Introduction to Synthesis of Acetylferrocene Introduction: Friedel-Crafts Acylation is a chemical reaction, and it is a type of electrophilic aromatic substitution. Electrophilic Aromatic Substitution is a type of reaction that uses electrophile for aromatic ring from their substitution of one group of atoms. In other words, they can transfer acyl group to an aromatic ring. Friedel-Crafts has an acyl group that is attached to the structure that has aromatic ring. Acylation is used to give ketones. Carbonyl group makes electron to move back or move away in Friedel-Crafts Acylation, so it has not produced multiple acylations. Moreover, Lewis acid and acid anhydride are usually used in Friedel-Crafts Acylation. For example, the Friedel-Crafts Acylation of Benzene has a mechanism that the acyl halide reacts with the lewis acid, and …show more content…
Furthermore, when phosphoric acid was added during the experimental process, the solution was turned into bright orange. The purpose for pouring the reaction mixture into sodium acetate solution is to raise the PH value and precipitate the product. In addition water and sodium bicarbonate solution is used in this reaction in order to remove the remaining acid from the organic layer. The organic layer also must be dried over anhydrous magnesium sulfate. The product was looked like red-brown solid when evaporator was used in order to remove the solvent. The percent yield was 26%, and the melting point of the product was 170c-172c. According to these results, it can be considered that there are a high range of reactant in the product because the melting point for Ferrocene is 172 and for Acetylferrocene is about 81-83. It is also showed that the product is not pure, and also the TLC was run. Table of wavenumbers and Functional Groups Wavenumbers Functional
The goal of this two week lab was to examine the stereochemistry of the oxidation-reduction interconversion of 4-tert-butylcyclohexanol and 4-tert-butylcyclohexanone. The purpose of first week was to explore the oxidation of an alcohol to a ketone and see how the reduction of the ketone will affect the stereoselectivity. The purpose of first week is to oxidize the alcohol, 4-tert-butylcyclohexanol, to ketone just so that it can be reduced back into the alcohol to see how OH will react. The purpose of second week was to reduce 4-tert-butylcyclohexanol from first week and determine the effect of the product's diastereoselectivity by performing reduction procedures using sodium borohydride The chemicals for this lab are sodium hypochlorite, 4-tert-butylcyclohexanone
This week’s lab was the third and final step in a multi-step synthesis reaction. The starting material of this week was benzil and 1,3- diphenylacetone was added along with a strong base, KOH, to form the product tetraphenylcyclopentadienone. The product was confirmed to be tetraphenylcyclopentadienone based of the color of the product, the IR spectrum, and the mechanism of the reaction. The product of the reaction was a dark purple/black color, which corresponds to literature colors of tetraphenylcyclopentadienone. The tetraphenylcyclopentadienone product was a deep purple/black because of its absorption of all light wavelengths. The conjugated aromatic rings in the product create a delocalized pi electron system and the electrons are excited
The goal of this lab is to exemplify a standard method for making alkyne groups in two main steps: adding bromine to alkene groups, and followed by heating the product with a strong base to eliminate H and Br from C. Then, in order to purify the product obtained, recrystallization method is used with ethanol and water. Lastly, the melting point and IR spectrum are used to determine the purity of diphenylacetylene.
The weight of the final product was 0.979 grams. A nucleophile is an atom or molecule that wants to donate a pair of electrons. An electrophile is an atom or molecule that wants to accept a pair of electrons. In this reaction, the carboxylic acid (m-Toluic acid), is converted into an acyl chlorosulfite intermediate. The chlorosulfite intermediate reacts with a HCL. This yields an acid chloride (m-Toluyl chloride). Then diethylamine reacts with the acid chloride and this yields N,N-Diethyl-m-Toluamide.
To treat the discarded reaction mixtures, another test tube was taken, and synthesized aspirin was added to it. Then it was clamped and placed under a gentle heat utilizing the Bunsen burner until the crystals were liquified. The odor of the vapor was noted from the test tube. Then 3 drops of phenolphthalein solution were added to the synthesized aspirin and the color was noted. If the solution was colorless 1M sodium hydroxide solution was added dropwise until the solution turned pink. If the solution was pink, then the 1M hydrochloric acid solution was added dropwise until the solution turned colorless. Finally, the solutions were poured out and washed and dry the
The percentage yield gained was 70% from the Fischer Esterification reaction, which evaluates to be a good production of yield produced as the reaction is known to be reversible where conditions such as the concentration of the reactants, pressure and temperature could affect the extent of the reaction from performing. These white crystalline crystals were tested for impurity by conducting a melting point analysis and taking spectrospic data such as the IR spectra, HNMR and CNMR to confirm the identification of the product. These spectrospic methods and melting point analysis confirmed the white crystalline crystals were benzocaine.
