1.1 DRUG INTRODUCTION
Antiplatelet drug are used to treat heart disease. They are powerful medications that prevent the formation of blood clots. When you are wounded, platelets arrive on the scene and group together, forming a blood clot that stops the bleeding. When an injury involves a break in your skin, this is a good thing. But platelets can also aggregate when injury to a blood vessel occurs from within the inside, as may happen in an artery affected by atherosclerosis. In this situation, the platelets cause blood clots to develop in an already injured artery. Antiplatelet medications can prevent this process from happening.
Antiplatelet may be prescribed for patients with a history of:
- Coronary artery disease
- Heart attack
- Angina (chest pain)
- Stroke and transient ischemic attacks (TIAs)
- Peripheral artery disease
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o Antithrombotic derives from reduction in thromboxane A2. o Aspirin also has analgesic, anti inflammatory and antioxidant properties. Some of the beneficial actions of aspirin in patients with cardiovascular disease (CVD) may be related to these as well as its antithrombotic effect. However, some of these effects are only apparent at much higher doses.
CLOPIDOGREL
An ADP receptor antagonist that competitively inhibits ADP from binding to platelet receptor, preventing ADP-mediated up regulation of glycoprotein (GP) IIb/IIa receptor, again blocking amplification of platelet aggregation. o Direct comparison of Clopidogrel may indicate that it is a slightly more effective Antiplatelet drug than aspirin. o More importantly, Clopidogrel is routinely used In the treatment of acute coronary syndrome (ACS) and post percutaneous coronary intervention (PCI) stenting in conjunction with aspirin.
PRASUGREL
Ace Inhibitors are used to treat hypertension and congestive heart failure (CHF). Most of the drugs that are Ace Inhibitors have the common ending –pril. It inhibits an enzyme; that decreases the tension of blood vessels and the blood volume, thus lowering blood pressure. Lotensin (benzapril) comes in tablets and is used for oral administration. It is one of the ace inhibitors that are indicated for treating hypertension. There is warning while using Lotensin when pregnant, it indicates to stop using immediately when pregnancy is detected. Vasotec (enalpril) comes in tablets and injection. It is indicated for the treatment of hypertension and is effective alone or in combination with other Ace Inhibitors agents, especially thiazide-type diuretics. There is a warning for fetal toxicity; when pregnancy is detected; stop using.
Is the five-paragraph essay taught throughout high school and college more harmful or hurtful to students? According to John Warner in his article “Kill the 5-Paragaph Essay,” the schools should eliminate the five-paragraph essay, for the essay is more harmful to the students than it is helpful. He states how the five-paragraph essay turns into a “Frankenstein’s monster” and “lurches and moans across the landscape, frightening the villagers” (Warner). This comparison demonstrates Warner’s disapproval towards the essay and shows that the “essay” no longer looks like an essay but looks more frightening. Warner then states how writing should instead be “done for audiences” rather than a “performance meant to impress a teacher or score well on a
Aspirin has grown so much in popularity that about 35,000 metric tons of it is produced and consumed each year to meet the consumer’s demand. 35,000 metric tons is equivalent to 100 billion standard aspirin tablets (10). That many tablets means that the market for aspirin is very good. Today, Aspirin is known as the leading non-prescription medicine of all time. It is the most common pill taken for pain, inflammation and fever. It has grown all over the world, being made available in eighty countries (9). It would not be surprising if one day, all the countries would have aspirin available to them.
Many factors can increase the risk of these clots, including prolonged bed rest (such as after surgery), sitting for long periods (such as on a plane), use of birth control pills or hormone replacement therapy, pregnancy, family history of DVT, inflammatory bowel disease, and certain genetic clotting disorders. Compression stockings are also sometimes used in people who have an acute DVT, to prevent a group of symptoms known as post-thrombotic syndrome that includes leg pain and
Atherothrombosis is the pathophysiologic hallmark of acute coronary syndrome which can lead to an acute myocardial infarction. Platelet aggregation is one of the major reasons why ACS occurs, arterial plaque builds up over time from products such as lipids, cholesterol and fibrin. The vasa vasorum
Aspirin contains the substance acetylsalicylic acid (ASA), which can relieve inflammation, fever, pain, and known as a “blood thinner”. Aspirin was not officially trademarked until March 6, 1899 when the Imperial Office of Berlin made it official. It has been used for the last 110 years, but its natural form, salicylic acid has been around for thousands by Egyptians, Greeks, and Romans. Aspirin is available in over 80 countries and known as the best non-prescription drug. The most common use of aspirin is to cure headaches and use it as a pain reliever, but aspirin is known to prevent heart attack and strokes. It was first proposed in 1940, but wasn’t confirmed until 1970 when doctors would recommend taking aspirin daily [1].
The next stage in myocardial infarction is the formation of thrombus. Exposure of the subendothelial matrix of the plaque to blood due to superficial abrasion generates platelet activation and aggregation. Clotting factors on the platelet membrane carry out reaction which release prothrombin activator, this activator then converts prothrombin to enzyme thrombin. The transformation of fibrinogen to fibrin is then catalysed by thrombin. During proteolysis (the breaks down of protein), fibrinogen is converted to fibrin strands which stabilize the final blood clot. Complete occlusion of coronary artery by thrombus disrupts blood flow and causes ischemia due to atherosclerotic coronary artery steno...
