Preformulation Studies: (Deodatt A et al.,1980) Preformulation testing is the first step in rational development of dosage forms of drug substances. Prior to the development of the dosage form. It can be defined as investigation of physical and chemical properties of a drug substance alone and when combined with excipients. The overall objective of preformulation testing is to generate information useful to the formulator in developing stable and bioavailable dosage forms which can be mass produced. The goals of the program therefore are: 1. To establish the necessary physicochemical characteristics of new drug substances. 2. To determine its kinetics release rate profile. 3. To establish its compatibility with different excipients. Physical Characterization of Drug: (Indian Pharmacopoeia., 2007) The selected drug under investigation …show more content…
The physical studies were designed to ensure the stability of final formulation. The physical mixture of drug and lipids in the ratio of 1:1 was placed in glass vials, sealed and stored in 40ºc and 75% RH. The sample were withdrawn at pre determine time intervals of 15 and 21 day and examined for physical and chemical integrity of drug and Excipient. Parameter such as colour, odour or gas formation and aggregation were noted. The drug polymer compatibility was further confirmed by taking IR spectrum of drug, polymer and physical mixture of drug-lipid in ratio 1:1(Table:-) .The IR spectrum of physical mixture of drug-polymer was taken placing them in stability chamber at elevated temperature of 40ºC and 75% RH for 21 days. S.NO. Excipient Ratio 1 Tropicamide (drug) 1 2 Drug + Compritol 1:1 3 Drug + Stearic Acid 1:1 4 Drug + Glyceryl mono sterate 1:1 5 Drug +HPMC 1:1 Table:- Drug-Lipid Ratio for Compatibility Studies IR spectrum (Infra red
Students dread the time of the year when they stop with their course material and begin to prepare for test. Everyone is in agreement that some type of revolution is needed when it comes to education; eliminating standardized test will aid the reform. The need for standardized testing has proven to be ineffective and outdated; some leading educationalist also believe this because the tests do not measure a student’s true potential. This will save money, stop labeling, and alleviate stress in students and teachers.
The analysis is therefore one of the most effective methods of ensuring that each drug being prescribed to patients is safe. It also ensures that all drug components are understood in terms of their structure and chemical behavior. This understanding is very important in the manufacture of drugs and other pharmaceutical products.
Michele Obama once stated, “If my future were determined just by my performance on a standardized test, I wouldn 't be here. I guarantee you that.” The First Lady is, in other words, to say that standardized testing was a major factor into her life’s outcome and her scores could have potentially not put her in her position of power that she is highly recognized in today’s society. Although standardized tests do play a large role in any college application, standardized testing may not count as much toward one’s college admissions or success because standardized tests are not the only factor toward college applications, these tests only benefit a specific target group of people, and standardized tests are better used for giving insight on one’s
A scholarly journal written by an anonymous author sheds light on the importance of standardized testing by showing its efficiency in higher level education. This article provides a solid counterargument for the use of standardized tests which is standardized tests being a good source of predicting grades throughout college as well as whether students will stay long enough to graduate. It is also able to establish that the SAT is effective in forecasting a grade-point average through the fourth year as well as predicting students study habits. The
The overall purpose of schooling is to advance one’s knowledge and skill base and through standardized testing the belief is that one’s knowledge and skill base can be assessed and analyzed, but what occurs many a times is a teacher's difficulty to expand upon the learning process due to the confinements that testing has on his/hers ability to teach. In a qualitative study performed by the Morehead State University it was determined that in a particular rural school standardized testing had implemented a limit on the amount of time that teachers were able to instruct, as well as limitations on the “instructional resources and the types of assessments teachers employed” (Thomas, 2005). Even if a teacher was content with teaching the state
Since the U.S. Congress passed the No Child Left Behind program, standardized testing has become the norm for American schools. Under this system, each child attending a school is required to take a standardized test at specific grade points to assess their level of comprehension. Parents, scholars and all stakeholders involved take part in constant discussions over its effectiveness in evaluating students’ comprehension, teachers’ competency and the effects of the test on the education system. Though these tests were put in place to create equality, experts note that they have created more inequality in the classroom. In efforts to explore this issue further, this essay reviews two articles on standardized testing. This essay reviews the sentiments of the authors and their insight into standardized examination. The articles provide sufficient evidence to demonstrate that standardized tests are not effective at measuring a teacher’s competency because they do not take into account the school environment and its effect on the students.
