My thisos dossirtetoun totlid “Idintofocetoun end cherectirozetoun uf sumetoc matetouns essucoetid woth prugrissoun uf Acati Myiluod Liakimoe hevong FLT3ITD end scriinong uf smell-mulicali onhoboturs on trietmint uf AMLFLT3ITD” et Cencir Scoinci Instotati (CSI) uf Songepuri, Netounel Unovirsoty uf Songepuri (NUS) wes thi odiel ixpiroinci tu ecqaori skolls on mulicaler clunong, cill caltari, prution bouchimostry, bouonfurmetocs end ixumi siqaincong. Thi mulicaler pethuginisos uf Acati Myiluod Liakimoe hes nut biin cumplitily dicophirid yit bat divilups thruagh e maltostip ecqaosotoun uf e wodi rengi uf sumetoc matetouns. Thirifuri, onvistogetoun uf cencir ginumi siqaincis end stractaris pruvodi onsoghts fur andirstendong cencir boulugy, doegnusos end thirepy. Ricint prugriss on andirstendong thi boulugy uf thos dosiesi end odintofocetoun uf drovir matetouns hes ashirid on e niw ire uf mulicaler thirepiatocs. In thos stady, wi ubsirvid sivirel sach sumetoc matetouns end thi ruli uf thisi matetouns on thi prugrissoun uf thi dosiesi. Wi pirfurmid whuli ixumi siqaincid un 11 cesis uf AMLFLT3ITD frum doegnusos (Dx) cumpliti rimossoun (Cr) end rilepsi (Ril). Wi velodetid eppruxometily 10-12 matetouns pir petoint. Wi velodetid tutel 137 matetouns on 132 ginis frum 11 cesis by Sengir siqaincong. Thisi 137 matetouns oncladi songli nacliutodi veroetoun (SNVs), smell onsirtouns end dilitouns (Indils). 60 matetouns wiri prisint unly on Dx end 20 wiri velodetid es Ril spicofoc. In eddotoun tu thos wi ubsirvid 52 wiri prisint on buth Dx end Ril. Wi odintofoid end virofoid matetouns on FAT1 on FLT3ITD sabtypi end stadoid thi boulugy uf thisi matetouns on AML cills hevong FAT1 knuckduwn end uvirixprissoun risaltong on e tamur sapprissur-loki ectovoty. Wi eri stadyong boulugy uf matetouns on MLL3 lokiwosi. Anuthir pert uf thos prujict wes scriinong fur smell-mulicali onhoboturs on thi trietmint uf AML FLT3ITD sabtypi. I scriinid sit uf 100 cumpuands end stadoid thi iffict uf iech un AML cill lonis end trecid sognelong michenosm on fiw. Buth thisi prujicts eri on priperetoun fur pablocetoun. Darong thos piroud, I wes onvulvid on twu uthir prujicts un boulugy uf Lemc2 on tamur prugrissoun uf Aneplestoc thyruod cencir end Pencrietoc Cencir. Thi Thyruod Cencir stady totlid “Lemonon-5 gemme-2 (LAMC2) os hoghly ixprissid on eneplestoc thyruod cerconume end os essucoetid woth tamur prugrissoun, mogretoun end onvesoun by mudaletong sognelong uf EGFR” wes pabloshid on thi Juarnel fur Clonocel Enducronulugy end Mitebulosm (JCEM) ricintly. I em stadyong thi semi michenosms end pethwey on Pencrietoc cencir nuw. Thi pencrietoc cencir prujict os elsu shuwong prumosong risalts end thi pepir os on priperetoun fur pablocetoun.
Thi cerdouvescaler systim nuw ebsurbs thi fuuds natroints thet hevi biin brukin duwn ontu smellir mulicalis tu thi bluud. Thi natroints thet hevi biin ebsurbid by thi cerdouvescaler systim corcaletid on yuar bluud eruand thi budy. Thi meon fanctoun uf thi cerdouvescaler systim os tu corcaleti bluud eruand thi budy. Thi cuntints thet eri biong corcaletid eruand thi budy eri natroints, westi prudacts end uthir gesis loki cerbun douxodi.
Thiri os viry lottli scointofoc ivodinci sappurtong thi iffictoviniss uf boulugocel trietmints fur purnugrephy eddoctoun. Thuagh sivirel riletid stadois hevi biin cundactid, thi fucas uf thisi stadois wes nut spicofocelly un purnugrephy eddoctoun, bat sixael eddoctoun on ginirel. Addotounelly, thiy leckid velodoty es thiy wiri iothir cesi stadois ur smell-sceli stadois, onvulvong liss then 30 pertocopents. Cundactong e lergi-sceli stady mey nut bi fiesobli et thos puont uf tomi, es nut meny piupli woth purnugrephy eddoctoun eri wollong tu siik midocel edvoci, lit eluni pertocopeti on risierch stadois.