The theoretical yield of the m-nitrobenzoate was de-termined to be 4.59 grams. The actual amount of crude product was determined to be 3.11 grams. The percent yield of the crude product was determined to be 67.75 %. The actual amount of pure product formed was found to be 4.38 grams. The percent yield of the pure product was determined to be 95.42%. Regarding the thin layer chromatography, the line from the solvent front was 8 centimeters.
The isomerization procedure was done in order to create dimethyl fumarate from dimethyl maleate. Dimethyl maleate and dimethyl fumarate are cis and trans isomers, respectively. This procedure was done via a free radical mechanism using bromine. The analysis of carvones reaction was done in order to identify the smell and optical rotation of the carvone samples that were provided. The odor was determined by smelling the compound and the optical rotation was determined using a polarimeter.
Aspirin (acetylsalicylic acid) is a type of acid categorized as a salicylate, this acid works as a pain reliever in the body because once digested it lowers the amount of substances already in the body that cause pains, fevers and flare ups. Also, this chemical is administered to people for prevention of heart attacks, strokes, and angina which is also known as severe chest pains. Aspirin is created by chemically synthesizing salicylic acid through the acetylation with acetic anhydride, synthesizing aspirin comprises of three steps, synthesis of it, isolation and purification of it, and testing the purity of the aspirin made. Synthesizing aspirin is done by reacting salicylic acid and acetic anhydride with a catalyst, in which phosphoric acid (H3PO4) is used. After the aspirin has been prepared (synthesized), it must be isolated and purified. Aspirin is insoluble in cold water, therefore it can be isolated by filtering the cold solution product of the reaction. In order to remove the unreacted salicylic acid, acetic anhydride, acetic acid product and phosphoric acid the solution must be purified, the acetic anhydride is decomposed simply through the use of adding water after the reaction has finished (C4H602 + H20 2C2H402). Acetic acid and phosphoric acid can be removed from the solution by soaking the aspirin in cold water since they are soluble in water. The final ending step of purifying the aspirin is through a process referred to as recrystallization. This is when the aspirin is placed in warm ethanol, the solution is cooled, and the aspirin crystallizes leaving the salicylic acid and other impurities inside the solution. Lastly testing the purity of the finished product is achieved mainly from a melting point test a common...
Saturated sodium chloride solution, also known as brine solution, is used to wash the distillate mixture. The distillate mixture is the phosphoric acid the co-distilled with the product. The brine solution also removes most of the water from the 4-methylcyclohexane layer. When six drops of 4-methylcyclohexene were added with two
L-Acetylcarnitine, also named as ALCAR, an acetylated form of L-carnitine, fosters the uptake of acetyl coenzyme A (CoA) into mitochondria during fatty acid oxidation, raises the production of acetylcholine, and triggers the synthesis of membrane phospholipid and protein. ALCAR has been explored for use as an acetylcholine mimic as well as in targeting cardiovascular pathologies. Acetyl CoA, as the primary substrate for the Krebs cycle in mitochondria, must be re-charged with an acetyl-group in order for the Krebs cycle to maintain working when it is de-acetylated.
BIOC 2200 – Experiment 1: Buffers and the effect on amino acids. Aiden Forsyth 1009696399 Wednesday PM Bench 13 Results Question A1 - What is a.. By the Henderson-Hasselbalch equation (Plumber, 2004). pH=pka+log([HA])/([A-]) n_([HA])=M*V=0.10 mol/L*0.050L=0.0050 mol n_[A-] =
I will not add a catalyst to my solution and I will not stir my solution. · I will use 25cm3 of hydrochloric acid. · I will use 1g of calcium carbonate.
The aromatic nitroso derivatives can be prepared by oxidation of aromatic methyl hydroxylamine and with tert-butyl hypochlorite. This type of reaction is so fast and carried out at very low temperature around – 78 oC with high dilution to prevent over oxidation. The reaction between nitroso derivatives with aniline leads to the azobenzenes with good yield. Instead of tert-butyl hypochlorite, many other oxidising agents used for the formation of nitroso derivatives like ferric chloride, Caro’s acid (H2SO5), sodium or potassium dichromate and sulphuric acid, acetic acid/H2O2, m-chloroperbenzoic acid, potassium permanganate, ferricchloride, diethyl azodicarboxylate, iodine/NaI/NaOAc, silver carbonate, (diacetoxyiodo)benzene, 2,3-dichloro-5,6- dicyanobenzoquinone (DDQ) and peroxyformic acid also. Oxone are efficient to form nitroso arenes, which condense with aniline to form azobenzene in good yield (Fig 3). The mechanism of Mills reaction involves the attachment of aniline on the nitroso derivatives in acid media that leads to
The hydroxyl group present on the salicylic acid is corrosive. As a result, salicylic acid cannot be easily ingested. This property is present in many other compounds that have free phenolic groups. Therefore, an acetyl group, is added to salicylic acid to create acetylsalicylic acid (ASA). So