Jeremy Laurance’s article “Ketamine: a cure for depression?” published in The Independent in October 2012, sanctions the use of a drug of abuse called ketamine for the treatment of depression. The author supports this theory by stating a study completed by Robert Dunman, a professor of Psychiatry and Neurobiology at Yale University School of Medicine in Boston. The following paragraph will summarise the main points of the article and discuss the evidence used by the author.
At the beginning of the article a brief history of ketamine is given, describing its use as a anaesthetic during the Vietnam war in the 1960s, its use in veterinary medicine as a horse tranquiliser and its revolution as a drug of abuse in the dance scene in the 1990s. The article also mentions the side effects heavy users have experienced from using ketamine, mainly increased bladder and kidney damage. Furthermore, after a review by the Government’s Advisory Council on the Misuse of Drugs, concerns have increased about this side effect, as patients have become very unwell needing a total bladder removal. Laurance mentions Robert Dunman, who describes ketamine as the “biggest breakthrough in depression research”. Professor Duman studied the effects of ketamine, which are meant to be triggering the release of glutamate, increasing and restoring the function of neuron synapses, which are reduced in patients with chronic depression. The article states that ketamine has shown to be able to increase mood levels with a single dose and effects lasting up to 10 days. Due to this Laurance sanctions ketamine’s potential use as a treatment for depression, mentioning that a third of patients with depression are not improving from current treatments available for depressio...
... middle of paper ...
...ne’s safety and use could be further researched as a potential treatment for depression.
In summary, Laurence’s article sanctioning ketamine as a cure for depression is an interesting and well-written article, however, it could give people the wrong idea about ketamine. There is a rapidly increasing interest in the discovery of drugs targeting glutamate neurotransmitter in the brain, as a hope to rapidly treat treatment-resistant patients (Duman & Ronald, 2013). While the mentioned studies in the article and this essay have given insight into ketamine’s antidepressant effects, this is still something that needs to be researched further as a lot of unresolved problems are still around with ketamine. Furthermore, the potential side effects of ketamine, including bladder and kidney damage, hepatotoxicity and psychological effects still require extreme consideration.
This paper will have two sections: The first section will be a brief explanation on what is depression. In addition, what is the percentage of depress people in the United States. Furthermore, it will discuss in details several theories that are best suited to treat depression disorder. Moreover, the theories that will be briefly discussed are as follows: Cognitive Therapy (CT), Cognitive Behavioral Therapy (CBT), and Interpersonal Therapy (IPT). The second section will be a summary of a counseling session the learner had with a client and the treatment that was given to help alleviate and ceased the depression from reoccurring.
Introduction: For my research project I would like to explore the effectiveness of antidepressant drugs. Antidepressant drugs are used are used to treat major depression and other conditions, some of which include anxiety, obsessive compulsive disorder, chronic pain and other disorders. Around the world antidepressants are used to cure these types of mental illnesses. It is argued by both medical professionals and other people whether or not they believe that antidepressants work. According to Mayo Clinic one in ten Americans take an antidepressant. Today, antidepressants have became the most common way around the world to treat major depression
Treating depressive and bipolar disorders with antidepressants remains a popular option in clinical practice. Most clinicians choose the drug or class of drugs, usually selective serotonin reuptake inhibitors, SSRI's, that is most effective and best tolerated with fewer severe side effects. These drugs are beneficial because they specifically target serotonin-based areas of the brain without affecting other neurotransmitter systems. SSRI's largely replaced tricyclic antidepressants which work by blocking the absorption (reuptake) of the neurotransmitters serotonin and norepinephrine, thereby increasing the levels of these two neurotransmitters in the brain. Tricyclic antidepressants present severe side effects and thus are usually only used when other treatments have failed. If SSRI's or tricyclics are not effective Monoamine oxidase inhibitors may be prescribed. MAOI's, enhance tyramine to increase norepinephrine and serotonin. While taking MAOI's you must abstain from foods and alcohol that contain tyramine such as, yogurt, aged cheese, and substances such as cold medications. This is because a potential toxic reaction could occur. Additionally, other antidepressants may be utilized such as Wellbutrin (bupropion) an NDRI-
Antidepressants are FDA approved drugs given to patients to alleviate symptoms, most commonly anxiety and depression. There are many people who are skeptical about the use of these drugs and if they really work as a benefit toward the people taking them. There are many pros to taking the medications, but there are also cons. This is why users of these drugs have to be aware of the side effects in order to get the full use of the medicine. Research shows that the benefits of antidepressants outweigh the negative long term effects, but only if they are taken in moderation.
