Every adult has around five litres of blood inside them, accounting for around 8% of their total body weight. Usage of donated blood by transfusion was a 20th century phenomenon and has become a long established therapeutic necessity. Around 2,000,000 units are transfused each year in UK, red cells remaining by far the most commonly transfused blood productL.
There are many areas in which blood transfusions come useful – such as serious injuries, illnesses, operations, childbirth – and in the case of red cells, often in the case of severe anaemia and blood loss.
With an ageing population and increased number of therapeutic interventions, comes many consequences. More elderly people now present with illnesses and for surgery – which have become more elaborate and extensive, increasing the need for supply and risk of complications. Unfortunately, demand outstrips supply, especially with the increase cardiac surgery and coronary heart disease, and changes in practice, especially involving chemotherapy and stem-cell transplant regimens.
As one’s own body loses own capacity to make adequate red cells – with our own genetics prevent their formation – the implications of not transfusing are otherwise catastrophic, with no viable alternative to improve oxygen-carrying capacity of the blood.
The increasing demand for supply requires the need for new approaches to recruitment and retentiont of future generations of donors.1 Spirally costs due to safety procedures in place make sure that that allogeneic red cells must be restricted as an asset. (SS) Despite such measures, there remains the risk of transmitting infectious diseases and developing an immune reaction to donated blood.
The NHS spends about £500 million on producing b...
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...lenging transfusion transmitted infections and need for immunological matching.
This well-established cellular therapy can only be set to be increased in use due to ageing population, evolved medical and surgical practice, redefined indications for its usage, and people’s increased perception of its safety.
One must seriously and innovatively about how best to attract and retain new blood donors as well as sourcing for alternatives. They must be deemed to be at low risk of infection transmission, the blood be collected using safe procedures, tested correctly for transmissible infections, tested for blood group and compatibility, and also administrated in an appropriate and safe manner – to ensure sustainable and safe usage.
Whilst its processing and uses are based on science, the process is dependent on generosity of doors, who offer most precious gift of all: life.
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- Introduction Every adult has around five litres of blood inside them, accounting for around 8% of their total body weight. Usage of donated blood by transfusion was a 20th century phenomenon and has become a long established therapeutic necessity. Around 2,000,000 units are transfused each year in UK, red cells remaining by far the most commonly transfused blood productL. There are many areas in which blood transfusions come useful – such as serious injuries, illnesses, operations, childbirth – and in the case of red cells, often in the case of severe anaemia and blood loss.... [tags: blood, donations, infection]
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