To teach to the test or trust the child; is the question in today’s education. Over the past twenty years state curriculum standards have changed. Teachers need to make the choice on how to teach the children in their classroom. In today’s society where testing runs the educational world, a teacher must decide how to prepare students for standardized testing.
Size and stability: Liquid formulation can be bulky, difficult to transport and store.1 During storage under the stated conditions, it’s necessary that oral solutions are not subject to precipitation, fast sedimentation, caking or formation of lump.2 They have poor stability compare to solid dosage form formulation due to hydrolysis.1 Therefore, it’s important to optimize the active ingredient stability in liquid formulation including those prepared from powder or granules.2
Americans overwhelmingly think there is too much emphasis on standardized testing in public schools and that test scores are not the best way to judge schools, teachers or students, according to a national poll.
Pre-clinical testing is performed to Good laboratory practice (GLP) and covers pivotal toxicology & safety pharmacology studies. In preclinical research, scientists test their ideas for new biomedical prevention strategies in laboratory experiments or in animals.
outlines the benefits and risk reported in the tested population. For a drug to be approved by
The conical vial was placed in a small beaker and allowed to cool to room temperature. The mixture was Cooled thoroughly in an ice bath for 15-20 minutes and crystals collected by vacuum filtration on a Hirsch funnel. The vial was rinsed with about 5 mL of ice water and transferred into to the Hirsch funnel and again washed with two additional 5mL portions of ice water. Crystals were dried for 5-10 minutes by allowing air to be drawn through them while they remained on the Hirsch funnel. The product was transferred to a watch glass plate and allow the crystals to dry in air. Crude acetaminophen product was weighed and set aside a small sample for a melting point determination and a color comparison after the next step. Calculation of the percentage yield of crude acetaminophen (MW = 151.2). was done and recorded in the lab notebook.
Standardized testing remains to be a major controversial issue for the American society today. Exams are given to students at different levels in their educational career and are supposed to measure their academic knowledge, but are these tests really the best way to evaluate students? There have been numerous alternatives suggested to replace or be used in conjunction with standardized testing.
So what’s the big issue with traditional testing methods? They’ve been instituted for years and no one seemed to have a problem before now. Well, in the past decade, the nation’s citizens have become increasingly compassionate towards students and their individual needs. President George W. Bush has gotten generous praise for his No Child Left Behind Act of 2002 as a result of popular concerns among communities across the country. While the act may still have areas in need of improvement, it illustrates that educators, parents, and students alike have been desirous of reform within school systems. “The number of calls complaining about high-stakes exams coming from parents...are increasing, and is a reason for concern” (Report, 2001). The recent act caters to the actualization that students are different from one another, and in order for teaching and learning to take place in a non-discriminatory manner, adjustments must be made. According to the Educational Resources Information Center (ERIC), “Alternative assessment is any form of measuring what students know and are able to do other than traditional standardized tests. Alternative forms of assessment include portfolios that are collections of students' work over time, performance-based assessments, and other means of testing students such as open-ended essays with no single correct answer, and project work that involves collaboration with peers” (2000). Students learn in many ways. Some learn by listening to lessons and may prefer an environment with the aid of music and rhythm. Others may be visual learners who gather information by looking at photographs or watching videos. There are still others that learn kinesthetic...
Assessment is defined as “an exercise—such as a written test, portfolio, or experiment—that seeks to measure a student's skills or knowledge in a subject area” (edweek.com). Mainly today, we rely on multiple-choice exams, or tests that are easy to grade in a very generalized manner. The focus is mainly on math and reading, and requires remembering an assortment of different facts. Alternatives to these testing norms are often called alternative assessment. Alternative assessment is defined as “any form of measuring what students know and are able to do other than traditional standardized tests. Alternative forms of assessment include portfolios, performance-based assessments, and other means of testing students.” Performance-based assessment “requires students to perform hands-on tasks, such as writing an essay or conducting a science experiment. Such assessments are becoming increasingly common as alternatives to multiple-choice, machine-scored tests. Also known as authentic assessment.” This seems like an incredibly promising form of assessing an individual student, yet it remains less used because it is more involved. A portfolio is “a systematic and organized collection of a student's work throughout a course or class year. It measures the student's knowledge and skills and often includes some form of self-reflection by the student.” This is also used in many situations, but again, based on personal experience at many schools, the portfolios seem to have little influence on monitoring a students academic success. Measuring the performance of a student should be a completely holistic effort, and should be intensive. It may require a lot of work for the teacher, and qualifications would be ...