The prevalence of DM has rapidly increased in the US and worldwide over the past decade. Almost 26 million US adults have DM with 9 millions Americans aged 20 or older with prediabetes. It is projected by 2050, nearly 50 million Americans will have Diabetes. More than 1/3rd of US adults are obese, putting them at increase risk for the same. Hence healthy people 2020 goals include reduction of obesity in an effort to lower the incidence and complications of DM in the US population( 1st article – 2)
Type 2 DM in low – normal weight adults with BMI < 25 has been gaining much interest lately. It is an understudied representation of metabolically obese normal weight phenotype. In this review article we will focus on the lean ketosis resistant diabetes
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Early reports of KRDY emphasized the association with malnutrition, as wasting or underweight was noted in 25-50% of patients. Under-nutrition at presentation could reflect in part the effects of long standing glycosuria, and may improve if insulin treatment in maintained in the presence of relatively poor protein-calorie intake. Alemu et al.. and colleagues have described the phenotype of more insulin requiring patients in 2 regions of Ethiopia as follows: lean, poor, peak age at diagnosis being approximately 25 years with male preponderance and no clinical evidence of structural pancreatic abnormalities. This phenotype resembles previous descriptions of KRDY form rather than classic Type 1 …show more content…
In this study, there were no significant differences in the age of diagnosis (45+/-10) or the duration of Diabetes between the three study groups. Male preponderance was noted in both lean and ????? B group. There was no significant differences in the smoking pattern between the 3 groups. This study also demonstrated that the HbA1c, fasting & postprandial blood glucose was higher in the lean group. Retinopathy was more frequent among the lean NIDDM in both genders. Additionally renal insufficiency and neuropathy were more common among lean male NIDDM patients. The higher prevalence of these complications were concluded to be related to the higher plasma glucose and HbA1c. One limitation of this study was that C-peptide, GAD antibodies and islet cell antibodies were measured only in a very small number of patients who were studied, thereby leaving a chance that the so-called “lean-NIDDM: patients may be in reality( or may have included) patients with IDDM. But all patients who had an abrupt onset of Diabetes, acute weight loss, ketosis or ketoacodisos at any time or required insulin from the time of diagnosis were classified as IDDM and were excluded from the study. In addition the patients under, 'lean diabetes' group has C-peptide values,
Type 1 diabetes mellitus also known as juvenile diabetes is a serious condition in which the pancreas produces a small amount or no insulin at all. Insulin is a hormone the body needs to transfer sugar into cells to create energy. This disease is most common in children, but can occur in adults around their late 30’s to early 40’s. Unlike patients with type 2 diabetes, type 1 diabetes patients are not usually overweight.
Case study: Carol is 17 years old and was diagnosed with Type 1 diabetes at the age of 7 years. Carol has had a recent hospital admission for dehydration and high blood glucose. During the admission Carol was found to be 6 weeks pregnant. Prior to the admission she had been experiencing weight loss and changes in mood.
According to Lewis and associates, DM is a chronic disease that affects multiple body systems. For the purpose of this paper, only DM type 2 will be discussed based on the assumption that a majority of patients aged 60 years or older have this type. The primary defects of this disease consist of insulin resistance, decreased insulin production, inappropriate glucose production by the liver, and alterations in production of adipokines. Insulin resistance is the result of defects in the body’s insulin receptors. This finding predates all cases of DM type 2 and the development of impaired glucose tolerance. In insulin resistance, beta cells in the pancreas are stimulated to increase insulin production to compensate for the lack of response by the insulin receptors. Gradually, the beta cells begin to fail to secrete enough insulin to meet the body’s demands resulting in hyperglycemia. As a result of increased glucose in the liver, the liver begins to malfunction and release glucose at inappropriate times, thereby worsening hyperglycemia. Adding to the problem, glucose and fat metabolism is altered in adipose tissue, which is generally abundant in those with DM type 2. (Lewis et al., 2011)
Obesity remains an extremely serious issue worldwide. Once considered a problem for wealthier counties, overweight and obesity are now dramatically increasing in low and middle income countries (WHO, 2011). In American, the rates of obesity continue to soar. CDC (2009) recognizes obesity as a risk factor for diabetes, heart disease, high blood pressure, and other health problems. According to NHANES over two-thirds of the US are overweight or obese, and over one-third are obese (CDC, 2009). Treatment for this illness varies; it may include the incorporation of diet, exercise, behavior modification, medication, and surgery. Since there is no single cause of all overweight and obesity, there is no single way to prevent or treat overweight and obesity that will help everyone (CDC, 2009).
Diabetes is a disease in which a person’s body in unable to make or utilize insulin properly which affects blood sugar levels. Insulin is a hormone that is produced in the pancreas, which helps to regulate glucose (sugar) levels, break down carbohydrates and fats, and is essential to produce the body’s energy. The CDC (2013) offers reliable insight, summarized here, into the different types of diabetes, some causes, and health complications that may arise from the disease.
