function of retinoids. Retinoids are vitamin A derivatives. They help to regulate differentiation and cell proliferation. Higher expression of retinoid signaling takes place in neuronal plasticity areas such as the hippocampus, retrosplenial, and prefrontal cortex (2). Retinoid signaling in the brain helps to control the brain functions. These include neurotransmitter release, neuronal differentiation, neurite growth, and long term potentiation (3). Retinoids are mediated by nuclear receptors (4). These
The drug competitively inhibits the binding of androgens to androgen receptors [Katsambas]. Additional antiandrogenic effects of spironolactone may also include inhibition of enzymatic conversion of androstenedione to testosterone, inhibition of 5-alpha reductase, and increased steroid-hormone binding globulin [George]. The
Vitamin A contributes to several other important biological functions including nuclear transcription, skin cell differentiation, growth, and immunity. As animals are not capable of synthesis, vitamin A and its metabolites (collectively know as the retinoids) must be obtained through the diet (Goodman 1984). Two major forms of vitamin A are found in food: retinol and carotenoids. All of these fat-soluble vitamins contain two distinct structural features that contribute to all of their activity. The
Fasting upregulates PPARγ in adipocyte AMPK activated Adipose Structure and Function There are two categories of human adipose tissue, subcutaneous adipose tissue (SCAT) and visceral adipose tissue (VAT). Adipose tissue can be further classified as white adipose tissue (WAT) and brown adipose tissue (BAT). Adipose is composed of adipocytes, pre-adipocytes, fibroblasts, and immune cells. A vascular network runs through adipose while nerves innervate the tissue as well. Adipocytes found in WAT contain