accept ADHD as a real disorder. It is known to be the most common disorder in adolescent children and teenagers. Attention deficit/hyperactivity disorder, commonly known as ADHD, is a real disease linked to changes in production of the brain chemical dopamine. 6.4 million kids ages four to seventeen have been diagnosed with ADHD since 2011. Inattention, hyperactivity, and impulsivity are signs and symptoms that the diagnosis is based off of. This disease has three subtypes. The subtypes include predominantly
One of the goals of personality psychology is to develop general understanding of each specific trait and the way they interact with each other to create such a variety of personalities. One of the traits that have attracted a considerable amount of attention is impulsivity. Impulsivity is viewed as acting in a spontaneous way, or not giving much thought to potential consequences of actions before they are carried out. Typically viewed in a negative light, Charles Carver and a few other personality
producing an inhibitory effect, at a variety of neurotransmitter receptors in the brain. The exact site and action by which Clozapine produces its therapeutic effects is difficult to locate due to the complexity of its interactions with several neurotransmitters. It is believed that the two key neurotransmitters that Clozapine interacts with are serotonin (5-HT) and dopamine (DA), particularly at 5-HT2, D2, and D4 receptors (Brenner, H.D., BÖker, W., Genner, R., 2001). Serotonin is a biogenic
Attention-deficit/hyperactivity disorder (ADHD) is the most frequently diagnosed neurobehavioral disorder in children and young adults (Schilling, Walsh & Yun, 2011). Though there is a breadth of research on the topic, the fact that individuals with ADHD have to overcome many difficulties throughout their life, like failing to inhibit inappropriate actions that can otherwise lead to antisocial behavior, severe injuries and in many cases end with imprisonment with 40-70% of detainees being diagnosed
ways in the brain. The most recent studies explore the cooperative effects of adenosine and dopamine, as well as the increase in calcium in the interstitial fluid and possible accumulation of cyclic adenosine monophospate. The most popular discussions of earlier studies of caffeine demonstrate its antagonistic effects on adenosine receptors. While it has been reported that adenosine receptors are located throughout the brain, the various subtypes can be found in very specific areas. Studies
hallucinogens) stimulate 5-HT2A receptors (Kalat, 2004). Activation of these receptors causes cortical glutamate levels to increase. This is presumed to be a result of a "presynaptic receptor-mediated release" from neurons in the thalumus (Nichols, 2004). Early studies proposed that LSD antagonized the effects of serotonin on peripheral tissues. It was later proposed that the psychoactive properties of LSD may be a result of the blocking of serotonin receptors in the central nervous system
The Dopamine Hypothesis of Schizophrenia Schizophrenia is a disease that has plagued societies around the world for centuries, although it was not given its formal name until 1911. It is characterized by the presence of positive and negative symptoms. Positive symptoms are so named because of the presence of altered behaviors, such as delusions, hallucinations (usually auditory), extreme emotions, excited motor activity, and incoherent thoughts and speech. (1,2) In contrast, negative symptoms
Clozapine is an atypical medication because it differs from the older conventional drugs such as Halodol or Lithium. The difference between atypical and the older drugs is because there less neuroleptic activity as a result of more specific receptors utilized. The atypical drugs work effectively to treat psychotic illnesses and tend to have fewer side effects than their predecessors. Clozapine has been found to be the most effective antipsychotic drug for treatment resistant schizophrenia
Dopamine is one of the most influential neurotransmitters in the human body. It plays a multitude of necessary roles in everyday life tasks such as regulating eating, sleeping, and even motor control. However, Dopamine has its dangers as well. In addition to being a major driving force behind addiction, imbalanced dopamine levels are a cause of a plethora of diseases including depression, ADHD, and Schizophrenia. With many of these conditions on the rise, it is clear at least that Dopamine is very
