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...ter vaccination. The more sensitive purified glycoprotein ELISA (gpELISA) or fluorescent antibody to membrane antigen (FAMA) tests have been used in research settings to detect seroconversion after vaccination.” (Clinical Overview, 2016). Another way to test for the specimens is the IgG avidity, IgG avidity has been used in research settings to determine if a person who is IgG positive for VZV was infected with the virus in the past or more recently. Avidity testing can be used to determine if the most recent VZV rash was due to primary infection (varicella) or reactivation (herpes zoster). People infected in the past tend to have antibodies with high affinity for binding to the antigen compared with people with a more recent infection who have a low affinity. As a result, low avidity is an indicator for VZV primary infection (Clinical Overview, 2016).
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