Fatal Dilemma: Using Clostridium botulinum as a Biological Weapon
Ever since the dawn of biotechnology, the world had to face a new dilemma: bioterrorism. Using biological agents such as bacteria, viruses, fungi, etc., bioterrorism attack aims to cause illness of death in people, animals, or plants as a method of warfare. Used throughout history, biological weapon serves as a pivotal role in disarming an army.
Botulism toxin, known for the most toxic substance in the biological world, has been used throughout history as a biological weapon. The bacteria Clostridium botulinum causes botulism causes botulism disease, which is a serious paralytic illness that strikes all age groups. The clinical forms of botulism include foodborne botulism, infant botulism, and wound botulism. Botulism, if left untreated, is fatal; however, even treatment with antiserum can not provide full recovery.
Botulism is rare a disease. Therefore, if anyone is diagnosed with foodborne botulism, investigation of food supply must be carried out promptly; for investigation of the botulism-diagnosed-individual's surrounding is the only method of detecting a potential bioterrorism attack.
With the continuous advancements in biomedicine follows a continuous proliferation of bioterrorism, which uses biological agents for malicious purposes (Anderson 2). More specifically, bioterrorism is a method of terrorism that intentionally releases or disseminates biological weapons that may be in natural occurring or human-modified form (Botulism- Definition). Although bioterrorism is considered as a recent dilemma, the use of biological weapon predates recorded history, during the ancient times where biological toxins were extracted from plants and animals and ap...
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Botulism is a neuroparalytic disorder characterized by the appearance of a descending flaccid paralysis produced by Clostridium botulinum toxin. The causal agent of this disease is a gram-positive anaerobic bacillus survives in soil and marine sediments through the formation of vegetative spores. Clostridium botulinum spores germinate favored by certain environmental conditions. The bacillus, during growth and autolysis releases a potent neurotoxin responsible for the symptoms of the disease. There are 7 types of toxin designated A through G. The toxin is absorbed from the intestinal tract and into systemic circulation to reach neuromuscular endings. At this level it binds to receptors on nerve endings
Food-borne botulism was the first form of the botulism toxin to be identified. It has a very high morbidity with prolonged intensive health care required for a full recovery (Taillac, & Kim, 2010). Also, people who have been infected with food-borne botulism can sometimes have muscle weakness or other similar issues for up to a year after the first onset of symptoms. Food-borne botulism is typically caused by improperly canned food. The symptoms of food-borne botulism include, but are not limited to: double vision...
Botulinum toxin has a complex chemical composition and is found in various surprising locations. The toxin is derived from Clostridium botulinum, and according to P.K. and Anjana Nigam, the authors of the Indian Journal of Dermatology, it is “an anaerobic, gram-positive, spore-forming rod commonly found on plants, in soil, water and the intestinal tracts of animals.” H. Bradford Hawley M.D., the editor of Magill’s Medical Guide, states that these bacteria are vastly immune to high temperatures and can persevere through numerous methods used to eradicate it and to get rid of toxins for secure consumption of food and water. Since the bacteria can be found in such a diverse variety of commodities, which all can be ingested by humans, it is critical to find a way to disinfect our soil, meat, and produce against C. botulinum.
Botulism is a rare but very serious paralytic illness that is caused by the botulinum toxin that is produced by the bacterium Clostridium botulinum. C. botulinum is a gram positive, anaerobic, spore forming bacterium that is naturally occurring in soil. Botulism dates back to the eighteenth century when the first food borne botulism was documented. During this time many people were doing home fermented sausages and this was thought to be the cause of botulism. This is how the toxin got its name since “Botulism” in Latin comes from “botulus” which means sausage. E. van Ermengen was the first to discover the microbe in 1897 after there was a food borne outbreak in Ellezelles, Belgium. To date there are six forms of botulism but only two forms were known until the twentieth century which were food borne and wound botulism. The first type of botulism is food borne which is a result of ingesting food that contains the pre-form toxin. Some foods that this typically occurs in are home canned vegetables, cured pork and ham and smoked or raw fish. Wound botulism is the result of C. botulinum spores growing in a contaminated wound with in vivo production. Most people that get wound botulism usually have deep and contained avascular areas and many people also had compound fractures. Wound botulism is on the rise in the U.S. because of the use of illicit drugs, “the majority were linked to injectable drug use, particularly with so-called ‘black tar heroin’ and others with nasal or sinus lesions due to chronic cocaine sniffing.” (CDC website) Another form of botulism is infant botulism. This is caused from the endogenous production of toxin germinating spores of C. botulinum in the intestines of the infants. Also feeding an infant...
