Kielstein and Hans‐Martin give a case example of a 55 year old female dialysis patient who was diagnosed as a carrier of a dominant genetic disorder: Autosomal dominant polycystic kidney disease (ADPKD). She had four sons who underwent screening and were identified as carriers. One of her sons was 32 years old and the father of a six year old when he first developed symptoms of ADPKD. He committed suicide. Another son, who was 30 years old, divorced his wife and sold their home to keep from burdening her or planning a family. He did not have problems until he was 54. A third son was 25 and left his fiancée for the same reason. He later died from another cause without having ever developed symptoms. The fourth son was 21 when identified as a
Huntington's Disease and Its Ethics In “Genetics and Reproductive Risk: Can having children be immoral,” L.M Purdy discusses the notion that the recent advances in reproductive technology impose a moral obligation on individuals to prevent the birth of “affected” babies that will not have a “minimally satisfying life.” There are, however, several assumptions that the author makes in reaching the conclusion that having “affected” children is immoral. The author makes the claim that people with Huntington’s disease are unlikely to live a minimally satisfying life. It is known however, that Huntington’s disease does not take any affect until 40-50 years of age.
In the book it says "They can spend a whole lifetime worrying whether they 're carriers, and then we come along and offer them a test. Recessives and X-linked. Look what they 're doing with fragile-X nowadays. And cystic fibrosis. Just imagine the commercial possibilities if you can design and patent a probe for something like Gaucher 's disease...(69)" Recessive traits is the phenotype is seen only a homozygous recessive genotype for the traits of the interest is present. The booked talked about two of three diseases that are most common in the Ashkenazi Jewish population. The first one is Cystic fibrosis which is an inherited life-threatening disorder that effects the lungs and the digestive system. The other one mention in the book that wasn’t mention in class was Gaucher 's disease. Gaucher 's disease is a build up of fatty substances in your organs, usually in you spleen and liver. Which causes them to become bigger affecting their function. The last one that we learned in class was Tay-Sachs disease, which is a rare inherited disorder that destroys nerve cells in the brain and spinal
Vanguard Case Analysis After reading through the Vanguard case, there were a few difficult forks in the road that Vanguard seems to be facing. The company’s future can be greatly affected by some of these difficult choices. Vanguard has to decide whether to change their investment offerings, further develop Internationally, or to simply advertise to increase their client base. Top managers at Vanguard have to step up to the plate and rollout detailed plans as to what path the company should take regarding some of these issues. Through our in-class discussions, the majority of the students argued on one major problem that Vanguard was facing.
Chronic illness can be very difficult to manage. Cystic fibrosis is the most common life-limiting autosomal (not sex-linked) recessive disease among Caucasian heritage. Although technically a rare disease, it is ranked as one of the most wide spread life-shortening genetic diseases. It is most common among nations in the Western world minus the exception of Finland but it is equally diagnosed between male and female.
In Laura Purdy’s account of Genetics and Reproductive Risks: Can Having Children Be Immoral?, Purdy’s claim is that conception of a child is immoral when there is reasonable concern of a genetic disorder and if prenatal screening is not done to see how likely it is for your child to obtain that disease, then it is wrong. Purdy thinks it is immoral to reproduce when we are at high risk of transmitting a disease or defect and she says it is wrong to reproduce without knowing the consequences of our genome. The birth of a child at risk of a serious defect could be prevented by abortion or preventing conception of a child. And conception is only allowable once a person has undergone a prenatal screening and if a selective abortion would be done, and for those who are against abortion must be extremely careful not to conceive.
The patient is a Caucasian female of catholic religion. She is married with two other children, and has just given birth to her third child. The other two children are both two and four. This particular family does fit into the traditional nuclear family model, as there are two parents in the family structure both of whom have a stable and steady occupation and live together in the same house. The patient did not mention whether ...
The presence of a mutated gene may not be noted until a woman with no family
In “ Sounding Board Death and Dignity, A Case of Individualized Decision Making” by Timothy E. Quill talks about a patient of his named Diane. An ordinary person but has struggled with alcoholism and depression. Quill then, with vigorous testes, finds out she has acute leukemia. Now knowing this, Quill and other doctors advised Diane about undergoing treatment as soon as possible. But she refused and just wanted to go home and be with her family. Though at this time she was not experiencing any suffering as ...
If two parents get tested and find out that their child could have the disease, they could choose to get an abortion, which would be abusing the benefits of genetic testing. In the Jewish testing article it says “or they may choose to end the pregnancy” (Goldschmidt). In this case, taking the life of an unborn child due to genetic testing is an example of how genetic testing can be morally unsound. Also, if a cure is found for genetic testing, the treatments can be very harsh. In the Patients in Limbo article is says “every month for the first two years of her life” (Marcus). Although a cure was found, this child had to undergo extreme treatment in order to have the chance of being cured for the condition. As just a young child, depending on the type of treatment it is, this can be too extreme for such a young patient and can deteriorate the young ones body. In this situation, although genetic testing led to results, it also led to things that can cause pain and suffering, which is not what genetic testing should be used to
Watson, S.L. (2008). Something you have to do – Why do parents of children with
Since the gene for HD is dominant, there is a 50% chance of a sufferer's
In a survey of 999 people who sought genetic counseling conducted by Feighanne Hathaway, M.S., of New York University Langone Medical Center, and colleagues, “Most were eager for a wider spectrum of prenatal genetic tests -- as long as they were for disease” (Smith).
BASF is one of the world's largest chemical companies. It was established in 1865 with the main product was coal tar based dyestuff. It has six main categories of products, which are oil and gas, chemicals, agricultural products, plastics and fibers, dyestuff and finishing products, and consumer products. The structure of the company is presented by three-dimensional matrix consisting of operating, regional and functional divisions. Since 1960, the company began to expand its operation at a global level through acquisition. In Southeast Asia, the company has over 30 companies in 16 countries through the region of which 12 have the production facility. Headquarter for the region is located in Singapore.
Genetic testing has become a highly controversial issue among both the general population and the scientific community. It is a process that exposes a person’s entire genome sequence, allowing it to be read and evaluated to identify potential risks for genetic diseases or diseases that could be passed onto offspring (Holt Productions, 2012). With thousands of genetic tests already being used, and more being established, it seems logical to put this growing technology to use. Some agree that it is a person’s right to know and understand his or her genetic makeup. However, others argue that, despite the benefits of genetic testing, caution should be used to carefully inspect the risks associated with this new technology.
The case under analysis, Eli Lilly & Company, will be covering the positives and negatives with regards to the business situation and strategy of Eli Lilly. One of the major pharmaceutical and health care companies in its industry, Lilly focused its efforts on the areas of "drug research, development, and marketed to the following areas: neuroscience, endocrinology, oncology, cardiovascular disease, and women's health." Having made a strong comeback in the 1990's due to its remarkably successful antidepressant Prozac, was now facing a potential loss in profits with its patent soon to expire. The problem was not only the soon to expire patent on Prozac, but the fact that Prozac accounted for as much as 30% of total revenue was the reality Eli Lilly now faced. (Pearce & Robinson, 34-1)