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    Amyotrophic Lateral Sclerosis

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    Amyotrophic Lateral Sclerosis ABSTRACT At this time, Amyotrophic Lateral Sclerosis(ALS) is a very confusing and elusive disorder. While the clinical presentation and diagnosis of ALS dates back to the early 1900’s, with Charcot being the first to scientifically report and document his findings, there simply has not been definitive evidence since that time for the etiology for ALS. This fundamental problem has befuddled the most qualified researchers and its ensuing answer has eluded the

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    Amyotrophic Lateral Sclerosis Motor Neuron Disease Maladie de Charcot Lou Gehrig's Disease What is the Disease? ALS is an extremely deadly disease affecting the nerve cells that control the victim's voluntary muscles. These nerves shrink and eventually die, leaving the muscles without stimulation. As these muscles go without stimulation, they too eventually shrink and die. The victim progressively weakens to the point of complete paralysis of all voluntary muscles and some involuntary muscles

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    Amyotrophic Lateral Sclerosis

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    Amyotrophic Lateral Sclerosis Have you ever had an experience of morning paralysis where you see yourself lying down, and you think you're awake so you try to get up, but suddenly you realize that you can't move? I have, several times. They have been the most frustrating and scariest times of my life. As I try harder to move, concentrating all my energy into moving one arm, the deeper I seem to be sinking in this indescribable feeling of entrapment. I hear the people outside my room and try

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    Amyotrophic Lateral Sclerosis

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    Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis is an insidiously developing, adult-onset, progressive anterior horn cell degeneration with associated degeneration of descending motor pathways. Despite increasing clinical and research interest, its cause remains obscure. Although many theories as to its cause have been proposed, no intervention has yet been shown to modify biologically determined motor system degeneration. There is no clear cut neuropathological diagnosis for

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    Amyotrophic Lateral Sclerosis

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    Part I: Amyotrophic Lateral Sclerosis (ALS) is an age-related disorder which results in rapid, selective deterioration of motor neurons of the central nervous system. ALS was first described by Jean-Martin Charcot in the 1870s and is the most common motor neuron disease, with an incidence of 2 per 100,000 people. It predominantly includes primary lateral sclerosis, a disease restricted to upper motor neurons and progressive muscular atrophy, which is limited to lower motor neurons. The onset

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    Amyotrophic Lateral Sclerosis

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    muscles. UMNs and LMNs are responsible for movements such as walking and chewing, and movement of the arms, legs, chest, and face, respectively. This permits healthy individuals the ability to voluntarily move their muscles with ease. Amyotrophic Lateral Sclerosis is also referred to as a motor neuron disorder (MND), as it is characterized by the continual degeneration of upper and lower motor neurons. These motor neurons, as previously stated, are responsible for voluntary muscles in the body, and

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    Amyotrophic Lateral Sclerosis

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    Amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease, is a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement. Jean-Marie Charcot was the first to recognize ALS as a distinct neurological disease with its own unique pathology. In ALS, nerve cells degenerate and deteriorate, and are unable to transmit messages to muscles. In around 90% of the cases of ALS, the cause remains unknown. Studies have concentrated on the responsibility of glutamate

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    Amyotrophic Lateral Sclerosis

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    twice, winner of a Triple Crown, holding the re... ... middle of paper ... ...urotoxic effects of TDP-32 overexpression in C. elegans. Human Molecular Genetics 19, 3206-3218 Chen, S., Sayana, P., Zhang, X., Le, W. (2013). Genetics of amyotrophic lateral sclerosis: and update. Molecular Neurodegeneration 8, 1-15 Lunn, J.S., Sakowski, S,A., Kim, B., Rosenberg, A.A., Feldman, E.L. (2009). Vascular endothelial growth factor prevents G93A-SOD1 induced motor neuron degeneration. Dev Neurobiology 69, 871-884

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    Amyotrophic Lateral Sclerosis

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    11727 Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis (ALS) is a disease that affects the nerve cells in the brain and spinal cord, specifically the motor neurons. Motor neurons carry signals from the brain and spinal cord to all of the muscles in your body. When a person has ALS, they are not able to generate enough motor neurons, and the brain cannot then initiate and control muscle movement. After some time, when the disease gets progressively worse, the patient has difficulty speaking

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    Amyotrophic Lateral Sclerosis

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    Amyotrophic Lateral Sclerosis (ALS) also known as Lou Gehrig’s disease is the most common form of motor neuron disease in the adulthood (Batos et al,. 2011). Motor neurons are cells that carry messages from the brain to the muscles so they can contract. During ALS these motor neurons gradually degenerate and die (Ingram, 2012). The symptoms progress from muscles weakness, clumsiness and cramping (Ingram, 2012). It can then start in the limbs, slowly eroding the ability to move, ending in paralysis

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