Fibrous dysplasia is a genetic disorder and there's no cure. Treatment, which may include surgery, focuses on relieving signs and symptoms.Fibrous dysplasia may cause few or no signs and symptoms, particularly if the condition is mild. More severe fibrous dysplasia may cause: Bone pain, Bone deformities, Fractures, and Nerve entrapment. Severe fibrous dysplasia can cause: Bone deformity or fracture. The weakened area of an affected bone can cause the bone to bend. These weakened bones also are more likely to fracture.Vision and hearing loss. The nerves to your eyes and ears may be surrounded by affected bone. Severe deformity of facial bones can lead to loss of vision and hearing, but it's a rare complication.Arthritis. If leg and pelvic bones are deformed, arthritis may form in the joints of those bones.Cancer. Rarely, an affected area of bone can become cancerous. This rare complication usually only affects people who have had prior radiation therapy. …show more content…
This can relieve pain and help reduce the risk of fractures.Your doctor may recommend surgery in order to: Correct a deformity, Correct a difference in limb lengths, Fix a fracture remove an affected area of bone that's causing you difficulty Relieve pressure on a nerve, particularly if the lesion is in your skull or face. Surgery may involve removing the bone lesion and replacing it with bone grafted from another part of your body or from bone tissue donated from deceased donor. Your surgeon may insert metal plates, rods or screws to stabilize the bone and the graft. Risks include infection, blood clots and bleeding. In addition, a bone graft may not
Fibrodysplasia ossificans progressiva also known as FOP is a one of the rarest, most disabling genetic bone conditions known to medicine. FOP causes muscles, tendons, ligaments, and other connective tissues to turn in to bone. Movement becomes limited in the affected areas of the body. People with FOP typically have malformed toes at birth, meaning the big toe is typically shorter than normal and abnormally turned outward in a position called a valgus deviation. Symptoms of FOP start to show up in early childhood. Most people with FOP develop painful tumor-like swellings also known as fibrous nodules. The fibrous nodules are visible on the neck, shoulders, and back.
The gene which is responsible for this disease, FGFR3, is located on chromosome 4 at 16.3, which is on the short arm near the telomere (4). Under normal circumstances, this gene forms fibroblast growth receptor 3 which interacts with a protein to begin a stream of signals that contribute to bone development and maintanence; it is also thought that this gene is also important in other tissue development (6, 7, 10-12). Some of the known pathways involved with FGFR3 are STAT1/3, STAT5, MEK1, ERK1, and MAP kinase signaling. Chondrogenesis and osteogenesis are two processes managed by these pathways and are greatly affected by a mutation (13-15). The sections of these pathways that involve and are affected by the mut...
So far, various techniques have been used for reconstruction and regeneration of maxillary and mandibular bone defects. Autogenous bone grafting, guided bone regeneration (GBR), distraction osteogenesis and nerve transpositioning are among these regenerative techniques (1-8). Decision making for the treatment could be influenced by the type, size and location of the bone defects (2, 3, 9, 10). GBR had high success rate in treating small alveolar defects such as dehiscence or fenestration. Regenerative bony walls around the defect with ingrowing blood vessels can begin osteogenesis (11) larger bone defects with insufficient regenerative walls and an low quality avascular bed need varied amount of autogeneous bone graft from extra oral or intra oral donor sites, however, the patient may suffer from complications in donor site as well as bone graft resorption.(10, 12-15)
There are many different diseases that can affect our skeletal system and Osteoporosis is one of them. Osteoporosis lessens bone strength and bone density (amount of bone mineral in bone tissue), which will lead to fragile bones. It mainly affect the hips, ribs, spine, and wrists. Male or female, at any age, can get this but it is mostly occurs in older women (Team, 2016). Osteoporosis is very common, there are more than 3 million cases a year. There are many causes/risk factors, symptoms, and some treatment cases. About 54 million Americans have Osteoporosis and low bone mass (Foundation, 2016).
Muscular Dystrophy is a genetic disorder in which your muscles drastically weaken over time. Muscles are replaced with “connective tissue,” which is more of a fatty tissue than a muscular one. The connective tissue is the tissue that is commonly found in scars, and that same tissue is incapable of movement. Although Muscular Dystrophy affects muscles in general, other types affect certain groups of muscles, and happen at different periods throughout a lifetime. For example one of the most common types, Duchenne Muscular Dystrophy, targets muscles in the upper thigh and pelvis. The disease is displayed throughout early childhood, usually between ages four and seven. This genetic disorder occurs only in boys. People have difficulty sitting up or standing and lose their ability to walk in their early teens. Sadly most people die by the age of twenty. A second common type, Becker’s Muscular Dystrophy affects the same muscles as Duchenne, but first appears in teenage years. Most people with Becker’s only live into their forties (Fallon 1824-1825).