Ryan, Jeffrey R., and Jan F. Glarum. Biosecurity & Bioterrorism: Containing and Preventing Biological Threats. Oxford: Elsevier Inc., 2008.
Clostridium botulinum has a rich history dating back to 19th century Europe where it first contaminated sausages, causing outbreaks of foodborne botulism. (1-3) In fact, the term botulism is derived from the Latin term botulus, meaning sausage. (1,3) Microbiologist Emile Pierre Marie van Ermengem first described the etiologic agent in 1897, (1-3) following isolation of the anaerobic bacillus from ham and splenic tissue obtained upon autopsy. (2,3) Although first referred to as Bacillus botulinus, it was eventually renamed Clostridium botulinum to distinguish it from the aerobic spore-forming genus Bacillus. (2) Importantly, the presence of a toxin was noted at this time, as cell-free extracts were capable of causing disease. (1,2) By 1943 and 1976, wound botulism and infant botulism were also respectively described. (1)
Roffey, R., et al. "Biological weapons and bioterrorism preparedness: importance of public‐health awareness and international cooperation." Clinical microbiology and infection 8.8 (2002): 522-528.
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It is also rather recent, only about a year and a half old. It’s not for profit, and is simply there to inform the public about botulism. The CDC is run by doctors and other lab specialists who have been doing extensive research in botulism as well as many other diseases, so they are well informed on the topic.
Merriam-Webster defines biological warfare as, "warfare involving the use of living organisms (as disease germs) or their toxic products as weapons."(2) From this definition, all pathogenic organisms are potential biological weapons. Anthrax, smallpox, plague, botulinum toxin, and tularemia all could be used. Bacteria used as biological weapons are those that are deadly, cheap, and able to infect many individuals through aerosols, or canisters that propel the bacteria into the air for th...
Since the beginning of civilization, poisons have been used for assassination purposes. The foundation of microbiology allowed those who were interested in biological weapons, to chose and design different biological agents. The potential dangers of these agents were soon recognized and resulted in two international declarations that prohibited the use of poisoned weapons. These treaties, however, contained no means of control and therefore, interested parties were developing and using biological weapons that we can see illustrated by the German army in the First World War. The German army was the first to use biological and chemical weapons, attempting to infect animals directly and to contaminate animal feed in their enemies’ co...
For one thing, they can last a very long time, continuing to spread throughout the target. Bullets can only be shot once, and bombs are finished after exploding, but biological agents multiply and continue to do so until a vaccine or other treatment is found. With some organisms, an epidemic could stem from just a few particles (Pytlak). A example of an extremely deadly toxin is Botulinum; a gram of it could kill over a million people if inhaled. Marburg virus, possibly even more dangerous, is a member of the filovirus family, which includes Ebola. It is a Category A bio-warfare agent according to the CDC’s classification system, which means it is among the most deadly bioweapons yet classified (Most Dangerous). Madeleine Albright, the first female Secretary of State, claims that “The risks that the leaders of a rogue state will use nuclear, chemical or biological weapons against us or our allies is the greatest threat we
Yersinia pestis (plague) is an example of bioterrorism. This disease has caused several deaths for the past 2,000 years in Europe and in Asia. In the 14th century it was called the Bubonic plague, better known as “the Black Death.”
Thesis: Biological Warfare is morally and inhumanely wrong, It is the wrongful killing of men, women, and children. It should be stopped no matter what the circumstances are.