Epigenetic Synthesis

1345 Words3 Pages

There is no surprise that food is important in all aspects of our lives—it is shared amongst families, celebrated as a major part of our culture, and crucial to our daily routine that keeps us fit, healthy, and active. Today’s western culture glorifies a skewed perspective on how food is supposed to fit into our lives. Somehow this perception has led us to believe we no longer have the time or money it takes to prepare a wholesome, healthy meal that is shared at the dinner table with family. Instead, we are trained to want a meal that is fast, cheap, and easy. This meal is usually highly processed and filled with sugars and fats. This has led us to a problem of epidemic proportions characterized by the rapid increase in obesity and diabetes. …show more content…

One of the most commonly described mechanisms is altered DNA methylation, which has been noted in paternal folate deficiency7, maternal under-nourishment during pregnancy6,7, paternal high fat diets2, and paternal low protein diets3. Another mechanism is established by microRNA’s ability to regulate DNA methylation. Certain microRNA’s are known to downregulate DNA methyltransferase enzymes that function to maintain global methylation status in the genome.6 It has been proposed that environmental exposures, like nutrition, can change sperm microRNAs leading to modifications in DNA methylation.11 Histone modifications in spermatids, such as acetylation, occur in another commonly described mechanism. These diet related changes affects the structure of chromatin, which can lead to increased risk damage to DNA and thus poor sperm outcomes.6 Further influences that lead to epigenetic changes during spermatogenesis include the following: increased testicular temperature, hyperleptinemia, hyperinsulinemia, and genotoxic metabolites due to paternal fat accumulation causing increased oxidative injury to sperm cell DNA.6 These epigenetic changes are thought to influence and accelerate genetic variation that is thought to drive the evolution of a

Open Document