Introduction- What is Etoricoxib? Etoricoxib, also known as Arcoxia1, is more commonly known as a non-steroidal anti-inflammatory drug (NSAID), or as a cyclo-oxygenase-2 inhibitor (COX-2). Therapeutically, it is specified for the ‘symptomatic relief” of conditions such as osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis2,3, and overall for their analgesic and anti-inflammatory properties. Arthritis is a chronic disease affecting up to ten million people in the UK. Approximately
Currently, she is taking Celebrex, (COX-2 inhibitor) which is a relatively new drug in the family of 'superaspirins'. What impressed... ... middle of paper ... ...ds the promise of an even greater understanding of pain in the coming years. Their research offers a powerful weapon in the battle to prolong and improve the lives of people with pain: hope (1) . References 1)National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/ 2)American Pain Society http://www
enzyme, Cyclo-Oxygenase (COX), which is involved in the first stage of prostaglandin production. There are two variants of this enzyme; COX-1 is responsible for the normal every day production of prostaglandins whereas COX-2 is responsible for production of additional prostaglandins when the body is injured as a natural defensive response. Non-selective NSAIDs, such as Ibuprofen, inhibit both COX-1 and COX-2 whereas selective NSAIDs; Celecoxib and Etoricoxib, inhibit only COX-2 (Society for Endocrinology
inhibition of apoptosis, stimulation of invasion and metastasis, and promotion of angiogenesis. While not much is known about ER beta, it is believed that its function is distinct from ER alpha and it probably has opposing activity on tumour growth [2]. Tamoxifen is the drug regularly prescribed for the treatment of breast cancer. The anticancer property of Tamoxifen has been attributed to its anti estrogenic properties. The use of Tamoxifen is limited due to the acquired Tamoxifen resistance in many
1.1 DRUG INTRODUCTION Antiplatelet drug are used to treat heart disease. They are powerful medications that prevent the formation of blood clots. When you are wounded, platelets arrive on the scene and group together, forming a blood clot that stops the bleeding. When an injury involves a break in your skin, this is a good thing. But platelets can also aggregate when injury to a blood vessel occurs from within the inside, as may happen in an artery affected by atherosclerosis. In this situation
collagen-induced arthritis (CIA) model. They found the GTPs administration would significantly reduce the incidence and lower the disease severity of arthritis, associated with a marked reduction in the expression of IFN-γ, TNF-α, and cyclooxygenase(COX)-2, as well as total IgG and type II collagen-specific IgG (Ab) in arthritic joints. Later on, the therapeutic effects of green tea or EGCG have been consistently reported in series of experiments using either CIA or Adjuvant-induced arthritis (AIA)
integral to the persistence of inflammation 6, 7. The term NF-B includes five structurally related and evolutionarily conserved rel proteins: RelA (p65), RelB, c-Rel (REL), NF-B1 (p50 and its precursor p105), and NF-B2 (p52 and its precursor p100) 2. In resting cells, NF- exists in the cytoplasm in several dimeric forms bound to I inhibitory proteins8. NF-B signaling can be activated via the canonical or alternative pathways. Activation of NF-B via the canonical pathway mediated by microbial
Therefore, Aceclofenac is an ideal candidate for sustained release formulation, resulting in more reproducible drug absorption and reducing the risk of local irritations.5 DRUG PROFILE (ACECLOFENAC) Category: Anti inflammatory drug Chemical name: 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy acetic acid. Chemical formula: C16H13C12NO4 Molecular weight: 354.18472 g/mol Structure: Indication: Aceclofenac 100mg Tablets are indicated for the relief of pain and inflammation in osteoarthritis,
Arthritis affects people of all age groups. More than 100 types of arthritis are known. Among these osteoarthritis and rheumatoid arthritis having the highest incidence. One of the major causes of chronic debilitation in industrialized nations is Osteoarthritis which results from damage to the joints, which may be due to trauma, infection, or age-related wear. Rheumatoid arthritis is encountered less frequently than osteoarthritis and is estimated to affect around one per cent of the world’s population
