The human body can be thought of as an intricate machine and the brain as the control panel. This complex organ that has kept scientists and philosophers involved over the centuries ultimately controls how we function. The brain, to me, is the most interesting thing in the universe. However, much is still undiscovered and therefore it intrigues us to learn more about this vital organ. My fascination with the brain arose while taking introductory biology and psychology courses. My deepened interest towards the neural basis of memory and learning and its impacts on neurodegenerative diseases such as Alzheimer’s eventually lead me to attain an undergraduate research opportunity in the Mizumori laboratory.
The Mizumori laboratory’s primary focus is to understand the neural mechanism of natural and adaptive behaviors. Spatial navigation, a behavior central for an animal’s survival has remained the model under analysis in this lab. Consequently, dysfunction of key components of the underlying neural circuitry could lead to catastrophic effects, which is markedly seen in disorders such as Alzheimer’s disease, Parkinson’s disease, substance abuse, and schizophrenia (Cools et al, 2010;
…show more content…
The hippocampus, as observed in voluminous studies associated with dementia, plays an important role in episodic memory (Aggleton and Brown, 1999; Ball, 1977). The aim of this larger project that I will participate in will focus on understanding how and in which instances the LHb is engaged when switching behaviors. Ultimately, through these projects we hope to advocate a new role for the LHb in guiding behaviors, which in turn should offer new avenues of research into how to treat impairments in cognition across a number of diseases. It also will require reevaluation of how the brain processes complex cues in order to guide
Eichenbaum, H., Otto, T., & Cohen, N. J. (1992). The hippocampus—what does it do? Behavioral
Organized in the class Actinopterygii, seahorses, Hippocampus spp., are marine dwelling organisms found in bodies of water which span from tropical to temperate zones around the Earth. As cited by Foster in Life History and Ecology of Seahorses, research by R. A. Fritschze suggests that the genus Hippocampus diverged at least 20 million years ago from its ancestral origins. Research pertaining to organisms organized under the genus Hippocampus are conflicting in regards to the number species contained within it, although a general figure places the number at around fifty discovered species(website source). These odd-looking organisms reside at shallow depths of less than 30 meters and can be found in habitats containing seagrass beds and coral reefs(Foster 10). Hippocampus spp. are all predatory organisms, their main sources of food consist of small crustaceans and fish, as well as other organisms which are small enough to be consumed(lourie 10). Although Hippocampus spp. are predatory, their size and restricted mobility capabilities place them at risk of being prey for other carnivorous organisms.
The hippocampus has been associated with memory formation and consolidation, through lesions studies of bilateral medial temporal lobectomy patients, such as the famously amnesic H.M. In 1971 with the discovery of place cells by O’Keefe and Dostrovsky, spatial navigation was recognised as one of the primary roles of the hippocampus, with their 1978 book ‘The Hippocampus as a Cognitive Map' O’Keefe and Nadel’s hypothesis has since commanded great influence in the field.
Discussed by Cipolotti & Bird (2006), LTM impairments can lead to anterograde and retrograde amnesia if the medial temporal lobe (MTL) is damaged bilaterally. Specifically, the two most important types of LTM related to anterograde and retrograde amnesia are episodic and semantic memories. Conversely, many researchers have long debated the true functions of the hippocampus and have allowed two theories to emerge. The standard model of consolidation (SMC) assumes that the hippocampus is important in consolidating LTM, while the multiple trace theory (MTT) argues that information is encoded by specific memory traces by the hippocampus. These two theories help further explain the vast functions of the hippocampus.
Through studies performed on sleep-deprived rats, experimental results have shown a decrease in cellular activity in the hippocampus. The hippocampus is responsible for most of the brain’s memory processing. When entering into sleep deprivation, the brain will experience consequences such as a failure for the hippocampus to encode, consolidate, or retrieve signals powering memory processing. As a result, researchers are looking for cellular characteristics that could lead to further details into the relationship between sleep deprivation and memory impairment. There are several different ways memory can be disrupted, one suggested in being an imbalance of neurotransmitters in the hippocampal region of the brain. Both hormonal and oxidative stress are also factors that are observed to play major roles of memory impairment in the hippocampus. These
According to these two cases, these inspire us to understand that the hippocampus is an important brain region that is used for converting short-term memory into long-term memory.