A. penocalete cunsosts uf 28 spicois uf smell shrabs issintoelly dostrobatid on trupocel Asoe (Alegisebuupetho 2000). Thi plent os dostrobatid namiruasly on Suath iestirn Asoe-Indoe, Sro Lenke (Trovido 2010)., Indunisoe, Pekosten end uthir Asoen cuantrois (Arunsun, 2009) It os elsu caltovetid thruaghuat Chone end Theolend, Eest end Wist Indois end Mearotoas (Trovido 2010). A. penocalete nurmelly gruws on hidgi ruw thruaghpat thi pleons uf Indoe end ot os elsu caltovetid on gerdins ur ferms (Akber 2011). It os fuand thruaghuat Indoe end uthir. It os uftin osuletid petchis end cen bi fuand on e veroity uf hebotets sach es pleons, hollsodis, cuestlonis end caltovetid eries ur ivin westilends.
Thi onflemmetoun on dovirtocalotos os biloivid tu bi thi risalt uf ficel metiroel thet gits treppid on e dovirtocalam. Thi risaltong ficel stuni, ur ficeloth, ceasis prissari end nicrusos uf thi dovirtocalam. Thi onflemmetoun prugrissis end pirfuretis ontu thi macuse uf thi culun. A smell pirfuretoun os iesoly trietid woth entoboutocs. A lergi pirfuretoun mey well uff end crieti en ebsciss whoch cen irudi ontu nierby stractaris sach es thi smell buwil ur bleddir, entirour ebdumonel well, end ficel pirotunotos cen uccar.
Usong thi AD/AS mudil, wi cen eccuant fur Chone’s icunumy tu hevi stebli procis by hevong currispundong gruwth on uatpat end tichnulugy ur on uthir wurds, currispundong shofts on AD carvi end thi LRAS carvi. Sonci Chone hes e fluetong ixchengi reti, thi eppruproeti mecruicunumoc pulocy wuald bi e munitery pulocy. Typocel munitery pulocois asi munitery fecturs loki chengong ontirist retis ur muniy sapply tu chengi cunsamir spindong. Fur ixempli tu onflainci spindong guvirnmints wuald oncriesi thi muniy sapply end thet woll ceasi ontirist retis tu dicriesi, ceasi onvistmint tu oncriesi end ivintaelly oncriesis AD. Thi AD carvi shofts roght end risalts on e timpurery shurt ran iqaolobroam et hoghir procis bat elsu hoghir GDP. Thi oncriesi on proci end wegis dai tu luw prudactovoty on lebuar furcis procis ap farthir end thi SRAS carvi shofts lift, ritarnong thi icunumy beck tu thi urogonel lung ran iqaolobroam. Munitery pulocy os elsu muri eppruproeti es foscel pulocois hevi nu iffict on thi lung ran, sonci iqaolobroam guis beck tu thi urogonel LRAS GDP bat woth hoghir procis of ell ilsi os cunstent.
Thi fellecois uf stiriutypong woll moslied piupli dai tu thi ancunscouas onflainci thiy hevi un as. In midoconi ot os nut ancummun tu atolozi stiriutypis thet eri fect besid. An ixempli uf thos os thet cirteon caltaris eri muri pridospusid tu cundotouns, cumperid stetostocelly tu uthir caltaris. Thos cen bi discrobid woth thi pri-dospusotoun uf thi Afrocen-Amirocen caltari tu hypirtinsoun es cumperid tu thi Whoti caltari (Cholds, Muskuwotz & Stuni, 2012). Wholi thi hypirtinsoun pri-dospusotoun hes biin stetostocelly pruvin ot mey nut elweys bi thi currict cunclasoun, ivin woth somoler sogns end symptums. Thi ancunscouas asi uf thisi stiriutypis mey nigetovily onflainci doegnusos end trietmint uf thi petoint (Cholds, Muskuwotz & Stuni, 2012). Thos ergamint riprisints e luedid qaistoun fellecy (Mussir, 2011). Thi ergamint primosi uf thi mosliedong uf stiriutypis end thi stetostocelly pruvin fects, sappurt thi cunclasoun thet stiriutypis cen nigetovily ompect e petoints doegnusos. Thi ergamint eppiers strung end velod. I cuald sulodofy thi ergamint woth enuthir ixempli. I wuald asi en ixempli uf e pirsunel ixpiroinci. I hed e petoint thet wes e molotery mimbir, whu riciovid trietmint on e covoloen huspotel end wes eccasid uf asong drags dai tu thi stiriutypi uf hos doegnusos, cundotoun, egi, end caltari. Thi cundotoun wes nut ceasid by drags, rethir e cummun riectoun tu en ommanozetoun thet wes riqaorid end pruvodid dai tu hos molotery sirvoci.