Manufacturers that sell dangerous medications can face government fines, as well as lawsuits from injured consumers. Experienced attorneys recognize that the only message these companies understand are ones that affect their pocketbook. The manufacturers of popular drugs all have had to pay the price for their dangerous actions at one time or another.]” Abilify is classified as a second- generation antipsychotic prescribed to treat bipolar disorder and schizophrenia. Unlike other drugs in its class
fruits are used for various diseases and disorders. Mangosteefn fruits benefits for health 1.Beauty and health. Mangosteen fruit contains antioxidants compounds, higher contents of vitamin E and C which are essential to maintain healthy life and beauty. 2. Good for preventing and treating Kidney stones. Generally men get affected by kidney stones than women. Mangosteen makes you urinate frequently thereby prevents formation kidney stones .Also by frequently urinating you can flush out the formed kidney
well. Merck a “research driven” pharmaceutical company “dedicated to putting patients first,” is one of the largest pharmaceutical companies throughout the world (Presley, 2). The American pharmaceutical giant manufactures, markets, research and develops a variety of health products worldwide. Vioxx, a selective COX-2 inhibitor drug designed to treat pain and inflammation, is one of such products that became the company’s bestselling-prescription painkiller; after the FDA approved the drug for treatment
acetaminophen was first described to be an analgesic and antypiretic [s17] and in 1948 paracetamol was found to be phenacetin’s and acetanilide’s metabolite which was responsible for the antipyretic and analgesic properties of these two compounds. [1] 2- Paracetamol is commonly used for acute musculoskeletal pains, acute headache, and fever[3][s03]. IV Acetaminophen can also be used with an opioid to improve overall analgesia in patients with postoperative pain. In addition, paracetamol can have an
2012). The primary factor in developing SLE is a genetic component although it is not fully understood (Robinson, Sheets Cook, & Currie, 2011). It has been shown that identical twins have a concordance rate of 24% whereas fraternal twins have a rate of 2% (“Systemic Lupus Erythematosus”, 2012). In addition, individuals have an 8-fold increased risk of developing SLE if they have a first-degree relative with the disease (Richman & Schub,
children in and adults, in children it is often linked to a genetic defect (Up-to-date, 2017). However, in adults MCD occurs as an idiopathic or secondary condition cause by an overuse of non-steroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors (Up-to-date, 2017). It is important for primary care providers to be aware of this MCD, so that
Arthritis As we grow older our bodies begin to degenerate, and stop working. There are many different kinds of diseases that we are subject to as we age, cancers, heart disease, Alzheimer’s disease, arthritis, and many others. All have a negative affect on our lives, making it difficult to function. Arthritis is the second leading chronic disease in the United States. Arthritis occurs when the body incorrectly identifies its own tissue as foreign matter and attacks it. Arthritis includes a
To function effectively in today’s society people must communicate with one another. Yet for some individuals communication experiences are so unrewarding that they either consciously or unconsciously avoid situations where communication is required. (McCroskey & Richmond, 1979) The term ‘communication apprehension’ was coined by James McCroskey (1976a) and is defined as “an individual’s level of fear or anxiety associated with either real or anticipated communication with another person or persons”
Product Anticancer Agents from Biodiverse Organisms." NIH Public Access 12.2 (2009): 189-96. 21. Davis, David A., Sarah H. Sarkar, Maha Hussain, Yiwei Li, and Fazlul H. Sarkar. "Increased Therapeutic Potential of an Experimental Anti-mitotic Inhibitor SB715992 by Genistein in PC-3 Human Prostate Cancer Cell Line." BMC Cancer 6.22 (2006): 1-9. 22. Chen, Dongfeng, Xubo Wu, Jiaxiang Wang, Baosan Han, Ping Zhu, and Chenghong Peng. "Morphological Observation of Interaction between PAMAM Dendrimer