It is associated with a higher risk of pregnancy complications and certain ovarian cancers. Due to the importance of this condition, it is critical that patients understand its causes, symptoms, and treatment. By the end of this article, you will have the answers to these essential questions:
It is estimated that 1 out of every 5,600-7,700 boys ages 5-24 have Duchene or Becker muscular dystrophy. (“Data & Statistics,” 2012 April 6) Muscular dystrophy is a group of genetic diseases defined by muscle fibers that are unusually susceptible to damage. There are several different types of muscular dystrophy some of which shorten the affected person’s lifespan. (“Muscular dystrophy: Types and Causes of each form,” n.d.) There is a long history of the disorder but until recently there wasn’t much knowledge of the cause. (“Muscular Dystrophy: Hope through Research,” 16 April 2014) Symptoms are obvious and can be seen as soon as a child starts walking. (“Muscular Dystrophy,” 2012 January 19) Although muscular dystrophy mostly affects boys, girls can get it too. (“Muscular Dystrophy,” 2012 January 19) There is no cure for muscular dystrophy but there are several types of therapy and most types of muscular dystrophy are still fatal. (“Muscular Dystrophy: Hope through Research,” 16 April 2014)
Osteogenesis imperfecta (OI), also known as brittle bone disease, is a rare genetic disorder with the main characteristic being that the bones break very easily, usually for no apparent reason. The major cause of osteogenesis imperfecta is a mutation in the genes that produce collagen. Collagen is the main protein that works toward the production of connective tissue. Individuals with this disorder will produce less collagen than needed, which causes the bone development to be endangered. This could result in bone deformities. There are four types of osteogenesis imperfecta, and in all four types you will see bone fragility with multiple fractures and bone deformities.
The syndrome is caused because of Genetic mutation that replaces connective tissues (muscles) with bones when someone gets injured instead of getting cured. This results in a new skeletal structure. Unfortunately this syndrome does not have any cure and the patients are advised to always be careful and not to fall or have any kind of traumas. They can’t engage in any sports in order to prevent any injuries. Surgery for removal of extra bones is not an option because removal of bones will lead to ingrowth of more bones. From previous cases it is seen that most of the patients suffering from this condition do not live more than 40 years and they die of respiratory
The purpose the study is the presentation of successful use of Signafuse Bone Graft Putty in vivo. Fusion Products are commonly used in the field of Orthopaedics. They serve an important role as far as relieving pain and treating morbidities.
Fractures are life-threatening to aged people having the metabolic bone disease OSTEOPOROSIS, in which bones become porous and brittle. A person, mostly women, having osteoporosis may break a hip during a fall and possibly die from complications. Birth Defects Congenital bone diseases constitute a wide spectrum, ranging from the unimportant--for instance, mild bow legs--to severe lesions, such as spina bifida, in which the lower end of the spine fails to develop properly and the baby is born with paralysis and misshapen vertebrae. Congenital diseases may have hormonal bases: for example, fibrous DYSPLASIA, in which fibrous tissue replaces that of some bones, often results in bone deformity; in addition, some girls with this disease physically mature so early that they are capable of pregnancy and childbirth at the age of seven.
A broken bone is one of the worst and most painful injuries you can suffer. Broken bones can be caused by many different things such as falling on it or even a hard-twisting motion. Bones can be easily viewed as a solid, non-working part of our body where tissue just sits, but your skeletal system is as much a living part as your organs. Your body stores minerals in the compact bone, and stores fat in the yellow marrow. Your bone also has the ability to produce red blood cells in the inner part, the red marrow. Your bones can do many great things, including healing themselves. The process of healing themselves is complex and can take a lengthy period of time.
Pulmonary Fibrosis is a condition where the lung tissue becomes thick and scarred. The thickening and scarring of the lungs makes it hard for the oxygen supply to be delivered throughout the body. The scarring can be caused by many different factors, but it is hard for doctors to figure out exactly what caused the onset of this disease. The damage caused by this disease cannot be repaired. Pulmonary Fibrosis usually affects the age group of forty to seventy years old. Men are more likely to develop this disease, but women can also get this disease. Pulmonary Fibrosis is not a transmittable disease. Little is actually known about how the disease develops. There seems to be a genetic connection and environmental factors that cause the disease to develop.
If you and a surgeon have decided that surgery is your best option to achieve a full recovery, then it is best to be informed of all surgical options. There are two primary surgical methods: plates and pins. There are advantages and disadvantages to both options, and they serve different functions.
Dystrophic epidermolysis bullosa is one of the major forms of Epidermolysis Bullosa. In minor cases, blistering affects the hands, feet, knees, and elbows. Severe cases involve widespread blistering that can lead to vision loss, disfigurement, and other serious medical problems. DEB is caused by changes in the type VII collagen gene that may be inherited as a dominant or recessive subtype. Some patients might even need nutritional supplements, occupational therapy or surgery depending on the severity of their condition. The article addresses the current standards of managing chronic wounds in DEB as well as developing therapies that may possibly lead to the ability to cure this heritable skin disease.