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    Prozac (Selective Serotonin Reuptake Inhibitors) Selective Serotonin Reuptake Inhibitors have been approved for use in the treatment of a wide area of psychological disorders, including major depression, obsessive-compulsive disorder, bulimia nervosa, panic disorder, social phobia, post traumatic stress disorder, and premenstrual dysphoric disorder. They are also said to be effective in treating dysthymia and chronic depression. (Tollefson and Rosenbaum, 2001) The manufacturer of Prozac

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    the various possible links between the function of neurotransmitters in the brain and mood disorders. The neurotransmitter serotonin, found widely in plants, animals and humans has been a particular focus. Scientists who specialize in examining the function and effect of serotonin on the mind and body argue that imbalances in the levels and function of serotonin can be linked to disturbances in mood, anxiety, satiety, cognition, aggression and sexual drives (Tollefson and Rosenbalum, 2001)

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    Part of the Neurons affected by SSRI Inhibitor/Prozac Pharmacological Effects SSRI selectively blocked the reuptake of 5HT through their inhibiting effects on the Na+/K+ adenosine triphosphatase (ATPase) dependant carrier in presynaptic neurons. A standard TCA such as amitriptyline, which has about an equal tendency to block neuronal reuptake of 5HT and norepinephrine, Fluoxetine in 200 times more selective in blocking the reuptake of 5HT than of norepinephrine. Florentine is approximately

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    Serotonin as an Antidepressant Until 1920, the action at a synapse was thought to be electrical. Otto Loewi, a German physiologist, aroused from sleep, with an idea to demonstrate the action at a synapse is chemical. He did so by taking fluid from one frogs' heart and transferred it to another frogs' heart to find that the heart rate increased. He also did this with another fluid, which decreased the heart rate. From this, he concluded that nerves send messages by releasing chemicals. These

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    SSRI

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    Citalopram Generic Name: Citalopram Brand name: Celexa, Cipramil INTRODUCTION Citalopram is one of the Selective serotonin reuptake inhibitors (SSRIs) which are prescribed mainly for depressive episode. INDICATIONS • Depression –FDA approved. • Premenstrual dysphoric disorder (PMDD) • Obsessive-compulsive disorder (OCD) • Panic disorder • Generalized anxiety disorder • Posttraumatic stress disorder (PTSD) • Social anxiety disorder (social phobia) DOSAGE AND ADMININSTRATION Dosage Forms Tablets

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    Prozac: Fluoxetine

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    1980s that a newer class of antidepressants revolutionized the treatment of depression. Selective serotonin reuptake inhibitors (SSRIs) were the first of these medications to be available in the United States. Fluoxetine (Prozac) was the first of its kind. (Kramlinger, 2001) Fluoxetine first appeared in scientific literature as Lilly 110410 (the hydrochloride form), a selective serotonin uptake inhibitor, in August 15, 1974 issue of, Life Sciences (Wong,... ... middle of paper ... ...el

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    Depression: Out of the Shadows

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    Everyone feels sad here and there, but for many people who experience depression those feelings can linger for years. Depression is a social disorder characterized by a depressed mood or a loss of interest or pleasure in daily activities, consistently for a 2 week period. “Depression is an under umbrella mood disorder that can cause people to feel hopeless, not have enough energy to get up and do things, it can affect people ability to live a day to day life , ranges from mild- severe

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    plasma membrane. Monoamine is carried in to the vesicles by the latter non-selectively and dopamine, nor adrenaline and serotonin is transported into vesicles by Na+/Cl- and selectively former. Monoamine transportation into the cytoplasm is inhibited when antiepileptic drugs for instance SSRI is attached to nor adrenaline transport (NET) or Dopamine transporter (DAT) and serotonin transport (SERT). Thus the monoamine level increases in the synaptic cleft. Monoamine transporters are the site for drug

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    the cerebral cortex, cerebellum and limbic system. Barbiturates have their own binding sites and modulate the chloride channel. They increase the duration of this channel, while benzodiazepines increase the frequency. Also barbiturates are less selective than benzodiazepines on the CNS. Barbiturates are positive allosteric modulation of GABAA receptors. These drugs bind to this receptor at the beta end, which are distinct from GABA and benzodiazepine binding sites as well as block the AMPA receptor

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    Project Research Topic Selective Serotonin Reuptake Inhibitors(SSRI’s) are a group of antidepressants that are theorized to aid in the treatment of many mental disorders including depression,anxiety disorders, obsessive compulsive disorder, post traumatic stress disorder, and eating disorders such as bulimia nervosa. True to their name, these medications increase the amount of serotonin in the gaps, or synapses, between the neurons by preventing the reuptake of serotonin between the neurons. With

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