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Eassy about human genetics
Germline gene therapy essay
Human genetics essay
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The Relative Positives and Negatives Behind the Techniques and Outcomes of Germ-line Gene Therapy
Abstract:
Ever since the idea of altering the human genome was created through the research of germ-line gene therapy, advocates and protestors entered into contention with one another. Supporters of the new technology argue about the benefits of germ-line therapy. Humans have the right to scientific inquiry, especially if it is beneficial to mankind. However, their counterparts claim that the difficulty and unknown side effects (coupled with a few unsuccessful and fatal trials) will cause damage greater than any potential good. Furthermore, some even argue with the ethical issues resultant of a possible eugenics movement. Despite level of intellect or personal opinion about the issue, the new, viable chance for germ-line genetic therapy has quickly become a major issue of controversy.
Since the dawn of time, man has striven to postpone death while increasing his quality of life. In 1991, human medicine opened an entire new horizon when Ashanti DeSilva became the first person in the world to receive gene therapy for her illness (Gene Therapy Turns 10, 2001). Doctors managed to add a critical gene that allowed her to produce the then absent (and essential) adenosine deaminase (ADA) enzyme. However, because only somatic cells are effected, this practice only has partial success, as DeSilva still needs to take weekly injections of the DNA. Thus, the idea of germ-line gene therapy was born. Germ-line therapy, the altering of embryonic and sex cells of the body, allows all of the new cells in the body to contain DNA along with all future offspring produced by that individual. With the notion that germ-line altering could soon become a...
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... Human Gene Therapy, (volume 5). 151-152.
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Willgoos, Christine. (2001). FDA regulation: an answer to the questions of human cloning and germline gene therapy. American Journal of Law & Medicine, (volume 27), page 101.
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Germline gene therapy is where the correct "good" gene is inserted into the germline in place of the defective "bad" gene, and when reproduction occurs the gene will be passed on to the progeny. Inserting the "good" gene into the very early embryo sta ges of development allows for both germline and somatic cells to be corrected. Government has limited the research to only somatic cell gene therapy such as performed in Cystic Fibrosis research.
... fight the disease. It is crucial that regulation be a necessary component of gene therapy research and applications. In hopes that the government can regulate and can receive this treatment, not restricting it to people that has serious genetic diseases. Gene therapy will change the field of medicine from what it is today. As scientist discovers more genes and their functions, the potential of this treatment is limitless. Though gene therapy is an auspicious treatment choice for numerous diseases (including inherited disorders, some types of cancer, and certain viral infections), the procedure remains precarious and is still under study to make sure that it will be safe and effective. Thus government regulators and scientist must take a lead role in adopting a practical approach to address these issues and determining the correct procedures for dealing with them.
In the modern world humans have been able to design and create nearly anything, most to aid us in our daily lives and improve our standard of living. It is only inevitable that eventually humans would take our superior knowledge and skill to manipulate life itself and change our genome to produce a healthier and even more superior human standard of life. In recent years discussion about gene therapy has changed into a promising possibility to treat many of our common human diseases and disorders. Although gene therapy might be the answer to many problems, it has been met with a number of logistical and ethical hardships. With the prospect of being a treatment for inherited genetic disorders, cancers, and viral infections, gene therapy seems like the logical fix-it-all bandage that many people would benefit from.
Gene therapy is a technique which has developed in the wake of recombinant DNA (rDNA) technology. It is a process which results in the correction of a genetic disorder by the addition of a piece or fragment of DNA into the genetic material of a living, functioning cell. A mere thirty years ago this concept belonged to the realm of the human imagination made manifest in the works of science fiction. Today it belongs to the realm of the human imagination made manifest in the works of science, period. It is mind boggling to try to comprehend the far reaching effects of gene therapy. How is it affecting society? Who will benefit from its use? Should it be used at all? Should research continue? How do we answer all of these questions? The answers are not readily available, nor are they black and white, but an attempt at finding some solutions must be made. Before exploring this line of thought further, a basic understanding of the technical aspects of gene therapy is essential.
Despite being magical of gene therapy, it is high-risk. Few people got benefits from it, and it has a low rate of success. Prior to the human trial, Batshaw and Wilson had done experiment on animals to ensure the safety. Over 20 experiments have been done on mice but only 12 of them survived at last (Sophia, M. and Kolehmainen, J.D., 2000). More seriously, complicating diseases, which can be more dangerous than genetic diseases, might set in during the treatment period. In December 200...