Definition of memory and it's functions is difficult to illustrate by a single sentence. Consequently we use several metaphors to describe memory implicitly. Our beliefs, perceptions and imagination influence memory. The fact gave rise to memory being described as a reconstructive process, explaining that memory is not an exact record of a particular experience. Instead we bring various components together and fill in the blanks with our predisposed schemas while recalling. The metaphor building "an entire dinosaur skeleton from fossils" is the indirect way to describe memory as cognitive reconstruction. Remembering includes using schemas which are the mental representations of a concept, person or an event.They rejuvenate an incomplete memory such that it is perceived to be an undiminished one. Of course there are errors experienced when recalling which supports the idea of imperfect memory. These can be errors of commission, adding details which were not a part of the experience and errors of omission, which is excluding some aspects of the experience. In this paper I will support the selected metaphor and will provide evidence approving it.
Memory plays a significant role in the everyday lives of people of all ages. It allows them to recall information and remember skills that were learned in the past. Memory also organizes past information to help people make current and future decisions. However, imagine forgetting the names of close family members or not having the ability to find your keys every time you want to leave the house. These are some of the struggles that people with Alzheimer’s disease face daily. Alzheimer’s disease was first identified by German neurologist Alois Alzheimer in 1906, and was discovered to have an overpowering effect on explicit memory loss (Gruetzner, 1988). There are two types of Alzheimer’s disease – early onset and late onset. Early onset occurs in patients who are diagnosed before the age of 65 whereas late onset occurs in patients who are diagnosed after the age of 65. In the early stages of Alzheimer’s disease, short-term memory is often lost. As Alzheimer’s disease progresses, problems with long-term memory begin to develop, in addition to short-term memory impairments. Although a lot is known about the symptoms of Alzheimer’s disease, the cause has not been conclusively identified. However, as research continues, new theories about the cause of Alzheimer’s disease are being proposed. This has led to a controversy over whether Alzheimer’s disease is caused by genetics or environmental influences (Gruetzner, 1988).
management of real-world memory demands despite profound anterograde amnesia. Journal of Clinical & Experimental Neuropsychology, 30(8), 931-945.
The question then becomes whether declarative and non-declarative memory are in fact separate or different manifestations of the same neural process. From research on H.M., we find evidence for the existence of a declarative memory system that is independent of non-declarative memory and other forms of intelligence. H.M. had the capacity to hold information in his head for a period of time, suggesting that his working memory was intact (Squire and Wixted, 2011). Further evidence that not all memory is the same is the fact that H.M. acquired a motor skill despite not being able to remember actually learning the skill, thus showing the difference between episodic and semantic memory. Amnesiacs are able to acquire the perceptual skill of reading mirror-reversed words at a normal rate compared to controls (Cohen and Squire, 1980), demonstrating that the ability to learn new perceptual skills also remains intact. Of the forms of non-declarative memory, procedural memory involves the cerebellum, motor cortex, and basal ganglia (General Intro the Neurobiology…). Thus, non-declarative memory can, in a way, be seen as a more primitive form of memory that is not acquired through the integration and consolidation of neural events in the medial temporal lobe, but rather through learned associations outside of the
Making and storing memories is a complex process involving many regions of the brain. (3). Most experts agree that we have two stages of memories - short-term memory and long-term memory. Short-term memory is the immediate memory we have when we first hear or perceive someth...
Hippocampus plays an important job in the formation of new memories about experienced events such as the episodic or the autobiographical memory. It is also a part of larger medial temporal lobe memory system responsible for general declarative memory. General declarative memory is a type of memories that can be explicitly verbalized. If damage to hippocampus occurs only in one hemisphere, our brain can still retain near-normal memory functioning. But even so the hippocampus is damage; some types of memory such as abilities to learn new skills will not be affected. The reason is because, some abilities depends on different types of memory and different regions of the brain such as procedural memory. Hippocampus also plays role in spatial memory and navigation. Many hippocampal neurons have “place fields” and the discovery of place cells in 1970’s led to the theory that hippocampus might act as cognitive
Most of the body’s functions such as, thinking, emotions, memories and so forth are controlled by the brain. It serves as a central nervous system in the human body. The mind is the intellect/consciousness that originates in the human brain and manifests itself in emotions, thoughts, perceptions and so forth. This means that the brain is the key interpreter of the mind’s content. Jackson and Nagel seem to resist identifying what we call “mental events” with brain events, for different reasons, while J.J.C. Smart takes the opposing view.
In the field of cognitive neuroscience a memory study usually involves a combination of behavioral tasks and a machine that permits t...
Highlighting this concept is the case of Susie Mckinnon, who lacks episodic memory. Though she lacks episodic memory, she does have intact semantic memory, which is another form of explicit long term memory. The WIRED article by Erika Hayasaki, reflects Mckinnon’s unique perspective and how she was able to become aware of her deficiency, as she was not uniquely aware something was wrong with her until high school and further research. By analyzing Mckinnon’s case in respect to the findings of Allen and Fortin, this allows one to understand why episodic memory is evolutionarily important for functionality and interactions in daily life.