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Pathology of deep vein thrombosis
Pathology of deep vein thrombosis
Deep vein thrombosis pathophysiology essay
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Deep vein thrombosis (DVT) will happen when a thrombus (blood clot) forms in the deep veins in your body. The most common place of occurrence is the legs but can occur in other areas of the body. DVT may cause leg pain and/or swelling, but can occur without any signs or symptoms. Other signs and symptoms include; shortness of breath, rapid pulse, sweating, sharp chest pain, coughing up blood, and fainting.(mayo clinic)
In the United States alone 600,000 new cases are diagnosed each year. It has been referred to as "Economy Class Syndrome" due to the occurrence on long flights. One in every 100 patients who develop DVT die from pulmonary embolism (PE). If PE can be diagnosed and treatment started the mortality rate can be reduced from 30% to less than 10%.
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Certain medical conditions that affect blood clotting, sitting for long periods of time, can also cause deep vein thrombosis, other risks include; pregnancy, after a C-section, obesity, smoking, heart failure, previous dvt or embolism, increasing age especially over 60, cancer, kidney problems, certain medications, or hormone replacements. Less common risks are catheter in arm vein, insertion of a pacemaker or a defibrillator , cancer near vein. Surgeries that cause risk include; hip, pelvis, knee, brain, spine and any trauma especially if the blood vessel becomes injured can increase an individuals risk of developing a clot. Any surgery that reduces blood
Although we haven't covered these systems in detail yet, which of the following systems would involve gas exchange of CO2 and O2?
Many factors can increase the risk of these clots, including prolonged bed rest (such as after surgery), sitting for long periods (such as on a plane), use of birth control pills or hormone replacement therapy, pregnancy, family history of DVT, inflammatory bowel disease, and certain genetic clotting disorders. Compression stockings are also sometimes used in people who have an acute DVT, to prevent a group of symptoms known as post-thrombotic syndrome that includes leg pain and
One of the characteristics of the common disorder, and perhaps the most worrisome for the patients affected, is decreased blood flow in the atria, which is associated with and allows thrombi to form. Embolism from the atria can cause cerebrovascular accidents, which can be devastating to the affected individuals and their families.
If this happens, their immune system will develop antibodies against factor VIII. These antibodies will inhibit the ability of the factor to work in the clotting process. The higher the antibody or inhibitor level, the more factor VIII replacement therapy it takes to overcome the inhibition and produce clotting. This can complicate the treatment of a bleed. The good news is that there are different types of therapies available to successfully treat most individuals who develop inhibitors.
Ofri, D (2000). Diagnosis and Treatment of Deep-Vein Thrombosis. Western Journal of Medicine; 173: 194-197.
Deep venous thrombosis(DVT) is the formation of a blood clot or thrombus in the large vein of the legs(Narani, 2010). The signs and symptoms of a lower limb DVT varies from asymptomatic to extensive ilio femoral thrombosis(Narani, 2010). The most common clinical manifestation can be sudden swelling of one limb accompanied with pain or tenderness,
Atherosclerosis is a disease that occurs when arteries become blocked, inflamed, or hardened. As a result of this, blood cannot easily pass through the artery, and blood pressure increases. Many people suffer from atherosclerosis as they age, but young people can be affected by atherosclerosis also. There are many preventative steps that can be taken to decrease the risk of atherosclerosis; however, if atherosclerosis does develop in the arteries, medications can be given to help the individual receive adequate blood flow to important tissues. Atherosclerosis is a very serious condition that requires medical attention and a change in life style because it is a precursor to many dangerous and potentially fatal diseases.
Cardiovascular disease has become an increasingly significant issue in many countries as it is the leading cause of death for the whole human population. According to World Health Organization, ischemic heart disease had caused about 7 million people to lose their life in 2011. One of the most common cardiovascular illnesses is myocardial infarction. It is defined as the death of cardiac myocytes due to complete blockage of a coronary artery. t-PA is a thrombolytic drug that used to treat myocardial infarction by dissolving the thrombus that causes the occlusion.
After a thorough examination, J.P. was diagnosed with a deep vein thrombosis (DVT). “DVT develops most often in the legs but can occur also in the upper arms…” (Ignatavicius & Workman, 2013). Due t...