What is more, we are now seeing gene therapy treatment getting closer to commercialization. Approval of the first gene therapy treatment in either the US or Europe occurred in November 2012 when the European Commission endorsed the recommendation of the European Medicines Agency to approve Glybera, a gene therapy, which address lipoprotein lipase deficiency which is the cause of severe pancreatitis (Richards).
"What's the worst that can happen to me? I die, and it's for the babies," said Jessie Gelsinger as he left for the hospital to receive gene therapy treatment. (Stolberg) People risk their lives everyday in the name of science. One such science that people have recently been drawn to is gene therapy. Although, gene therapy may be new and exciting and it may be helping to find cures to diseases we only dreamed of curing, we have to remember it is dangerous. It needs to be done with much supervision. Every new step we take in the advancement of gene therapy should be thought over because the consequences could reach farther then we ever believed they could. There are so many dangers of the techniques used that can lead to consequences as serious as death. The government imposes many guidelines, and it needs to stay that way. The biggest dangers, however, may be in what is to come.
People should not have access to genetically altering their children because of people’s views on God and their faith, the ethics involving humans, and the possible dangers in tampering with human genes. Although it is many parent’s dream to have the perfect child, or to create a child just the way they want, parents need to realize the reality in genetic engineering. Sometimes a dream should stay a figment of one’s imagination, so reality can go in without the chance of harming an innocent child’s life.
[7] Stock, G., and Campbell, J.. "Engineering the Human Germline: an Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children, New York; Oxford University Press, 2000. back
In today’s world, people are learning a great deal in the rapidly growing and developing fields of science and technology. Almost every day, an individual can see or hear about new discoveries and advances in these fields of study. One science that is rapidly progressing is genetic testing; a valuable science that promotes prevention efforts for genetically susceptible people and provides new strategies for disease management. Unnaturally, and morally wrong, genetic testing is a controversial science that manipulates human ethics. Although genetic testing has enormous advantages, the uncertainties of genetic testing will depreciate our quality of life, and thereby result in psychological burden, discrimination, and abortion.
High profile adverse events resulting in disproportionate media attention have prevented a greater difficulty for the field, with the death of Jesse Gelsinger in a trial of gene therapy for ornithine transcarbamylase deficiency undermining public trust of clinical research in the US. There is a danger that the gene therapy field may have become too risk-averse in response to these adverse events, and that this could manifest as fewer trials that take longer to commence. In the context of a research environment that is increasingly turning to the developing world for the expedient conduct of clinical trials, it is imper...
1) Robertson, John A. “Human Cloning and the Challenge of Regulation,” The New England Journal of Medicine, vol. 339, no. 2 (July 9, 1998), pp. 119-122.
Human genetic engineering can provide humanity with the capability to construct “designer babies” as well as cure multiple hereditary diseases. This can be accomplished by changing a human’s genotype to produce a desired phenotype. The outcome could cure both birth defects and hereditary diseases such as cancer and AIDS. Human genetic engineering can also allow mankind to permanently remove a mutated gene through embryo screening as well as allow parents to choose the desired traits for their children. Negative outcomes of this technology may include the transmission of harmful diseases and the production of genetic mutations. The benefits of human genetic engineering outweigh the risks by providing mankind with cures to multiple deadly diseases.
Bergeson, E. (1997) The Ethics of Gene Therapy [Online] Available at: http://www.ndsu.edu/pubweb/~mcclean/plsc431/students/bergeson.htm [Accessed 14 July 2011]
There are different ways and reasons why people wish to change the genes in their cells; the two categories split into “somatic and germline genetic engineering”. When a scientist uses “somatic genetic engineering” -the sex cells-- eggs and sperms are not affected; a specific gene code is changed and the genes do not pass down to the next generation. The other genetic engineering used is “germline” which, in contrast to somatic engineering, affects the eggs and sperms. When germline genetic engineering is used, the genes will be passed down to the next generation, affecting the physical and genetic traits. The debate rises and people question people’s free will. Bioethics is the formal and recognized term that describes the advantages and disadvantages that genetic enginee...