Hemophilia is a rare bleeding disorder that slows the blood clotting process, which is not normal. Some people with Hemophilia may just have a little bit of “clotting factor” or no clotting factor at all (National Institute of Health [NIH], 2013). Clotting factor is a protein in blood that controls bleeding and they are needed the blood to clot normally. In order to help the blood clot, clotting factors work with “platelets” (National Institute of Health [NIH], 2013). Platelets are small blood cell fragments that form in the bone marrow, a tissue in the bones that is similar to a sponge. The functions of platelets have a very important role in blood clotting; the role of a platelet is to stick together (by the help of clotting factors) to block cuts, break on the carriers of blood (veins or arteries) throughout the body, and stop the bleeding when “blood vessels” (National Institutes of Health [NIH], 2013) are injured. Blood vessels are tube like structures carrying blood through the tissues and organs, like a vein, artery, or capillary. People with hemophilia do not have enough “clotting factor VIII or IX” (World Federation of Hemophilia [WFH], 2013) in their blood, which results to prolonged bleeding or oozing, meaning that bleeding can last longer (though, not faster) than usual after surgeries, accidents, or having teeth pulled out at the dentist. Clotting factor VIII, which can also be called as “anti-hemophilic factor” (AHF, for short) (Patient.co.uk, 2011), is a blood clotting protein that is necessary for humans to have. Clotting Factor IX is a protein that i...
Blood clots can accumulate due to atherosclerosis plaque buildup. When plaque builds up and break off in the artery a blood clot can form. If the blood clot is large enough, it can particularly or completely block the artery. A blocked artery segment is what causes tissue death due to deprived oxygenated blood. If this problem is not treated right away, the portion of the heart fed by the artery will begin to die. Scar tissue will form on what was once health heart tissue. The heart damage may not be noticeable, or it may cause severe or long-lasting problems. (National Heart, Lung, and Blood Institute) Another cause of heart attacks is due to a severe coronary artery spasm, this is this least common cause. Coronary artery spasms are brief temporary tightening or contraction of the muscles in the artery wall. Spasms can emerge in coronary arteries that aren 't affected by atherosclerosis. It 's not clear as to why these spasms arise but they are most likely due to: physical exertion, emotional stress or pain, exposure to extreme cold, cigarette smoking, cocaine
The aim of this paper is to take an in-depth look at the emotion of disgust, and explore what role (if any) it should play in morality. The issue of what role disgust should have in morality is disputed by advocates and skeptics. In what follows, I will outline this dispute and show the arguments each side makes. Following that, I will take a look into Kelly’s view which takes the skeptical stance, but differs in how he comes to take that stance. Next I will show how Kelly uses his view to disprove the disgust advocates’ arguments. Finally, I will illustrate a promising line of argument that may give hope to the disgust advocates, in light of Kelly’s powerful skeptical stance.
Ally most likely has used ACE inhibitors and Beta blockers in the past and will be using them again.. The ACE inhibitors are vasodilators with the capability to widen the blood vessels allowing the blood pressure to lower down while improving the blood flow and decreasing the workload of the heart (WEbMD, 2017). Lisinopril is anangiotensin converting enzyme. This drug is used to treat high blood pressure, heart failure, helps to preent kidney failure --due to high blood pressure and diabetes. It is also used to prevent further damage and scarring of the muscles (Medicine Net, 2017). Another Ace inhibitor is Benazepril. It is used with hydrochlothiazide, at times, to treat high blood pressure. It can also be used to treat heart failure. Beta blockers are medications that lower your blood pressure.Beta blockerd work by blocking the effects of the hormone epinephrine. Two types of Beta blockers are Metoprolol relaxes blood vessels and slows down the heart rate and Nebivolol, which response to nerve impulses in certain parts of the body,like the heart (Mayo Clinic Staff). This helps to lower heart beats and decrease the blood pressure (Mayo Clinic Staff,
Platelets, which are also produced in the bone barrow, are checked on a Complete Blood Count with Differential. Platelets help stop bleeding from injury by creating clots. If your CBC blood test shows low platelet levels, you might be more susceptible to bleeding. High platelet levels could mean that you have an increased risk of internal clots.
Background Information Aspirin is an analgesic (pain relieving) and an antipyretic drug (a drug that lowers body temperature). The main constituent of aspirin is 2 - ethanoythydroxybenzoic acid, also known as acetylsalicyclic acid (shown below right). It was originally made from just salicylic acid (which is found in the bark of a willow tree) when used by the Ancient Greeks to counter fever and pain, but its bitterness and tendency to irritate the stomach caused problems. These were resolved by the German chemist Felix Hoffman, who made the acetyl derivative of salicylic acid in the
First Aid for bleeding begins by calming and reassureing the victim. Next lay the victim down to reduce the chance of fainting by increasing the blood flow to the brain. Elevate the bleeding area when possible. Clean and remove loose dirt away from the wound. If an object such as a knife, stick, or arrow becomes embedded in the body, do not remove it. Doing so may increase the amount of bleeding and cause more damage. Place gauze and bandages around the object and tape the object in place. Put pressure directly on an external wound with a sterile bandage, clean cloth, or even a piece of clothing. Direct pressure is best for external bleeding, except for an eye injury. Maintain pressure until the bleeding stops. Do not peek at the wound to see if the bleeding has stopped. If bleeding continues and soaks through the material being held on the wound, do not remove it. Simply place another cloth over the first one. Be sure to seek medical attention.
The United States is a country full of people from different backgrounds and beliefs with dreams of endless possibilities. Every single person is uniquely different in every way. Millennials are the luckiest people of America. They learn from their parents mistakes and have more opportunities than them. They get to choose their own career, sexual orientation, religion, and basic beliefs. One of those choices is their living arrangement. Many millennials would rather purchase experiences than things. This way of life is called Minimalism. The minimalistic lifestyle ignores the societal pressure to purchase the latest fashion trends. Minimalists focus on their personal goals in life and are not attached to physical belongings. Hoarders,