Pesticide Essay

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The presence of pesticides in fruits, vegetables, cereals, in other food items and even in breast milk is a matter of grave concern (Munshi et al. 2001; FAO/WHO 2005; Damgaard et al. 2006; Koirala et al. 2007; Shen et al. 2008; Cok et al. 2011). There are many other studies which depict the presence of pesticide as residues in food materials above the established maximum residue limits (MRLs) (Bajpai et al. 2007; Devanathan et al. 2009; Srivastava et al. 2011). Out of 267 vegetable samples collected from the farmer’s field, 225 samples contained detectable residues representing 84% rate of contamination (Ahmed et al. 2007). In 1999, 4,700 samples of peppers, cauliflower, wheat grains and melons were analyzed (European commission 2001). Residues of methamidophos exceeded MRLs most often in all the vegetables (8.7%), followed by the maneb group (1.1%), thiabendazole (0.57%), acephate (0.41%) and the benomyl group (0.35%). In Brazil more than 90% of composite milk samples contained residues of organochlorine pesticides. Out of 100 composite samples, 44% of the samples contained aldrin followed by DDT (36%), mirex (34%), endosulfan (32%), chlordane (17%), dicofol (14%), heptachlor (11%) and dieldrin (11%) (Avancini et al. 2012). About 20% of Indian food products were found to be contaminated with pesticide residues above tolerance level compared to only 2% globally (TERI 2000).

Toxicity of Pesticides
Entry of pesticides through contaminated food or any other mode into the human body have been directly associated with health odds. Although pesticides were formulated to kill target pests, they had been toxic to non-target species as well and human beings not an exception. Many accidents have been reported in different parts of the wor...

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...cide. In this mode of action, pesticides structurally similar to the cognate ligand bind with the active NR causing conformational changes leading to release of inappropriate signals (Ruegg et al. 2009).
Indirect mechanism of endocrine disruption may be through inhibition of steroidogenic enzymes and binding to steroid transport proteins (Tebourbi et al. 2011). In this mode of action, pesticides compete for common cofactors and indirectly disrupt nuclear NR activity. Other possible mechanisms of indirect endocrine disruption include xenosensor induced ubiquitination of the receptor followed by targeted degradation of NR in proteosome; transcription of enzymes involved in hormone metabolism induced by xenosensors; blocking gene regulation through the nuclear receptor elements by binding of xenohormones to inhibitory xenobiotic response elements (Ruegg et al. 2009).

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