There is immense study on the role of glutamate in Schizophrenia. Even so to date the current antipsychotics do not control major glutamatergic action albeit a study at the NMDA receptor location such as the glycine transport inhibitors may give new novel evidence for the discovery of future antipsychotics (Olney et al., 1999)
The Dopamine hypothesis of Schizophrenia
The dopamine (DA) theory of schizophrenia has subjugated the effort to justify the behaviours Schizophrenia is a psychiatric bedlam relating to the messing up of routine thinking, sentiment and every day activities. Egan & Weinberger (1979) described schizophrenia as when a subject or an individual is unable to differentiate what is genuine and unreal. The clinical characteristics of the various disarray of schizophrenia commonly come into view in the late adolescence or the early adulthood. Schizophrenia can exhibit either positive or negative or both signs. Whereas the positive sign is characterised by paranoia, false principles or hallucination, the negative aspect is marked by depression, withdrawal from communal connections. But pleasing of social responses shortfall in attention and memory are ascribed to cognitive effect. Generally, schizophrenia is considered to be neurodevelopment unrest rather than neurogenerative disorder (Harrison et al., 2003). There are several divisions in the brain that can be affected by schizophrenia. The atypical function of the basal ganglia is considered to play a role in paranoia and hallucination. The frontal lobe of the brain plays a role in problem solving and reasoning. Conversely a schizophrenic will have a deficiency in the lobe and as result, having difficulty in forecast and coordinating. Adjustment...
... middle of paper ...
...ts. Neuroscience, 90(3), 823-32.
Kim,J.S.,Kornhuber,H.H.,Schmid-Burgk,W.,Hlozmuller,B.(1980) Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neuorocience Letters 20:379-382
Kotter, H. (1994) Postsynaptic integration of gluamatergic and dopamine signals in the striatum. Progression in Neurobiology. 44:163-196
Olney, J. W., Newcomer, J. W., & Farber, B. B. (1999). NMDA receptor hypofunction model of schizophrenia. Journal of Psychiatric Research. 33: 523-533.
Stanley, J. A., Williamson, P. C., Drost, D. J., Carr, T. J., Rylett, R. J., Malla, A., Thompson R. T. (1996). An in vivo proton magnetic resonance spectroscopy study of schizophrenia patiens. Schizophrenia Bulletin, 22(4), 597-609.
Weinberger, D.A (1993) Connection approach to the prefrontal cortex. Journal of Neuropsychiatry. 5:241-253
Need Writing Help?
Get feedback on grammar, clarity, concision and logic instantly.Check your paper »
- Schizophrenia The medical definition for schizophrenia is a severe brain disorder in which people interpret reality abnormally. Schizophrenia may result in the combinations of hallucinations, delusions, and extremely disordered thinking and behavior. The word schizophrenia has not been around for long, it is actually less than 100 years old. This disease, however, was first discovered by a doctor named Emil Kraepelin in 1887. Before schizophrenia adopted its name, Kraepelin called this disease dementia praecox.... [tags: Schizophrenia, Psychosis, Mental disorder]
1621 words (4.6 pages)
- When thinking of someone with schizophrenia most people probably envision a person experiencing delusions and/or hallucinations. This may often be the case, but there are several diagnostic criteria to consider when assessing for schizophrenia. First, as most people envision a schizophrenic person, a person with schizophrenia will experience either delusions, hallucinations, or disorganized speech. They may in fact experience more than one or all of these criteria. Delusions are the false belief in something that is contraindicated.... [tags: Schizophrenia, Psychosis, Delusion, Catatonia]
828 words (2.4 pages)
- Elyn Saks said, “The schizophrenic mind is not so much split as shattered. I like to say schizophrenia is like a waking nightmare”. Schizophrenia is a long term mental disorder involving the breakdown between thought, behavior, and emotion. The title “Schizophrenia” is just an umbrella that encompasses more than one type of schizophrenia; such as Paranoid Schizophrenia, Disorganized Schizophrenia, Catatonic Schizophrenia, Residual Schizophrenia, and Schizoaffective Disorder (Mental Health America).... [tags: Schizophrenia, Psychosis]
1066 words (3 pages)
