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Vitamin D functions as a hormone to help maintain bone integrity
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Calcium and Vitamin D have long been the favored micronutrient supplements grouped together to battle osteoporosis despite the well-known roles that vitamin K plays in bone metabolism. The efficacy of supplementation of vitamin k to combat osteoporosis remains debatable due to the conflicting results of various studies. The potential benefits of vitamin k supplementation for aided bone formation and reducing fracture risk are especially important to postmenopausal women due to the fact that they are the largest group with osteoporosis. Since vitamin K is often a minor subject in the topic of preventative measure for osteoporosis, it is necessary to first delve into how exactly it is involved with bones on the molecular level. After focusing on vitamin K in the micro scale, research articles focusing directly on the potential positive effects of vitamin K supplementation in the postmenopausal target range will be analyzed. Following the discussion concentrating solely on vitamin K, the relationships between vitamin k and the other nutrients involved in bone health will be called into question. Regardless of the controversy and debates about supplementing vitamin K, it will be shown to be beneficial for fighting the onset of osteoporosis in postmenopausal women.
Vitamin K is a fat soluble vitamin that was believed at the time at the time of its discovery to only influence blood coagulation. Since then our knowledge on the vitamin, or group of vitamins, has drastically expanded. It is now known that vitamin K is an important cofactor in the activation of proteins belonging to the gla family (1. Vermeer C. ). Roughly 17 gla proteins have been discovered, among them being prothrombin, osteocalcin, and matrix gla-protein. Pro...
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...on and some research needs to be done to smooth out the edges but the potential for halting osteoporosis is still there. It can often be hard to tell if someone is vitamin K deficient after menopause especially since there is a decrees in osteocalcin carboxylation. The low amount could be from the diet, poor intestine absorption, or maybe even a need for a higher RDA for older populations. There are likely multiple reasons causing the osteoporosis is a person, so removing one of the problems with adequate vitamin K will surely help. There were two studies showing the benefits of Vitamin K1 and K2 as well as the usefulness of a vitamin K supplement in a group package so that it works to its fullest capacity. It has a long way to go but supplementation of Vitamin K1 and K2 have the definite possibility to halt the onset of osteoporosis in postmenopausal women.
Osteoporosis comes from the latin word meaning “porous bone”. If you were to look closely at a bone you could see there are these small spaces on the bone which is good, now if you look at someone who suffers from osteoporosis you will see these spaces are much larger. As these spaces become larger it takes away from the strength and integrity of the bone making it grow weak and thin. Osteoporosis is most common in women over the age of 50 and gives them a higher risk of fractures and or breaks especially common in the hips. While we know osteoporosis comes from a number of things it can be broken down to age, the hormonal changes most commonly seen in menopause and a lower intake of Vitamin D and Calcium. Age is the unpreventable factor that doctors or you cannot change. Hormonal changes can be fixed with supplements or hormone therapy along with ones intake of Vitamin D and Calcium. Hormone therapy, estrogen alone or the combination of estrogen and progestin have been proven to prevent and aide in the treatment of osteoporosis in
Her findings from this research was praised as she concluded that small supplementary feeding with fruits, milk and wheat germ improved the growth of school children. She also found out that the over dosage of Vitamin D produced brittle bones and calcification of soft tissues. If that wasn’t enough, she continued her extensive research and showed that pantothenic acid is essential for normal pigmentation of hair and skin. Lastly she was intelligent enough to prove that the bone density of woman decreased between 50 and 65 years of
Vitamin B12 deficiency limits selenium methylation and excretion resulting in higher tissue selenium levels and subsequent toxicity. It occurs in people whose digestive systems do not adequately absorb the vitamin from the foods they eat. Vegetarians who eat eggs and milk products are the most at risk because, on average, they consume less than half the adult vitamin B12 Recommended Dietary Allowance (RDA) while strict vegans (who don't eat any animal products, including meat, eggs, or milk) are at an even greater risk. Vitamin B12 is important since it works with the vitamin folate to make the body’s genetic material and help keep levels of the amino acid homocysteine in check which helps to decrease heart disease risk. It is also essential in the production of red blood cells which carry oxygen through the blood to the body’s tissues. Life Extension gives offers some of selenium supplements. Babies who are born of parents with low selenium and vitamin B12 rich foods are at risk of anaemia.
(13) Pazirandeh S. Overview of vitamin K. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed 27th April 2014)
UV exposure to skin can generate reactive oxygen species (ROS) that cause direct chemical alteration in collagen and increase matrix metalloproteinase (MMP) production leading to collagen break down. In addition, ROS produce mediators that cause skin inflammation. Vitamin C neutralizes ROS and is equally effective against UVA (320-400nm) and UVB (290-320 nm) that are produced due to UV exposure and causes skin-aging and sunburns respectively. Vitamin C is most effective as it exerts its action interacellularly and extracellularly (7).
