This causes the stabilization of the compound. Diethyl ether or Tetrahydrofuran (THF) are the two commonly used ethereal solvents. Diethyl ether is used over tetrahydrofuran due to cost and the ability to be easily removed from the solution (1). Use caution when opening diethyl ether and tetrahydrofuran containers because they have the ability to create hydroperoxides, which are dangerous because they are explosives. Hydroperoxides
Salmeterol: The Optimization of an Asthmatic Drug Abstract: Asthma can be found in so many people all across world. Asthma is not biased; sex, race, or country does not matter. Asthma affects a large percent of the global population. Becoming aware of this is the first step. Now, using a drug in use, salmeterol, I want to optimize this drug to make it better by giving it different analogs, which will give it different properties. Using the latest technology in the Chemistry Lab, Gaussview
diastereomer-atorvastatin (DSAT), and other unknown impurities and formulation excipients of tablets can be obtained by adopting a simple HPLC method. The best resolution is obtained using a Luna C18 column with acetonitrile-ammonium acetate buffer and 4-tetrahydrofuran (THF) as mobile phase (Erturk at
Ishaan Sangwan Experiment 7: Grignard Reaction Discussion In this experiment, a Grignard reaction was performed to create a carbon-carbon bond, between a bromide and carbon dioxide. The product was then protonated to form a carboxylic acid, which was identified by obtaining its melting point, and by performing a titration with NaOH to obtain its molecular weight. In organometallic chemistry, carbon is bound to a metal. Usually, carbons are bound to elements that are more electronegative than carbon
The Chemical Synthesis of Oligonucleotides and the Phosphoramidite Method By Klaus D. Linse The study of nucleic acids has now become a fruitful and dynamic scientific enterprise. Nucleic acids are of unique importance in biological systems. Genes are made up of deoxyribonucleic acid or DNA, and each gene is a linear segment, or polymer, of a long DNA molecule. A DNA polymer, or DNA oligonucleotide, contains a linear arrangement of subunits called nucleotides. There are four types of nucleotides
Admiralty Outline Overview Admiralty is federal law, originating in Article III, § 2 of Constitution. i. First Congress included Cases of Admiralty/Maritime in Judiciary Act. ii. Supremacy Clause. b. If say that case is admiralty/maritime case, governed by admiralty law, is to say that substantive admiralty law applies. i. Differences: statute of limitations, comparative laws for recovery, etc. a. Main: trial by judge. From very beginning, admiralty cases are w/o juries. May