Multiple Myeloma What is Multiple Myeloma? Multiple myeloma, also known as myeloma, hematologic cancer, or cancer of the blood is a plasma cell cancer, a type of white blood cell made in the bone marrow that is responsible for creating antibodies. A Multiple myeloma diagnosis means a group of these plasma cells has become cancerous and is multiplying. This cancerous multiplication of plasma cells raises the the level of abnormal proteins in circulating blood, and reduces the space available in the
embryogenesis. The following discussion paper will give a brief description of the multiple myeloma. It will then discuss about the history of thalidomide, its pathogenesis, usefulness and side effects on embryo and foetal development. Also, it will discuss about the factors affecting teratogenicity, diagnosis process to detect any defect on unborn baby and general recommendation to the patient. Multiple myeloma Multiple myeloma is a clonal disease characterised by neoplastic transformation, proliferation
in particular caught my attention, Daratumumab. This target therapy for Multiple Myeloma patients was still undergoing experimental trials at Mount Sinai and I saw how the Myeloma team took precautions with this drug. Kristen not only showed me the infusion center but also the OR. I indulged myself into the surgeon's work that at times I did not know what time it was, the time that I am supposed to leave for the day. The myeloma team showed me how the drugs given to patients affects the patient's body
patient presented in this paper is Ms. H an 83 year old African American woman that appears younger than stated age with a history of Multiple Myeloma. The patient chart was reviewed and an interview conducted. Interestingly the patient had retained every note, lab, hospital H&P and discharge summary in a file folder in her possession. Ms. H was diagnosed with Multiple Myeloma in April of 2008 when she was being worked up at her dentist for a toothache. X-rays performed revealed she had bone lesions in
ventilator and to everyone’s surprise was able to breathe but, a day later she could no longer do so and now she has been on life support for a year. (Lyman et al, 2011) Another patient that I took particular interest in was John Moloney a 53 year old multiple myeloma patient who has tried every form of treatment with no success. (Lyman et al, 2011) Despite trying everything he still wanted treatment so he could live and go home with his family but ended up in
A 73-year old female presented to St Vincents Emergency Department, with a 3 week history of progressive dyspnoea, cough, and lethargy, on a background of a 6-year history of Multiple Myeloma. Just prior to presentation, she had also developed a fever. In terms of her presenting complaint, she described herself as an active lady, who ran her own pub, but her recent symptoms rendered her unable to carry out her normal activities, such that her husband recommended she should go to hospital. Following
directly to its destination port. Switching increases network performance, enhances flexibility and eases moves, add-ons and changes. One of the benefits of switching is that it maintains a direct line of communication between two ports, and maintains multiple simultaneous links between various ports. It reduces network traffic by reducing media sharing. This technology has some benefits over ethernet routed networks. First, a 10 Mbps or 100 Mbps shared media can be changed to 10 Mbps or 100 Mbps of dedicated
Othello’s Themeland Built on a broad base of multiple themes, Othello is one of William Shakespeare’s most popular tragedies. Let’s sift through the themes and try to rank them in significance. In the Introduction to The Folger Library General Reader’s Shakespeare, Louis B. Wright and Virginia A. LaMar consider the arch-villainy of the ancient to be the most potent theme: Othello avoids all irrelevancies and the action moves swiftly from the first scene to the denouement. We
notion of the grouping of three is dominant..." (429). In the major details of the story, we find "three fantastic moments" (Slonimsky 429), three cards, three major catastrophes, three main characters, and the use of six chapters, six being a multiple of three. The three fantastic moments are: "the story of Tomsky (Chapter 1), the vision of Hermann (Chapter 5), and the miraculous win (Chapter 6)" (429). These three moments form the backbone of the story. In Tomsky's story, one first reads of the
Eliot's Use of Different Speakers in The Waste Land Different speakers in "The Waste Land" mirror the disjointedness of modern experience by presenting different viewpoints that the reader is forced to put together for himself. This is similar to the disassociation in modern life in that life has ceased to be a unified whole: various aspects of 20th-century life -- various academic disciplines, theory and practice, Church and State, and Eliot's "disassociation of sensibilities," or separation
