Osteoarthritis Essay

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The most common musculoskeletal disorder and a major cause of disability in people over 65 years is osteoarthritis (OA) (Felson DT et al, 1987) (1). According to World Health Organization (WHO) report, OA of knee is more likely to become the fourth most important cause of disability in women, and the eighth most important cause in men (Murray CJL, Lopez AD, 1997)(2) . Primary prevention of knee OA has become a major health care aim and a clear understanding of the risk factors is required to design preventive strategies. Many investigations reported obesity, previous history of knee injury, sedentary life style, hand OA (Heberden’s nodes), and a familial history of the disease are major risk factors for OA of knee (Cyrus Cooper et al, 2000) (3). In spite of recent advancements the causes and pathogenesis of knee OA remains largely unknown (A Teichtahl, A Wluka, F M Cicuttini, 2003) (4) but however there is increasing research interest in the contribution of biomechanical variables on progression and management of the disease (Andriacchi TP, 1991) (5).
Obesity is a global problem (Tremolieres 1973; WHO 2000) (6). It increases numerous health risks including coronary heart disease, hypertension, stroke (WHO 2000) (7) and is a major risk factor for musculoskeletal pain (Nantel, Mathieu and Prince, 2011) (8) and osteoarthritis of weight bearing joints (WHO 2000; Felson et al, 2000) (9). Obesity rates are growing high every year and in the last 15 years twofold increase is recorded (10). Obesity is categorised on body mass index (BMI). Body mass index is used to measure obesity and is calculated by dividing a person’s weight (in kilograms) by the square of their height (in metres). Overweight is taken as BMI of 25 to 29.9kg/m2 and BMI...

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...ase, has not been explored so far. The purpose of my research is to explore whether these responses are compromised prior to occurrence of osteoarthritis because of increased joint loading and poor neuromuscular responses. Despite recent advancements in characterising gait in obese adults, the current literature is lacking in comprehensive biomechanical studies that consider simultaneous neuromuscular responses (such as proprioception, quadriceps strength, range of motion) in lower limb joints that may contribute and initiate OA.
In this regard I hypothesise that altered biomechanics combined with poor neuromuscular responses in obese adult may have an association with OA. To the best of my knowledge there are no other studies that compared the knee biomechanics along with respective neuromuscular responses within non obese, obese and OA effected adult groups.

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