Now, when considering one wants to prevent or treat Osteoporosis, it does not mean to cut yourself off of foods with small portions or extreme dieting. It is a common misconception that when a person wants to be healthy they must eat in smaller portions, and while this does have some truth, one must consider when it comes to eating healthy, it means to eat healthy by adding nutritious portions of fruits, vegetables, protein, carbs, and of course, calcium intake for the bones in one’s diet. Also, one must not deprive themselves of having a “cheat day” once a week with chips and candy. But it is a good start to begin adding calcium fortified foods and supplements, such as milk. People should at least aim for 1,000 to 1,200 milligrams a day of calcium. Low-fat cheese, milk, yogurt, orange juice, graham crackers, and calcium supplements are a beneficial contribution in accessing calcium to the body (Vander, 2003). Of course, Osteoporosis develops during old age, due to the gradual decline in exercising, calcium in bones, and weight loss. However, Osteoporosis is also genetically found in some people with a long history of family members who have had bone fractures. Also, many factors affect and can cause Osteoporosis and one of them is smoking. Because smokers have poor lungs, it can be difficult to exercise. Another is not going out too much,
Osteoporosis is associated with repeated fractures, tender bones, neck and back pain, a decrease in height as well as poor posture. There is a variety of factors that contribute to the development of osteoporosis. These include a calcium deficiency, possibly due to a poor diet, aging and old age, the loss of estrogen that comes with the onset of menopause in women, as well as genetics. There are several other diseases that contribute to osteoporosis such as Cushing’s Disease and rheumatoid arthritis. There are 40 million Americans who struggle with this disease, men as well as women although women are more likely to develop it due to the loss of estrogen during and post-menopause. The estrogen loss is a major factor in bone formation. Other factors include family members who have had the disease, smoking, and being on certain medications such as prednisone.
First of all, being a woman is one of the risk factors of osteoporosis especially after the age of menopause. “30% of American women between the ages of 60 and 70 have osteoporosis” (Marieb & Hoehn, 2016).To clarify, menopause is characterized by the loss of estrogen hormone production by the ovaries. Since estrogen is necessary for osteoblast to build new bone tissues, the lack of this hormone will improve the ability of osteoblast to absorb the bone tissues. Another risk factor of osteoporosis is being Caucasian. Caucasian women are more likely to get osteoporosis. 30% of Caucasian women experience a bone fracture in their lives that is related to osteoporosis” (Marieb & Hohen, 2016) . Furthermore, genetics are another risk factor of osteoporosis. Individuals with a family history of osteoporosis are at a primary risk for developing this condition. Moreover, a bad and unhealthy lifestyle including poor diet, lack of activities and exercise, smoking, and drinking too much are also risks factors of osteoporosis. In addition, low body weight is another risk factor of osteoporosis. Individuals with low body weight and small amount of fat and muscles are more likely to get this
Osteoporosis is a systemic, debilitating disease of the skeleton, characterized by significantly decreased bone mass in combination with the deterioration of bone microarchitecture. Osteoporosis has three types of categories the first category is type 1 which occurs in women after menopause and results from declining levels of estrogen and other sex hormones in the body, this could also occur in men due to low levels of the sex hormone testosterone. Type 2 is called Senile Osteoporosis, which occurs in elderly men as well as elderly women because of decreased bone formation due to aging. Type 3 is caused by long term use of medication usually with steroids and drugs to treat elipsy. Osteoporosis which literally means “Porous Bone”,
...tical in preventing osteoporosis and developing fractures. One of the most important ways to prevent this disease is already taking calcium and vitamin D for building and maintaining healthy bone. With these supplements and following a healthy diet plan can help you gain these and provide you with more helpful nutrients. In following your healthy meal plan, one should take into consideration the amount of alcohol they are drinking because it can damage your bones, a plan in action to quit smoking or stay away from smoking and to get into a routine of daily exercise for yourself. Exercise is one of best ways to improve your health including strengthening your bones, balance and coordination. It can prevent falls and may reduce your risk of fractures. The ability to get some sort of exercise during your daily activities can lessen your chances of getting osteoporosis.
Vitamin B12 is an essential nutrient that plays an important role in DNA synthesis and nerve function. It is contained in high amounts in animal derived foods such as milk, eggs, and meat. The vitamin is stored in the liver long-term. Individuals with vegetarian, vegan, or other forms of restricted diet may develop the condition after approximately 6 months as liver stores of vitamin B12 become depleted. Some individuals develop the condition due to autoimmune destruction of cells in the stomach that produce intrinsic factor. Intrinsic factor is necessary for proper absorption of vitamin B12 in the small intestine.
Women are at a higher threat of developing osteoporosis when their ovaries discontinue producing estrogen. This is due to the fact that estrogen supports maintaining proper calcium levels in bones. “A collapse of bony vertebrae of the spinal column results in loss of height and stooped posture. Hip fractures are a common occurrence.”
Vitamin E is the general classification for a group of eight fat-soluble compounds of tocopherols and tocotrienols. Vitamin E functions primarily as an antioxidant, but also has other roles in the body [1].
Vitamin D is a necessary component for calcium absorption to prevent boss loss. Nutritionally our body can create vitamin D by sun exposure however many factors can prevent our bodies to create vitamin D such as using sunblock or not getting enough sun exposer from daily routine. Vitamin D can be found in many foods that we such as milk including almond milk, eggs yolks, saltwater fish, and liver. Other vitamins that can help prevent bone loss are vitamin A and C. Vitamin C is an antioxidant which helps reduce oxidative stress which can have a negative effect on the cells in the body. This helps protect against inflammation which takes away calcium from the bones. Vitamin C can be found in many foods such as papaya, bell peppers, broccoli, Brussel sprouts, strawberries, pineapples, oranges and kiwifruit and fruit juices have supplement vitamins. Vitamin A is important for bone growth, vision, cell division and cell differentiation. There are two different forms of vitamin A are retinol and beta-carotene. Retinol can be found in meat, poultry, fish and dairy products while beta-carotene can be found in fruits, vegetables and
Investigation into the effect of storage or cooking on the vitamin C content of a food substance: