Systematic Lupus Erythematosus (SLE) is a very serious and mysterious disease affecting the immune system. The immune system is designed to protect against foreign substances such as viruses, bacteria, and germs that have infiltrated the body. The immune system has an innate component and an adaptive ability that allows it to produce cells specially designed to destroy foreign or “non-self” substances. The adaptive immune system has two main cells, B cells and T cells. There are different types of T cells, cytotoxic, helper, regulatory, and natural killer T cells. Normally the B cells produce antibodies that protect the body from invaders. The antibodies recognize a protein on a foreign target and bind to them, either marking an infected cell for attack by other parts of the immune system, or it can neutralize the target directly. Usually antibodies are quite good at differentiating between cells that are foreign or self.
Lupus causes the body to produce antibodies that attack the self or autoantibodies. The exact reason this happens is still not known. One possible cause is over-exposure to UV light, especially UVB. UV light induces the apoptosis of human keratinocytes, leading to the formation of clusters which contain both nuclear and cytoplasmic antigens on the surface of dying cells, providing a mechanism for the exposure of self antigens to the immune system and provoke autoimmunity(Mok, Lau 2003). The autoantibodies attack all kinds of cells and other self-components such as phospholipids and coagulation proteins (McCance 2010). The autoantibodies most commonly attack nucleic acids, histones, ribonucleoproteins, and other nuclear material (McCance 2010). T cell function is altered towards B cell help causing enhanced ...
... middle of paper ...
...us Foundation of America. (n.d.). Retrieved from http://www.lupus.org/
McCance, K. L., & Huether, S. E. (2010). Pathophysiology: The biologic basis for disease in adults and children. Maryland Heights, Mo: Mosby Elsevier.
Mok, , C. C., & Lau , C. S. (2003). Pathogenesis of systemic lupus erythematosus. Journal of Clinical Pathology, (56), 481–490.
Mosca , M., Ruiz-Irastorza, G., Khamashta, M. A., & Hughes, G. R. (2001). Treatment of systemic lupus erythematosus. International Immunopharmacology, 1(6), 1065–1075.
University of Florida: Details. (n.d.). Retrieved from http://tools.niehs.nih.gov/srp/Programs/ProgressReports.cfm?Project_ID=P42ES73750008&nOrder=2
Wallace, D. J. (1995). The lupus book. New York: Oxford University Press.
What is the Lupus "butterfly" rash? (n.d.). Retrieved from https://www.healthtap.com/user_questions/32706-what-is-the-lupus-butterfly-rash
Need Writing Help?
Get feedback on grammar, clarity, concision and logic instantly.Check your paper »
- Lupus has no precise meaning when used alone due to the various types, but it is a broad term for a chronic, progressive, skin disease. The types of lupus include: Lupus nephritis, Cutaneous lupus erythematosus, neuropsychiatric lupus, discoid lupus erythematosus, lupus pernio, lupus vulgaris, drug induced lupus erythematosus, and the most crucial systematic lupus erythematosus. The immune system is designated to attack foreign substances, but with lupus the immune system accidently attacks healthy cells and tissues damaging many parts of the body including: joints, the skin, kidneys, lungs, the heart, blood vessels, and the brain.... [tags: Nursing Essays]
1501 words (4.3 pages)
- Lupus (systemic lupus erythematosus) is an autoimmune condition that is characterized by systematic damages caused on the immune system by the body itself. The most affected parts if the body by this condition are, heart, kidney, liver, joints, and the brain. With these parts of the body affected, the entire body can end up being paralyzed or rather not working well. Lupus or SLE is commonly recognized by butterfly rush which spreads across the nose and cheeks (Magro et al. 2013). However, the most common symptoms for lupus are joint pains and swellings, kidney failures, fatigue, and photosensitivity.... [tags: illnesses that affect the immune system]
1275 words (3.6 pages)
- Lupus is a disease in a person body that mistake some of the body’s own tissues for invaders trying to harm the body host, so the body take it cautionary and attacks the tissues. It is considered an autoimmune disease. There are different types of Lupus; the most common one is Systemic Lupus Erythematosus (SLE) which is most common and serious type. Other types such as Cutaneous Lupus Erythematosus aka Discoid Lupus is limited to skin and doesn’t cause the organ damage that happens with SLE. Systemic Lupus Erythematosus while being a visual disease it also has some internal problems.... [tags: Systemic lupus erythematosus, Immune system]
1632 words (4.7 pages)
- Cutaneous lupus erythematosus (CLE) is an autoimmune disorder which effects the skin. Although it can affect people at any age, women in their late thirties to early forties are the most commonly effected (Heuther & McCance, 2012). It is not to be confused with systemic lupus erythematosus (SLE). Systemic lupus erythematosus effects the entire body and the body systems. However, in 75% of patients with SLE, CLE is also present (Obermoser, Sontheimer, and Zelger, 2010). It is important to monitor patients with CLE for signs of SLE using annual blood tests and other health screens (Chang & Werth, 2011).... [tags: Immune system, Lupus erythematosus]
1462 words (4.2 pages)
- Definition of Systemic Lupus Erythematosus Systemic Lupus Erythematosus is a chronic autoimmune disease. The body makes autoantibodies and initiates the immune response against itself. There is no known cause or origin. It is seven times more common in females than males. 20 percent of all lupus cases are diagnosed in childhood prior to age 16. (Ball, Bindler, & Cowen, 2015, p. 631) There is a suspicion that there is a genetic factor that causes a person to be predisposed to having Lupus. There is also a belief that it may be caused by an environmental factor that causes the immune system to respond to its own tissues, such as Epstein Barr.... [tags: Systemic lupus erythematosus, Immune system]
722 words (2.1 pages)
- Most know Systemic Lupus Erythematous (SLE) as simply lupus. Many may not realize the extent to which a person with SLE is affected on a day to day basis. It is important for healthcare professionals to understand the disease process, including the cause, signs, symptoms, and treatment of SLE. By understanding the aforementioned, healthcare professionals can assist with reporting signs and symptoms to the patient’s doctor to further reach a correct diagnosis. It is not only important to understand SLE to reach a diagnosis, but to provide holistic care to the patient.... [tags: rheumatrex, lupus, lymphadenopathy]
1703 words (4.9 pages)
- Lupus is an autoimmune disorder, which the body’s immune systems attack its own tissues and organs that results in inflammation and damage. (Ringold, Lynm & Glass, 2005). Antibodies in humans’ immune system fight infectious agents including bacteria, viruses, and other foreign microbes. People who have lupus produce abnormal antibodies in their blood that target tissues within their own body instead of the foreign infectious agents. There are several types of lupus including systemic lupus erythematous (SLE), discoid lupus erythematous, subacute cutaneous lupus erythematous, drug-induced lupus, and neonatal lupus.... [tags: Systemic lupus erythematosus, Immune system]
999 words (2.9 pages)
- It has been estimated that 1.5 million Americans, and millions more worldwide, have lupus. Most are diagnosed as young women of childbearing age who suffer from such symptoms as intense fatigue and exhaustion, joint pains, thinking and memory problems, and skin rashes. Men, children, and older women get lupus too (About Lupus, n.d.). In this paper in will explain the definition of Lupus, I will also give you the symptoms, causes, treatments, and diagnosis of someone with this disease. Keywords: [Click here to add keywords.] Systemic Lupus Erythematosus Lupus is an autoimmune disease characterized by acute and chronic inflammation of various tissues of the body.... [tags: Systemic lupus erythematosus, Immune system]
902 words (2.6 pages)
- Lupus is an autoimmune disease where the body's immune system becomes hyperactive and attacks normal, healthy tissue. Under normal function, the immune system makes proteins called antibodies in order to protect and fight against antigens such as viruses and bacteria. Lupus makes the immune system unable to differentiate between antigens and healthy tissue. This leads the immune system to direct antibodies against the healthy tissue - not just antigens - causing swelling, pain, and tissue damage.... [tags: autoimmune diseases]
1009 words (2.9 pages)
- One kind of autoimmune disease can damage any part of the body and sometimes out of control is known as lupus. People that will most likely be susceptible to lupus are women between ages ten to fifty, and lean towards Asians and African Americans. There are three main types of lupus. Discoid lupus erythematosus occurs when there are red rashes and mainly affects the skin. Drug-induced lupus can be initiated from a limited amount of medicine that only lasts as long as they are used. The last and most common form of lupus is systemic lupus erythematosus or also called SLE.... [tags: Medicine]
1259 words (3.6 pages)