main ones. ADA-SCID is known as the bubble boy disease. CGD is related to immune system that would lead to fungal infections which are fatal. Patients with Hemophilia are not able to induce bold bleeding (Gene therapy for diseases, 2011). Gene therapy also has good effects on cancer treatment and neurodegenerative diseases, which include Parkinson’s disease and Huntington’s disease. Viral infections, including influenza, HIV and hepatitis can also be treats by it (Gene therapy for diseases, 2011). According to the Science Daily in 2011, gene therapy now can apply to heart failures and neurologic diseases as well.
Due to the fact that the field of biotechnology is very serious and potentially dangerous, rules must be set down in order to keep the research in check. The high risk research of genetic therapy needs guidelines that have to be followed in order to keep the study just. The articles that are discussed in this essay focus on ethical issues and ideas that should be followed in the field in order to keep research safe and valid.
There are different ways and reasons why people wish to change the genes in their cells; the two categories split into “somatic and germline genetic engineering”. When a scientist uses “somatic genetic engineering” -the sex cells-- eggs and sperms are not affected; a specific gene code is changed and the genes do not pass down to the next generation. The other genetic engineering used is “germline” which, in contrast to somatic engineering, affects the eggs and sperms. When germline genetic engineering is used, the genes will be passed down to the next generation, affecting the physical and genetic traits. The debate rises and people question people’s free will. Bioethics is the formal and recognized term that describes the advantages and disadvantages that genetic enginee...
The current manifestations of the caste system are now far more generalized across the Indian subcontinent than was the case in former times. Caste as we now recognize has been endangered, shaped and perpetuated by comparatively recent political and social developments. This is evident even i...