In Western society, depression is defined as a downcast mood or a loss of pleasure in previously interested activities. In Japan, however, depression is understood as a mental disorder and often a fatal state of sorrow. People in China describe depression as physical pain, while American Indians describe it as an overwhelming sense of loneliness. A prestigious writer who has published work in the New York Times Magazine, and Wired, among others, Ethan Watters wrote a great piece about the controversial issue of Depression and how it is viewed differently in his piece called The Mega-Marketing of Depression in Japan. His piece, in my interpretation, concluded that depression is perceived distinctly among different cultures based on the societal
Cropper, Carol Marie. “A Cloud Over Antidepressants” Businessweek 3880 (2004): 112-113 Business Source Premeir. Web. 28 Jan. 2014
Modafinil has a profound mechanism of action that still remains deceptive to pharmacologists today. Starting from the early 1990s, the mechanism for modafinil has been extensively researched on its effects on the brain [6]. Beyond the stimulant effects of the drug, research data suggests that modafinil may enhance cognitive function including creative problem-solving, spatial memory, decision making, and motivation [12,19]. Currently, various neurochemicals including catecholamines, GABA, histamine, glutamate, and hypocretin have been reported to be involved in producing the novel effects of the drug [21]. Evidence suggests that the catecholamines dopamine and glutamate participate in the mechanisms of abused substances. Both neurotr...
Antidepressants are a prescription drug now used by people of all ages. They have become a part of society, therefore, taking antidepressants is not frowned upon. Antidepressants are used to make people feel “happier” and not to feel sadness. This is shown in the dystopian society in the book Brave New World written by Aldous Huxley in 1932. In that society the people use soma, a well-known drug, to make them feel no pain and are conditioned to think soma fixes everything. Helmholtz and Bernard two main characters, do not take it because they want to be able to see the world for what it is. They also do not want soma to change how they feel; they want to appreciate nature. In addition Lenina and Henry love taking soma because then they cannot feel any pain, they are just happy all the time. In our society, people think that antidepressants will make them feel no pain and that these medications will fix all of their problems. Antidepressants have a negative impact on society today as well as in the book Brave New World.
Approximately 5% of the United States' population experiences a depressive episode that requires psychopharmacological treatment; in any one year, 10-12 million Americans are affected by depression, with the condition twice as common in females than in males. It has been estimated that 15% of patients hospitalized for depression will commit suicide. These figures are incredible, so finding the root of the problem when it comes to depression is extremely important. "Alterations in serotonin metabolism may be an important factor in the etiology and treatment of depression." (7).
Antidepressant are a form of pharmacotherapy treatment developed to treat the symptoms of major depression. Antidepressants are used for many other types of conditions including anxiety disorders, obsessive compulsive disorder, dysthymia, eating disorders, sleeping disorders, and substance abuse, pain syndromes, gastrointestional disorders. Antidepressants usually require several weeks to notice significant effects. There are no antidepressants or any medication that is completely free of adverse effects. This article explains that the adverse effects of antidepressant can decrease compliance and slow down the rate of recovery. It is important for one to take note of potential side-effects before choosing the best antidepressant to suit their personalized needs. Statistics show that about 28 percent of patients sto...
Through my extensive research on depression I have learned a lot of new things. I have learned about the many forms of depression and treatment for depression. I have also learned a little about what is believed to go on chemically in the brain of a clinically depressed person. I was also able to partially determine what sort of role genetics, chemicals and personal influences in the brain. Though I was unable to determine exactly how environmental and personal stress can cause a chemical imbalance in a person, I was even able to speculate about this issue and determine some theories of my own on why and how this may happen.
Kaut, K. P., & Dickinson, J.A. (2007). The mental health practitioner and psychopharmacology. Journal of Mental Health Counseling, 29(3), 204–225.
Growing up, Ken Kesey lived in Oregon with his family. When he grew older, he attended Stanford University in the 1960’s. While attending the college, he was offered a chance to partake in a government experiment and earn extra money. The medical experiment was on the use of hallucinogenic drugs and the effects that they had on the human mind. During the time of the experiment, Kesey took various mind-altering drugs such as LSD. The newly introduced drug allowed for Kesey to have unique experiences and perceive the world in a different manner (Vitale).
Depression is a mental illness, which affects millions of Americans each year. Currently there are many prescription drugs, called anti-depressants that have been proven to successfully treat it. The causes of depression are somewhat of a medical enigma, however, it is known that depression is associated with a change in the brains chemistry involving the function of neurotransmitters (Reichert). This chemical change occurs in healthy brain’s, which experience sadness, but ends after the unpleasant stimulus is removed. In people suffering from depression this chemical change does not correspond to any particular stimulus. Symptoms of depression are often incapacitating and include severe and extended sadness, feelings of worthlessness, feelings of emptiness, irritability and anxiety (Reichert, Spake).
Major depression, in itself, is a debilitating mental disorder that negatively impacts most or all aspects of a sufferer’s life and often times can even lead to suicide. Just to give a few numbers, at least 1 million people worldwide every year take their own life (Hawton and Heeringen 1372-81), half of which are caused by the possession and improper or unsuccessful treatment of major depression (Chehil and Kutcher 30-33). In light of these dark statistics, the benefits and limitations of the main treatments for major depression, antidepressants and psychotherapy, are not only worth investigation, but with thousands of lives on line, vital to the human race. However, to take it further, there is much to be said of human nature in general as it relates to how people respond to the biological treatment of antidepressants as opposed to the cognitive and sociocultural treatment of psychotherapy. Is it possible that the various symptoms of sadness and hopelessness characteristic of major depression can be cured simply by balancing the chemical messengers in charge of happiness and motivation in the brain or must the need to be perceived and understood through therapy be satisfied? Are we, as humans, simply biological machines, or is there something more?