Molecular docking is a key tool in structural molecular biology and computer-assisted drug design. The goal of ligand—protein docking is to predict the predominant binding mode(s) of a ligand with a protein of known three-dimensional structure. Successful docking methods search high-dimensional spaces effectively and use a scoring function that correctly ranks candidate dockings. Garrett M. Morris and Marguerita Lim-Wilby, Molecular Docking, In Molecular Modeling of Proteins Methods in Molecular
To prepare for my media interview on tail docking, I researched multiple tail docking experiments from Penn State libraries` databases and the “Talking to the Media Guide handout. Looking back, I should have been more relaxed during my interview. I believe that it would`ve helped me in giving my responses faster and clearer. However, I made sure that I had my “management decision” terminology, Texel breed standards, and facts about tail-biting in pigs as the three areas that I could bridge back with
They use a strategy known as cross docking. Cross docking is the process of unloading materials from an incoming truck or trailer, then loading these materials directly onto outbound trucks, delivering the good directly to customers. This creates a remarkably proficient supply chain, of delivering
Argument Essay There has been a controversy about ear cropping and tail docking on dogs for quite some time now. Even though the procedures were done for good intentions at first, it has now turned into unnecessary surgeries done on animals, especially dogs. According to the Animal Legal and Historical Center, about 130,000 puppies go through an unnecessary cosmetic surgery in the United States each year. Ear cropping and tail docking both have their risks and should not be done to a dog for the sole
practice [of tail docking] entails cutting or crushing skin, bone, cartilage, muscle and nerves of the tail of a puppy less than a week old.” This common procedure began in ancient Rome. The surgery can be performed in two different ways. One way includes using a scalpel to surgically remove part of or the entire tail. The second way is to use a rubber rings (latex bands), which are tight around the tail and causes sloughing (to remove or shed dead skin) of the tail (“Cosmetic Tail Docking: an overview
increasing attention as anticancer agents. In vivo studies with NSAIDs have shown the anticancer property of these drugs against breast c... ... middle of paper ... ...han ArgusDock [14-15]. Conclusion Molecular docking was used to explore the binding mechanism and to correlate docking score of NSAIDs with the human estrogen alpha receptor (PDB ID: 3ERT) and estrogen related gamma receptor (PDB ID: 2GPU). In the present study, results show that NSAIDs have a good binding energy values with both
enthusiasts hope to see changed in the future. In the show ring, if a dog is found to have been cosmetically altered to mold it into the breed standard’s image, that dog is disqualified unless the surgeries in question are tail docking, or ear cropping. The reasons for cropping and docking are rooted in canine history, particularly in the history of fighting dogs, such as the Boxer, which once boasted “baiting” careers with bulls or bears.(Abraham 17) Cropped ears, while not only creating a fierce more threatening
consequences the procedure could have on the pup, there is no true reason as to why the cosmetic surgery should not take place besides a moral belief in letting the dog remain as it evolved to become. As stated by the American Kennel Club, “Tail docking… [is] performed shortly after birth, when the puppy’s nervous system is not fully developed. As a result, the puppy feels little to no pain, and there are no lasting negative health issues” (4). Yet despite these claims, there have been studies showing
Wal-Mart, now it is branded as Walmart is the world largest public multinational corporation by revenue in 2010, which runs a chain of large discount department stores and a chain of warehouse stores worldwide. Walmart focuses on the improvement of sales, constant reducing costs to offer goods at the best price, the adaptation of efficient distribution and logistics management systems to ensure the constant flow of the goods and the use of innovative IT and systems to accurate efficient operating
Animal cruelty is a continuing problem that grows each and every day. According to the United States Humane Society, animal cruelty can be either deliberate abuse or simply to the failure to take care of an animal. Cruelty does not just pertain to physical abuse; neglect is also a form of abuse. Animal neglect is not giving an animal necessary food, water, shelter, or vet care. To improve treatment and reduce the amount of abuse and neglect cases for animals is to enforce all cases to become