cognition. Dopamine The dopamine hypothesis of schizophrenia (Steeds et al., 2014, Peleg-Raibstein et al. 2008) attributes
become less wrong in the understanding of schizophrenia. Sources Cited 1)"An Introduction to Schizophrenia", http://www.schizophrenia.com/family/schizintro.html 2)"Ask the Experts", http://www.sciam.com/missing.cfm 3)"The Role of Dopamine Receptors in Schizophrenia", http://wwwchem.csustan.edu/chem4400/sjbr/mann.htm 4)"Schizophrenia", http://faculty.washington.edu/chudler/schiz.html
Addictive substances cause an increase a neurotransmitter called dopamine, which goes to a part of the brain called the nucleus accumbens and produces pleasurable sensations/responces. This pathway is called the reward pathway. Naturally dopamine release does not occur often, so when one repeatedly uses drugs that cause dopamine release receptor cells become overwhelmed and shut down. The brains ability to produce dopamine by itself decreases, but the need for it remains, creating a dependency
glutamatergic pathways, majorly at the level of NMDA receptors (Wen-Jun Gao). For more than 50 years, the dopamine hypothesis had been considered the mother of the theories of schizophrenia. Van Rossum first proposed it in 1966 suggesting that a hyperactivity occurring at the level of the mesolimbic dopamine pathway is the mediator of positive symptoms of schizophrenia (Seeman 1987). More research has flaunted a hypoactivity in the mesocortical dopamine pathway, which has been hypothesized to mediate
of the striatum depends on the type of receptor present on the post-synaptic cells. The cells of the striatum with D1
stimulus triggers the brain to release dopamine to give us pleasurable rewards when engage in behavior that people find pleasurable. Our ability to “feel good” involves brain neurotransmitters in this reward system. This reward system consists of dopamine-releasing neurons in areas of the brain called the ventral tegmental area (VTA), the nucleus accumbens, and the amygdala. The VTA dopamine system is strongly associated with the reward system of the brain. Dopamine is released in areas such as the nucleus
responsibility for regulating body chemistry known as the endocrine system and nervous system. The endocrine system depends on chemical messengers that flow in the bloodstream known as hormones. Hormones travel to target cells, where they connect with receptors that initiate chemical changes within cells. The nervous system depends on neurotransmitters that are electrical impulses in nerve cells activated by its own chemical messengers. The nervous system counts on a much faster means of circulation. This
Food addiction: A brief overview A current and major growing threat to the worldwide public health is the obesity epidemic. One proposal for certain types of obesity, such as those associated with binge eating disorder is that the individual suffers from a food addiction. A food addiction can be described as compulsive overeating by an individual and their lack of control of their food intake. The purpose of this paper is to describe the neurobiological bases of food addiction and how this relates
terminal. The neurotransmitter then crosses the synaptic gap to reach the receptor site of the post-synaptic neuron. Reuptake of the neurotransmitter is when it attaches to the receptor site and is reabsorbed by the neuron so it can be used again to pass along another action potential. They can be categorised as one of six types: acetylcholine, amino acids, neuropeptides such as endorphins, monoamines such as serotonin and dopamine, purines and lipids and gases (Cherry K, 2014). Psychoactive drugs are
euphoria resulting from an increase in dopamine activity (Barlow & Durand, 2012). Cocaine is effective in stimulating euphoria because of the dopamine agonists properties it possesses (Carlson, 2013). Mechanism: How does cocaine work? Action potentials in neurons are facilitated by neurotransmitters released from the terminal button of the presynaptic neuron into the synaptic gap where the neurotransmitter binds with receptor sites on the postsynaptic neuron. Dopamine (DA) is released into the synaptic
Journal of the Medical Association 272:1065-1066. Kaplan, G., D. J. Greenblatt, M.A.Kent, and M.M. Cotreau-Bibbo. 1996. Caffeine treatment and withdrawal in mice: Relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding. Journal of Pharmacology and Experimental Therapeutics 266:1563-1573. Phillis, John W. 1989. Caffeine and premenstrual syndrome. American Journal of Public Health. WWW1: Caffeine home page