Advantages And Limitations Of Aging

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Aging is defined as a systemic limitations of human biology that is vulnerable to wear & tear, and diseases. Aging studies can be performed in two ways : cross sectional or longitudinal. A cross sectional study can allow a snapshot of entire life without taking the time. It usually comprises large samples. A limitation of these studies include cohort effects and secular trends. Cohort effect are the effects of being born at the same time, exposed to the same events in society, and influenced by the same demographic trends and thus, having similar experiences that make the group unique from other groups. Normally, there is no measure of true change and variability in this technique. Individual differences are confounded with age differences. …show more content…

Moreover, there are lesser chances of contamination by preclinical trials. One of its major limitation include 3M 's that resembles Mobility, Morbidity and Mortality. Morbidity can start with middle age people and can change the statistic of a ongoing trial. Mortality suggests a study cannot be done forever. Upward biased selection is another limitation, which can be biased on the basis of smarter, healthier, higher SES, less depressed. The likelihood of such people to come for 2nd or 3rd time for trial is less. A noise reduction reliable measurement should be available for accurate data capture. Data must be captured at multiple occasion, for instance sample of 100 people should atleast have data recorded at 50 occasions. Large samples in this techniques is a big disadvantage. An equipment change or an upgrade in hardware or software can pose a big problem for longevity …show more content…

A basic latent score can be stated as Δy[t]n/Δ[t], where (Δ[t]= 1 ) is a dependent variable in some substantive equation. We add group coefficient that are the constant α and proportion β. Since, we are adding two additive components the model is stated as a dual change score (DCS) model. A regional longitudinal Brain Changes study in healthy aging indicates that the there is an immense change in volume for the lateral prefrontal cortex for ages 20 years to 80 years. The volume is constant for both the inferior parietal cortex and the primary visual cortex. A study on Brain shrinkage shows accelerated shrinkage in the caudate nucleus. A pericalcarine cortex and orbital frontal cortex exhibits stable shrinkage, while an entorhinal cortex depicts linear shrinkage (Raz, Lindenberger et al. 2005). Another two years study manifested significant shrinkage in Cerebellum, Orbital Frontal Cortex. A no mean shrinkage was observed in LPFC, Prefrontal Cortex, White, Putamen, Caudate Nucleus, Primary Visual Cortex. A dynamic equilibrium of structural changes in the brain can lead to angiogenesis, which is a development of new blood vessels. It can also cause axon expansion. Neurogenesis which is a phenomena that generates neuron form neural stem cells and progenitor cells can also be observed during structural changes in the brain. Structural changes

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