Understansing Haemophilia Essay

Understansing Haemophilia Essay

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Introduction to Haemophilia

Haemophilia is a term that is used to describe a collection of hereditary blood disorders which has a lifetime defect in the clotting method of the blood. It is estimated that 1 in 5000 men have haemophilia. For a person without haemophilia, the clotting point act like a row of dominos against each other like a cause and effect reaction. When one of the factors is missing the clotting mechanism is not activated. Haemophilia A also known as factor VIII is the common defective seen in haemophilia. The less common form of haemophilia is haemophilia B also known as factor XI.

The same inheritance types and symptoms can be seen in haemophilia A and b. The method of differentiating between haemophilia A and haemophilia B is to carry out blood tests. In order to give the correct treatment, you need to find out which factor is the defective one and then any treatment procedures can begin. There have been very rare cases in which both haemophilia A and haemophilia B affect only males. Von-Willebrand's syndrome is a third condition and it is a mix of factor VIII with platelets that do not function properly which affects both males and females. In a person who has haemophilia, how severe the haemophilia is, dependant on the amount of clotting factors in the blood.

Prevalence of disease

There are two common forms of haemophilia which are much more common in males than females. Haemophilia A is more common than Haemophilia B. 1 in 4,000 to 1 in 5,000 males worldwide are born with haemophilia A. Approximately 1 in 20,000 newborn males worldwide have haemophilia B.


Symptoms of Haemophilia

For those severely affected, the major problem is the bleeding that happens in the joints, muscles and soft tissues. Dama...


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...ing HIV or hepatitis C from clotting factor. Pharmaceutical companies are also investigating genetically manufactured product alternatives which a derived from little to no human blood products. New products are constantly being made that have an increased purity than have ever been before.




References

• 1991. Introduction to haemophilia. The haemophilia society. Fourth Edition.Border Press (Shropshire) LTD.

• Haemophilia [ONLINE] Available at: http://umm.edu/health/medical/altmed/condition/hemophilia [Accessed at 20th December 2013]

• Haemophilia [ONLINE] Available at: http://www.sparkpeople.com/resource/health_a-z_detail.asp?AZ=227&Page=8 [Accessed at 20th December 2013]

• National Haemophilia Foundation: Future Therapies [ONLINE] Available at: http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=202&contentid=384 [Accessed at 20th December 2013]

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