Compartment syndrome is a condition that can lead to dangerous levels when pressure builds within the muscles, causing the lower leg to be painful. This syndrome develops when bleeding and edema begin within a compartment. The lower leg has four major muscle compartments: anterior, lateral, superior posterior, and deep posterior. Blood flow is disrupted that is going to the muscles and nerve cells and without steady blood supply carrying oxygen, these nerves and muscles can be permanently damaged. Compartment syndrome can either be classified as acute, which is a more severe medical emergency, and chronic, a non-medical emergency. A fracture, bruised muscle, reflowing blood after blocked circulation, crash injuries, and constricting bandages
Lowering pulmonary hypertension, bringing more oxygen to the lung tissues and ease the cyanosis are the primary treatment focus for patient with ES (Freeborn & Holloway, 2016). Treatments include medicine, oxygen, and phlebotomy. According to Baffa (2014), heart and lung transplant are the only available treatment for a severe ES once the condition develops. A child will be given with great caution medications such as calcium channel blockers, prostacyclin, and endothelin receptor antagonists to dilate blood vessels and lower pulmonary hypertension. The provider may also prescribe diuretics to decrease the blood volume in case heart failure develops. According to Stanford Children’s Health (2015), removing some blood (phlebotomy) twice a year could also be ordered by a provider to reduce the number of red blood cells when the symptoms are so severe, and the hematocrit is extremely high. According to El-Chami and Willis (2014), a child could get oxygen therapy while sleeping or resting, or
Oxygen was first admitted to the client with chest pain over 100 years ago (Metcalfe, 2011). Chest pain is a large bracket that can contain many different conditions, but for the purpose of this analysis it is focused manly upon a myocardial infarction. A myocardial infarction is mainly referred to as a heart attack, and occurs when one or more coronary arteries leading to the heart reduce or completely stop blood flow (Tuipulotu, 2013 ). Administering high concentrations of oxygen to patients with chest pain is now embedded in guidelines, protocols and care pathways, even with a lack of clear supporting evidence (Nicholson, 2004 ). High concentration of oxygen means that up to 60% is administered (Knott, 2012). More recent research has suggested that the use of oxygen in this scenario is unnecessary and can lead to unwanted side effects, especially in normoxic cardiac patients (Moradkham & Sinoway, 2010 ). The aim of this comparative analysis is to dismantle and understand both the benefits and risks of the commonly known practice of administration of oxygen to the client with chest pain. Through completing this analysis using recent and appropriate evidence a more improved practice can be given and understood.
A PE usually begins as a clot in a deep vein of the leg, which is called deep vein thrombosis. This clot can break and travel through the bloodstream to the lungs and block the artery. Blood clots can form in the deep veins of the legs if blood flow is restricted and slows down. This can occur when you don’t move around for long periods of time. Some examples that can cause this are some types of surgery, during a long trip in a car or airplane, and if you must stay in bed for an extended period of time. Under rare circumstances an air bubble, part of tumor, or other tissue travels to lungs and causes ...
Keep the patient NPO, and establish two IV access sites with a large bore catheters running one IV with NS at KVO and morphine sulfate for pain. Initial laboratory testing including a complete blood cell count (CBC), basic metabolic panel (BMP), cardiac enzymes (creatine kinase, creatine kinase-MB, and cardiac Troponin) and repeat in 90 min. Administer antiplatelet ASA 324mg PO (Sen, B., McNab, A., & Burdess, C., 2009, p. 18). Before administering nitroglycerin 0.4 mg SL (every 5 minutes up to three doses) reassess blood pressure if systolic <90 mmHg, patient has used cocaine in the last 24 hours, or taking PDE-5 inhibitors do not administer. Thrombolytic therapy should be implemented within 30 minutes from the patient’s arrival to the emergency department, and if they are a candidate for cardiac catheterization it should be done within 90 minutes from the patient being admitted to the hospital. Delay on either therapy option increases the risk of mortality (Kosowsky, Yiadom, Hermann, & Jagoda, 2009, p. 10).
The most serious and last type of external bleeding is arterial bleeding. As the bloods pumps at a faster rate it is less likely to clot, as a result this leads to a large amount of blood loss.