completely nonlinear fashion that makes it very difficult to view as a good account of history; the jumping around that it goes through makes it very difficult to place oneself into the story. Due to this jumping around that the book proceeds through, multiple viewpoints are easily created which completely derail the reader from the actual truth of what really happened. In many cases, Beloved does not show sign of what a true history would entail, as understood in the articles and essays of many. It is
at these images. When the slide projectors give off that first glimmer of light, their Gatsby spot of a blurry green hope at the end of the dock, we depart on our collective imaginary field trips. The teacher doesn't need to coax, to pry, to pose multiple-choice questions. We are already on our way. I wander down the Hall of Mirrors in the French Palace of Versailles. Soon after I am thinking of the converse style, and recall that German Architect Mies van der Rohe has created the most simplistic
dealings with his father's eerie death cause Hamlet to grow up fast. His family, his sweetheart, and his school friends all appear to turn against him and to ally themselves with the evil predicament in which Hamlet finds himself. Hamlet makes multiple attempts to avenge his father's murder, but each fails because his father's murder, but each fails because his plans are marred by very human shortcomings. It is these shortcomings that Hamlet is a symbol of ordinary humanity and give him the
All I could see were lights flashing and shadows moving in all directions. The rolling bed that I was on stopped abruptly and a mask was placed over my face. I tried not to breathe, but in less than a second I was unconscious. In no apparent order multiple scenes began to flash through my head. My thoughts turned to nothing, and for one minute all I saw in my mind was an everlasting black hole accompanied by a single deafening beep. Suddenly, I awoke to the clanging sound of my alarm clock. I must
remainder was sold to Candler. Pemberton was forced to sell because he was in a state of poor health and was in debt. He had paid $76.96 for advertising, but he only made $50.00 in profits. Candler acquired the whole company for $2,300(Coca-Cola multiple pages). Candler achieved a lot during his time as owner of the company. On January 31, 1893, the famous Coca-Cola formula was patented. He also opened the first syrup manufacturing plant in 1884. His great achievement was large scale bottling
Neurodegenerative Diseases A piece of well-oiled machinery consists of an intricate and complex system: there are well-organized processes, mechanisms within the device work efficiently, and multiple processes function simultaneously to subsequently perform various functions. What happens when there is a glitch in the machine? When there is something wrong, such as connections between intricate processes, which do not follow through, the machine fails to function properly. In some cases, there
result of prompting individuals to prepare for certain events, such as exams and presentations, that clearly benefit from this action. Panic disorder is a type of anxiety disorder characterized by "brief episodes of intense fear accompanied by multiple physical symptoms (such as heart palpitations and dizziness) that occur repeatedly and unexpectedly in the absence of any external threat." Unlike fear, there is seemingly no reason or input that causes such an episode. It feels almost like an internal
the Family in White Noise Don Dellilo's protagonist in his novel "White Noise," Jack Gladney, has a "nuclear family" that is, ostensibly, a prime example of the disjointed nature way of the "family" of the 80's and 90's -- what with Jack's multiple past marriages and the fact that his children aren't all related. It's basically the antipodal image of the 1950's "nuclear family." Despite this surface-level disjointedness, it is his family and the "extrasensory rapport" that he shares with them
importantly, postmodernism looks upon the "modern" world with increased cynicism and disappointment. Key themes in postmodern thought include irony, arbitrary actions, intertexture, surface and superficiality, self-consciousness, skepticism, multiple perspectives, and relativism. In Anthony Minghella's film The English Patient, postmodernism is addressed using all of these themes in interrelated situations. The film uses irony as a primary mode of expression, subverting conventions
Language in Dante’s Inferno What happens to language in hell? In Dante’s Inferno, the journeying pilgrim explores language’s variations and nuances as he attempts to communicate with hell’s pitiable and sordid inhabitants, despite multiple language barriers and relentless cacophonies. Dante thematically unifies language’s inconsistencies in hell; that is, he associates the pilgrim’s abortive attempts to communicate with particular shades, and the incomprehensible languages and sounds that beleaguer