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. American Diabetic Association. (2003). Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care, 26, 3160-3167. doi: 10.2337/diacare.26.11.3160
Diabetes mellitus type 2 is an endocrine disorder that causes impaired use of carbohydrates while enhancing the use of proteins and lipids. This is called insulin resistance, in which the pancreas cannot make enough insulin to keep blood glucose levels normal, or the body is unable to use what is produced. The impairment causes blood glucose level to rise higher than normal. There is no cure for type 2 diabetes mellitus and it is life threatening when left untreated. Signs and symptoms of this disorder include vision changes, increased thirst, increased hunger, increased frequency of urination, stomach pain, nausea and vomiting, erectile dysfunction, and absences of mentruation. These can occur abruptly, or over a long period of time. Long-term complications from diabetes include kidney damage, eye damage, and blindness. The risk factors for developing diabetes mellitus include genetics, sedentary lifestyle, high blood pressure, history of diabetes during pregnancy, poor diet, obesity, high cholesterol, and abdominal obesity. Diabetes mellitus can be managed through the use of medication, or by reducing risk factors, such as avoiding obesity, inactivity, and poor nutrition.
There are two types of diabetes. The type 1 and type 2 diabetes. Type 1 diabetes is referred to as dependent diabetes mellitus (IDDM), or juvenile onset diabetes mellitus. The pancreas undergo an autoimmune attack by the body itself, and is rendered incapable of making insulin. It is in type 1 diabetes where abnormal antibodies are normally found. Antibodies are proteins in...
Type 1 diabetes is controlled with insulin injections several times a day or the use of an
Glucose is a sugar that plays a big part in a human’s health and well-being. This sugar is a major source of energy for the body’s brain and cells. The Cells that receive energy from glucose help in the building of the body’s muscle and tissue. Although glucose may be important to the body too much of this sugar can cause a chronic condition called Diabetes. Diabetes, also known as Diabetes mellitus, is a chronic condition that is caused by too much sugar in the blood. This condition can affect all age groups. In fact, in 2010 a survey was taken by the National Diabetes Information Clearinghouse, on the number of newly diagnosed diabetes. Out of 1,907,000 people: 24.38% were ages 20-44, 55.17% were ages 45-64, and 20.45% were ages 65 and greater. Diabetes is a very serious condition, and it can be deadly if left untreated. This paper will help better educate the reader on the signs and symptoms, the testing process, and the management of diabetes.
Diabetes is a chronic disorder of metabolism characterized by a partial or complete deficiency of the hormone insulin. With this, there are metabolic adjustments that occur everywhere in the body. Specific to this child is Type One Diabetes. This is characterized by demolition of the pancreatic beta cells, which produce insulin. Because of this, it leads to complete insulin deficiency. Within Type One diabetes, there are two different forms. First there is immune-mediated deficiency, which typically results from an autoimmune destruction of the beta cells. The second type is called idiopathic type one, in which the cause is unknown. (Wong, Hockenberry, Wilson, 2015)
There are two main types of diabetes. The firsts is insulin-dependent diabetes mellitus (IDDM). In IDDM the body either doesn’t produce diabetes or produces very small amounts. The symptoms usually occur in teenagers under 20, usually around puberty. Untreated IDDM affects the metabolism of fat. Since the body can’t convert glucose into energy, it is broken down into fat and stored for energy. This also increases the amounts of ketone bodies in the blood, which interfere with respiration. The second type is called is non-insulin-dependent diabetes mellitus (NIDDM). This is when the body doesn’t make enough insulin or is unable to use it. NIDDM is the most common of all diabetes; it makes up 90 to 95 percent of all cases. Scientists believe that in some people weight gain or obesity is what triggers their diabetes because 80 percent of people with diabetes are over weight.
Diabetes Mellitus is a disease in which the pancreas produces little or no insulin. Insulin is a hormone that helps the body’s tissues absorb glucose which is sugar, so it can be used as a source of energy. Glucose levels build up in the blood and urine which causes excessive urination, thirst, hunger, and problems with fat and protein metabolism in a diabetic person. Diabetes is very common in the United States; it is the seventh leading cause of all deaths. Women have been diagnosed with diabetes more than men. There are two forms of diabetes, Type one and Type two diabetes. Type one diabetes is when the body does not produce insulin or produces it in very small quantities. This usually occurs in younger people under twenty years of age, mostly around puberty. Type two diabetes is when the body’s balance between insulin production and the ability of cells to use insulin doesn’t work properly. This is more common than type one; about 90-95% people in the United States have it. There are no cures for diabetes now but there are many researchers investigating factors through new technologies to cure them. Meanwhile, technological advancements are being made to keep glucose at a good level for diabetes.
Diabetes mellitus is a group of metabolic disorders which is characterized by hyperglycemia due to insulin deficiency or resistance or both reasons. (1) According to that diabetes mellitus can be divided as type I and type II. This is common and its incidence is rising, 171 million people had diabetes in 2000 it is expected this condition to be doubled in 2030. It is spread in all the countries and therefore has become a major burden upon healthcare facilities. (2)
In conclusion, diabetes is a serious disease and can be life threatening. With the right research and implementation of new studies diabetes can be reduced among the populations. We as a people need to realize this epidemic and all get together and beat it. Restaurants need to stop putting chemicals and unnecessary fats in their food. Not only diabetics but everyone should educate themselves on what is going in your body when you eat. Also, exercising and getting off the couch, in children, needs to be addressed and that alone would help reduce diabetes in the younger population. I can’t stress enough on education. If you know what you are eating or how you are exercising you protect yourself from poor health and live a great life. Type 2 diabetes can be dwindled down with a conscious individual and group effort.