Wal-Mart, now it is branded as Walmart, is the world largest public multinational corporation by revenue in 2010, which runs a chain of large discount department stores and a chain of warehouse stores worldwide. Walmart focuses on the improvement of sales, constant reducing costs to offer goods at the best price, the adaptation of efficient distribution and logistics management systems to ensure the constant flow of the goods and the use of innovative IT and systems to accurate efficient operating
Dog Procedures There are many people in the world that hate the way something about them looks. So their way of changing that is to undergo a surgery to fix their imperfections. There are also many ways that you can do the same exact thing with a pet. With any pet there is always things that people might want to change for a health reason or a cosmetic reason. With these procedures there are many pros, but there are also many cons that come with it. There are many procedures that people can
doing some research work which we will be getting from research scholars and writing articles/papers are my responsibilities During my working period I have also submitted another research paper on “Insilico assessment of factor xa inhibitors by docking studies”which is under review.Iam planning plusing more papers which are under processs. I believe that i have all the qualities of a good researcher. I learnt many things from both my victories and failures.. I can accept both criticism and praise
Body Cameras are an important aspect of policing today, we need to implement them. Body Cameras haven’t been around that long, but are making a big impact on policing. In the United Kingdom in 2005, they began testing a body camera for police officers. In 2010, over 40 areas in the United Kingdom were using body cameras. In the United States, on August 9th, 2014 in Ferguson, Missouri, Michael Brown was shot by a police officer. On July 17th, 2014 in New York, Eric Garner died while in police custody
Pedigree Breeding is Unethical “The health problems affecting pedigree dogs are so extreme that a fifth of vets believe certain breeds should be banned altogether.” (Copping and Jasper). One of many such breeds is the pug. It is bred, as most dogs are, for appearance not health. Its squashed-face causes many problems for the dog. These pedigree dogs are also extremely expensive and sought after creating even more issues when new commercial breeders become involved in a potentially explosive
not possible with automobiles, as directly highlighted by Midgley (2011). As such, this meets the criteria of affordability, eco-friendliness and large coverage area. Thirdly, our bicycle rental system is automated and requires minimal manpower. Docking stations can be fully automated and rental and return is done through the use of ticketing machines (Midgley, 2011). Hence a bicycle sharing system eliminate the issue of poor management of staff since the reliance of manpower is
of the book’s release, many people were ignorant. This includes the pain that all animals, including horses, faced to please society (“How ‘Black Beauty’”). In addition, one of the other practices that Black Beauty placed a harsh light on was docking. Docking is when someone amputates the distal bony part of the limbs. This causes a horse’s tail to look shorter, solely for aesthetical purposes. This creates an issue because horses normally use their naturally long tails in order to get gnats and flies
Operational Planning for Wal-Mart Introduction The first Wal-Mart was opened in Rogers, Arkansas, in 1962. By 1969 it was incorporated into Wal-Mart Stores, Inc., and in 1972 went public on the New York Stock Exchange. The company grew steadily across the United States, and by 1990 was the nation's largest retailer. In 1991 and 1994, Wal-Mart moved into Mexico and Canada respectively. By 1997 it was incorporated into the Dow Jones Industrial Average. As of 2005, Wal-Mart has stores in the United
Wal-Mart is a world renown company that is famous for its low prices and huge selection of products and services. Wal-Mart is known as the one-stop shop where families can shop for groceries, clothes, house-hold appliances, and even car parts, all under one roof. It is also known for putting smaller, local stores out of business whenever they move to a new town, because these businesses cannot compete with Wal-Mart’s low prices. But how is Wal-Mart able to offer such low prices and still make a
back out doing so.” Not only is negligent docking disturbing the surrounding community, it is also becoming a safety hazard. Although there is a page dedicated to LimeBike describing expectations along with a video stating where bikes should be parked on the CSUN website, users are still not abiding by these rules. The root of this problem stems from the fact that there are no penalties against