Sharks Disease

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Sharks are well known for their incredible resistance to disease. The exact reason for this resistance has always been a bit of a mystery. While performing research as a graduate student almost thirty years ago, John Marchalonis took several milliliters of blood from the heart of a shark. Marchalonis discovered two proteins, one large and one small, which could link together to form a Y-shaped structure. This Y-shaped structure, which consisted of the two proteins, had the ability to stick tightly to chemicals that did not belong inside the shark. This was an immune system response that would destroy the foreign invaders. This finding showed that sharks have disease-fighting antibodies that are similar to those found in humans.

Currently, …show more content…

Scientists have been unable to detect the presence of these proteins and antibodies in any group that evolved before sharks. This is one reason that sharks are being studied so heavily but, even with the presence of antibodies and other important proteins, sharks exhibit a rather sub-par immune system. There have been experiments in which sharks were injected with foreign proteins. The sharks did create antibodies to bind to the foreign proteins but the response did not improve upon repeated injections as it does in humans. Even with these findings, sharks are known to be very disease resistant. Contrary to popular belief, sharks do get cancer but it doesn’t happen easily. Scientists must somehow make sense of the shark’s rather substandard immune capacity. One possibility could be that sharks do not require the same immune system functions humans do in order to …show more content…

According to Mike Zasloff, President of Research of Magainin Pharmaceuticals, sharks rely less on TCRs and antibodies and more on squalamine. Squalamine, as well as other shark chemicals, are considered potent killers of many bacteria and also seem to ward of viral infections. Magainin Pharmaceuticals is trying to develop squalamine for commercial use in prescriptions like the health food stores which sell shark cartilage since the early 1990’s. Many companies and people have been quick to point out the benefits of shark cartilage even though most of the claims have not been proven by true scientific research. Unfortunately, sharks are being over fished worldwide because of the cartilage

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