- People with schizophrenia experience unusual perceptions, odd thoughts, disturbed emotions, and motor abnormalities. Also, they experience psychosis, which is a loss of contact with reality. Schizophrenia can make it difficult for people to function at home, with friends, in school, or at work because their ability to perceive and respond to the environment becomes extremely disturbed. They might have hallucinations or delusions, or they might withdraw into a private world. About 1 of every 100 people in the world deal with schizophrenia during his or her lifetime and an estimated 24 million people worldwide are suffering with this disorder, with 2.5 million of these people in the United Sta... [tags: Schizophrenia, Psychosis, Catatonia, Delusion]
1055 words (3 pages)
- Throughout life there are many challenges that are presented when trying to figure out what type of life is best suited for the individual. Many realise this when moving out from the house of the parents and into the world. However, this task can be made more difficult when living with a mental disability. This paper will examine what it is like to live with schizophrenia. From the obstacles the individual must overcome to who else it affects, such as, the role of the family and friends. There are many moving parts that play a role in the standard of living for an individual with schizophrenia and if they do not all function well together, that can cause a great disadvantage for those affect... [tags: Schizophrenia, Mental disorder, Anxiety disorder]
1107 words (3.2 pages)
- Schizophrenia is a mental disorder that affects about one percent of the population. Generally if you have schizophrenia you cut out of contact with real world reality. The word Schizophrenia is Greek for “split mind”. It is common belief that a person with schizophrenia or a “schizo” has a split personality, but actually the person’s thinking, feelings, and behavior are so far from normal that they get to the point where they interfere with their ability to function in everyday life. People who are suffering from schizophrenia think and act in their own world, which sets them apart from the society around them.... [tags: Schizophrenia Essays]
1019 words (2.9 pages)
- A man chooses to stay home from work for a day, not because he is sick, but just because. He starts to eat breakfast and decides to watch TV. He finds a TV show that shows a man going to work and his duties throughout the day. The second day the man decides not to go to work again and he watches the same program. The only difference is that today he recognizes that the man on the TV program is himself. He is watching his own day at work. The TV self is more ambitious, more of everything. The home self continues day after day, watching his TV self.... [tags: Schizophrenia Essays]
1446 words (4.1 pages)
- Schizophrenia is a serious, chronic mental disorder characterized by loss of contact with reality and disturbances of thought, mood, and perception. Schizophrenia is the most common and the most potentially sever and disabling of the psychosis, a term encompassing several severe mental disorders that result in the loss of contact with reality along with major personality derangements. Schizophrenia patients experience delusions, hallucinations and often lose thought process. Schizophrenia affects an estimated one percent of the population in every country of the world.... [tags: Schizophrenia Essays]
1137 words (3.2 pages)
- Schizophrenia is a mental disorder that Encarta (2001) describes as an illness that results in delusional thought patterns, hallucinations, and inappropriate effect. It literally means “split-mind’, but is not a multiple personality disorder. According to DSM-IV (1996) schizophrenia is categorized under the diagnostic code, ICD-9-CM or International Classification of Diseases, Ninth Revision, Clinical Modification of 295.xx. Symptoms of schizophrenia can be positive, which occur during the active phase, and negative, which are present before the onset of the disorder.... [tags: Schizophrenia Essays]
2305 words (6.6 pages)
- Schizophrenia is not a single disease, but a broad category of mental illnesses. Schizophrenia is a psychiatry disorder where several structural disturbances occur in the brain. It normally takes place in the temporal and frontal lobes, changing the neural systems and affecting the neurotransmitters in charge of controlling the functioning that takes place in these areas. It is not a structural brain disease that shows up early on X-rays CAT scans, or EEGs. Schizophrenics also have defects in the handling of amino acids.... [tags: Schizophrenics Psychiatry Disorder]
427 words (1.2 pages)