Modafinil is a wake-promoting drug that has been prescribed for conditions such as sleep disorders, stimulant dependence, and attention deficit disorder [6]. The U.S. Food and Drug Administration classifies modafinil as a Schedule IV drug [2]. The official website for Drug Enforcement Agency states that Schedule IV drugs have low potential for abuse and minimal risk for dependency [5]. However, off-label use of modafinil is becoming widespread. The drug has received some media scrutiny due to its unique effects. Athlete, cultural members of Wall Street, and others exposed to long-hour and stress-filled environments have taken non-therapeutic advantage of the drug. In fact, modafinil is banned by the World Anti-Doping Agency, who compares the stimulant effect of the drug similar to amphetamine. Increasing popularity of its use has many questioning the drug’s true addiction potential [2]. And, if modafinil has low addictive properties, how does its elusive mechanism play a role in abuse?
Modafinil has a profound mechanism of action that still remains deceptive to pharmacologists today. Starting from the early 1990s, the mechanism for modafinil has been extensively researched on its effects on the brain [6]. Beyond the stimulant effects of the drug, research data suggests that modafinil may enhance cognitive function including creative problem-solving, spatial memory, decision making, and motivation [12,19]. Currently, various neurochemicals including catecholamines, GABA, histamine, glutamate, and hypocretin have been reported to be involved in producing the novel effects of the drug [21]. Evidence suggests that the catecholamines dopamine and glutamate participate in the mechanisms of abused substances. Both neurotr...
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...e modafinil’s increasing widespread use among populations exploiting its effects as a stimulant and a performance enhancer. The neurotransmitters dopamine and glutamate seem to participate in its mechanism of action and have also been shown to engage in pathways of addiction. Through DAT inhibition, the above research states that modafinil may increase dopamine levels in the brain’s reward center, which suggests the possibility of addictive behavior. Glutamate also seems to play a role in addiction. However, the action of glutamate in modafinil pharmacology is unclear. Previously stated evidence makes one speculate that the presence of extracellular glutamate in the brain supports the potential for addiction. Unfortunately, modafinil’s mechanism of action remains elusive. For now, popular research overpowers the argument against its large-scale abuse.
Introduction: For my research project I would like to explore the effectiveness of antidepressant drugs. Antidepressant drugs are used are used to treat major depression and other conditions, some of which include anxiety, obsessive compulsive disorder, chronic pain and other disorders. Around the world antidepressants are used to cure these types of mental illnesses. It is argued by both medical professionals and other people whether or not they believe that antidepressants work. According to Mayo Clinic one in ten Americans take an antidepressant. Today, antidepressants have became the most common way around the world to treat major depression
The need for Ritalin and other CNS stimulants arises from a decreased amount of dopamine—a hormone closely linked to the motivational process((3)). A deficiency of this hormone can lead to difficulty in focusing and agitated behavior, among other traits1 ((1)). Methylphenidate, serving as a stimulant, augments the release of this hormone. The resulting state is similar to that after caffeine, on a milder scale, or amphetamines1 ((1)). This attribute can lead to the somewhat addictive nature of the drug.
In summary, Laurence’s article sanctioning ketamine as a cure for depression is an interesting and well-written article, however, it could give people the wrong idea about ketamine. There is a rapidly increasing interest in the discovery of drugs targeting glutamate neurotransmitter in the brain, as a hope to rapidly treat treatment-resistant patients (Duman & Ronald, 2013). While the mentioned studies in the article and this essay have given insight into ketamine’s antidepressant effects, this is still something that needs to be researched further as a lot of unresolved problems are still around with ketamine. Furthermore, the potential side effects of ketamine, including bladder and kidney damage, hepatotoxicity and psychological effects still require extreme consideration.
Since Bipolar Disorder involves the cycling between two different states of mania and major depression, there are many different etiological factors in play. The neurotransmitters that are involved in this disease are serotonin, norepinehrine and dopamine. There has been some preliminary research involved with glutamate as well. In patients with the depressive portion of Bipolar Disorder, Serotonin levels were found to be lower than healthy, non-depressed patients (Young, Warsh, Kish, Shannak & Hornykeiwicz, 1994). Young et. al. (1994) found reduced amounts serotonin’s metabolite, 5-HIAA, in frontal and parietal lobes of deceased bipolar disorder patients. Norepinehphrine was also found to be lower as well. During the depressed state of bipolar disorder, the concentration of norepinehphrine ‘s synthesis enzyme, tyrosine hydroxylase, was lower in the locus coeruleus than patients who only had depression and not Bipolar Disorder (Wiste, Arango, Ellis, Mann, & Underwood, 2008). Although in the mania cycle of Bipolar Disorder, Norepinephrine is found to be elevated in the brain (Manji & Lenox,2000). Furthermore, Dopamine was also found to be lower in the brain as well during the depressed state of Bipolar disorder. According to a study by Vawter, Freed, Kleinman (2000), the concentration of the metabolite of dopamine, homovanillic acid, was found to be significantly lower in the parietal lobe of the brain. Dopamine Agonists, while they can treat the depression cycle of the disorder, can also bring about the mania in the disorder; therefore, the pharmacological treatment of the Bipolar disorder must be regulated heavily so that the treatment itself doesn’t exacerbate the disorder instead of treat the disorder (Manji et. al. 2003). ...
