Chrioamnionitis Research Paper

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Nearly 10% of all births are classified as preterm (1). Whilst improvements in medical care for preterm newborns have improved survival rates, prematurity still accounts for up to 70% of perinatal death and nearly 50% of poor chronic neurologic outcome and cerebral palsy (CP). CP is therefore the most common cause of chronic disability in children (2). In Australia, a baby is born with a brain injury that underlies CP every 15 hours. This condition is characterised by damage to the developing brain causing motor and postural impairments that inevitably lowers the patient’s quality of life. The majority of these cases occur before 37 weeks of gestation due brain immaturity and susceptibility to maternal and fetal complications (3). Of these …show more content…

Chorioamnionitis is associated with pregnancies which have been further complicated by premature rupture of membranes (PROM) and spontaneous delivery (3). PROM does not have to be present to be diagnosed with chorio; more than a third of patients that deliver preterm will have intact placental membranes, yet 13% of these patients will later be diagnosed with chorioamnionitis (4). Nevertheless the addition of PROM increases the chances of acquiring chorio during pregnancy. PROM it is the most easily identifiable risk factor for the condition, along with vaginal bacterial abnormalities, meconium stained amniotic fluid, prologued labour and other factors that make the mother susceptible to …show more content…

Prostaglandin release stimulates uterine contraction, which cause the baby to move down the birth canal and weaken the membranes. Metalloproteases initiate the degradation of the chorion and amnion that inevitably cause them to rupture.
Preterm chorioamnionitis causes inflammation and injury to the brain and increases the risk of intraventricular haemorrhage and diffuse white matter injury (6). With no treatments available to protect the baby from the infection, most cases involving ruptured membranes require the baby to be delivered early to reduce the risk of further complication. However, by the time of delivery, the baby has been exposed to infection and the associated risks to the developing brain, not to mention the risk of preterm delivery itself.
Fetal inflammatory response

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