Alzheimer’s disease (AD) is a permanent condition that affects the brain. This condition progressively alters the working of nerve cells and ultimately leads to the death of brain cells. As a result, affected individuals lose the ability to remember even the most important details about themselves and their families. Alzheimer’s disease commonly occurs in individuals aged 65 years and above. Although most of the symptoms of this condition resemble those of the normal aging process, it is not related to natural aging at all and found to be the leading cause of dementia; the loss of logical capabilities. Complications with thinking, recollection, reckoning, and other essential functions can cause day-to-day activities to be more difficult.
Alzheimer’s disease is described as a progressive brain disorder that gradually destroys a person’s memory and clarity to learn, reason, make judgments, communicate, and carry out daily life. (r.1) Alzheimer’s is a disturbing disease affecting millions of elderly people. A person’s risk for the disease is fifty-percent when they reach the age of eighty-five.(r.1) Scientists have been studying the disease for many years now in hope to find answers to a cure for this depressive disease. The disease is persistently being studied with the hope of cures, and a better understanding of how one person can conquer Alzheimer’s disease.
Alzheimer’s disease No one realizes that it’s happening. No one believes it will happen to them, they’re too strong, too intelligent. First they forget where they put their car keys or glasses. Next, they forget the names of coworkers or family members and struggle to describe unseen objects.
Alzheimer’s disease (AD) is a degenerative brain disease that involves dysfunctions and loss of nerve cells in central nervous system, was discovered by a German physician, Dr. Alois Alzheimer in 1907. As it is accounted for 50 to 75% of all cases of dementia, it is the most common form of dementia (Blennow et al., 2006) and it is known as a progressive neuropsychiatric disorder which involves memory loss, mood swing and loss of intellectual and social skills (Lee et al., 2010) and sufferer will progress through seven-stages of Alzheimer but with different rate (Reisberg et al., 2003).
Over the last few decades, Alzheimer's disease has come to be recognized as the most common form of dementia among the world's older population, affecting an estimated 4 million people in the United States alone (1, 2). It is characterized by progressive loss of memory, language and reasoning skills, and other cognitive functions, as well as changes in personality, such as increased aggressiveness (1, 2). No definite cause has been discovered, and it is as yet without a cure; however, much progress has been and continues to be made, and many scientists believe that a cure will eventually be developed.
I choose to do my topic paper on a subject that is very emotional for me. Which is Alzheimer's disease. I choose this topic because being raised by my grandparents the majority of my life. I developed a close relationship with my grandfather. He and my grandmother adopted my brother and I, and I guess you could say that we had, and still have a close father-daughter bond. I did everything with my grandfather and in my eyes he was the ultimate hero. Growing up, as I got older and as he started aging more he seemed a little different. He was kind of off his balance with processing things in his mind and it bothered me because I didn't know what was going on. About a year before I entered junior high the local news was plastered with people being diagnosed with Alzheimer's. I prayed that wasn't the case with my grandpa. One morning I went to school and my teacher made us learn about Alzheimer's disease, she discussed what it is what it does and that there wasn't a way to prevent it, but researchers were trying to find a way out how. Immediately I was worried for my grandfather and really hoped that he didn't have it. Later that same day after school let out, my grandparents sat me and my younger brother down and told us that my grandfather had Alzheimer's disease.
One of the most fascinating neurocognitive disorders is Alzheimer’s Disease (AD). The neurocognitive disorder due to Alzheimer’s disease “is the reduction or impairment of intellect, emotion, and behavioral functioning severe enough to be detrimental in social, occupational, and other important areas in life” (Gray, 2016, pg. 459). The disease has a colossal impact on the individual’s life. A 2015 report concluded that approximately 5.3 million Americans are diagnosed with AD (Alzheimer’s, 2015). Some common symptoms of AD include deterioration of memory, awareness, thought process, and perception. AD affects various portions of the brain that causes cognitive impairment. AD is found to be more common among women and involves all ethnic groups (Gray, 2015). There is no cure for AD, but with appropriate medication and management strategies may temporarily improve symptoms.
Alzheimer’s is a disease that affects the nervous system and structure of the brain. It causes major cognitive and behavior impairment. According to Gene Alexander (2014), Alzheimer’s is the most common form of dementia. “Dementia occurs in a number of brain diseases where the impairment in cognitive abilities represents a decline from prior levels of function and interferes with the ability to perform routine daily activities” (Alexander 2014). People who are diagnosed with Alzheimer’s disease loose a lot of their memory. They have trouble remembering past events and learning new information (Alexander 2014). As aforementioned, it affects cognitive abilities such as language. As the disease gets worst, language starts to become a problem.
Presenilin Mediated Disruption of Intracellular Calcium Homeostasis in the Pathogenesis of Familial Alzheimer’s Disease. Introduction Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive cognitive decline resulting in memory and language deficits, personality changes, and gradual loss of independence. AD is the most common form of age related dementia, effecting over 5.2 million Americans age 65 years and older[1, 2]. Most cases of AD are idiopathic in nature, however a rare variant, Familial Alzheimer’s Disease (FAD), is related to autosomal dominant mutations in one of three genes: amyloid precursor protein (APP), Presenilin-1 (PS1) or Presenilin-2 (PS2).