Credibility material: Its intake results in adverse medical conditions that are further exalted by its addiction properties that ensure a continued intake of the substance. The drug can be abused through multiple means and is medically recorded to produce short-term joy, energy , and other effects such as increased heart rate and blood pressure. This ultimately results in numerous psychiatric and social problems; factors that played a major role in its illegalization after multiple and widespread cases of its effects were reported in the country during the 1900s. In addition to this, the drug results in immediate euphoric effect, a property which the National Institute of Drug Abuse (2010) attributes to be the root cause for its increased po...
Koob, G. F., & Simon, E. J. (2009). The Neurobiology of Addiction: Where We Have Been and Where We Are Going. NCBI, 115-132. Retrieved APRIL 26, 2014, from www.ncbi.nih.nlm.go/pmc/articles/PMC2901107
Brecher, Edward M. (1972) Licit and Illicit Drugs; The Consumers Union Report on narcotics, stimulants, depressants, inhalants, Hallucinogens, and marijuana- including caffeine, nicotine, and alcohol. New York, 291-390
Another growing fad in the United States is the abuse of prescription drugs. The abuse is being done by not only adults but by teens. The most current trend today is the misuse of cough syrups and prescription medications to produce a “high.” Other medications abused today are stimulants (Ritalin), and benzodiazepines (Xanax). Health Watch (2004) state girls tend to lean towards the medi...
There are some key distinctions between Randomized Controlled Trials (RCT) in a psychotherapeutic context and a medical context. There are key differences between the design of an RCT to evaluate a new drug and an RCT to evaluate a new form of couples’ therapy. However, it is important to begin by defining and understanding the importance of RCT in research (O'Brien, 2013).
crashes.." Addiction 103.5 (2008): p749-757. Academic Search Premier. EBSCOhost. UMBC, Baltimore, Albin O. Kuhn Lib. 4 Mar 2011.
The altered states of consciousness produced by drugs presents an all-to-common phenomenon in today’s society. Whether the desired sensation comes in the form of energy, a means of relaxation, or pain reduction, many people go to great lengths and present their bodies to threatening conditions in order to achieve this euphoric “high.” Unfortunately, the use of these drugs very often comes with dangerous side effects that users must learn to manage with for the rest of their life. According to neuroscientists, our entire conscious existence bases itself off of the lighting-fast reactions occurring in our nervous system (Nichols, 2012). Therefore, changing these neurological reactions can permanently effect our conscious being (Blatter, 2012). The physical and neurological effects from the use and abuse of stimulants, sedatives, hallucinogens, organic solvents, and athletic performance enhancing drugs will be discussed in order to better comprehend why certain individuals expose themselves to such dangerous materials with seemingly no regard to the permanent consequences associated with such actions.
Humans are environmentally and genetically predisposed to developing a motivated addictive behavior. Addiction is a brain disease and a behavior. All behaviors are choices. Choices that adolescences make at a young age directly affect the outcomes of their futures. Many factors contribute to an adolescence becoming an addict or exhibiting a drug seeking behavior. Nearly all drugs of abuse increase dopamine release. Dopamine is an important neurotransmitter in drug abuse and addiction. Dopamine plays a role in reward motivated behaviors, motor control and important hormones. It’s known as the “feel good hormone” which is why people abuse drugs that increase the release of dopamine. Since life is unpredictable, our brains have evolved the ability to remodel themselves in response to our experiences. The more we practice an activity the more neurons developed in order to fine-tune that activity causing addictive behaviors to be detrimental.
Drug abuse has been a hot topic for our society due to how stimulants interfere with health, prosperity, and the lives of others in all nations. All drugs have the potential to be misapplied, whether obtained by prescription, over the counter, or illegally. Drug abuse is a despicable disease that affects many helpless people. Majority of those who are beset with this disease go untreated due to health insurance companies who neglect and discriminate this issue. As an outcome of missed opportunities of treatments, abusers become homeless, very ill, or even worst, death.
The use of drugs is a controversial topic in society today. In general, addicts show a direct link between taking drugs and suffering from their effects. People abuse drugs for a wide variety of reasons. In most cases, the use of drugs will serve a type of purpose or will give some kind of reward. These reasons for use will differ with different kinds of drugs. Various reasons for using the substance can be pain relief, depression, anxiety and weariness, acceptance into a peer group, religion, and much more. Although reasons for using may vary for each individual, it is known by all that consequences of the abuse do exist. It is only further down the line when the effects of using can be seen.