Keywords: Multiwalled Carbon Nanotubes, 6-Mercaptopurine, Anticancer, Fusion Method.
Cancer is amongst the top three killers in modern society, next to heart and cerebrovascular diseases. Treating cancer has always been a challenge because cancer chemotherapeutic agents are cytotoxic and cannot differentiate cancer cells from normal cells. This leads to the destruction or impairment of vi...
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...ents like PEG to achieve long blood circulation half-life helping to impede in-vivo opsonization and reduced reticulo-endothelial system uptake. In addition, many oxygen containing groups, mainly carboxyl and hydroxyl, have been found to decorate the surface of CNTs oxidized with strong acids.
Several targeted anticancer delivery systems containing 6-Mercaptopurine (6MP) have been reported[14-18]. In the present study, 6MP (6, 7-dihydro-3H-purine-6-thione) (Fig 1) loaded CNTs were developed by slight modification in fusion method. Non-covalent functionalization of Multi walled Carbon Nanotubes (MWCNTs) was achieved using basic treatment followed by treatment with HCl. Functionalized MWCNT were attached with 6MP by sonication in a suitable media (pH 7.4). The formulations were characterized for drug entrapment, in vitro drug release and release kinetics.
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