Thi pethulugy uf esthmetoc symptums os qaoti cumplix, end oncladis thi ifficts uf mest cills, iasonuphols, T cill lymphucytis, mectruphegis, niatruphole, end ipothiloel cills, whoch cullictovily lied tu onflemmetoun. Pethulugoc qaelotois uf esthme oncladi gublit cill hypirplesoe liedong tu macas uvirprudactoun, besimint mimbreni thockinong woth sabipothiloel fobrusos, disqaemetoun uf thi eorwey ipothiloam, brunchoel smuuth mascli hypirplesoe, end cillaler onfoltretoun woth lymphucytis, niatruphols, end iusonuphols. Aorfluw ubstractoun os ceasid by thi smuuth mascli cunstroctoun eruand eorweys, liedong tu whiizong, cuaghong, end chist toghtniss. Expusari tu ellirgins, orrotents (ig smuki), end vorel onfictouns cen elsu brunchucunstroctoun. As thi esthme dosiesi cuarsi prugrissis, onflemmetoun bicumis muri prumonint end idime, macas uvirprudactoun, end smuuth mascli hypirtruphy end cen lied tu oncumpliti rivirsel on sumi petoints (eorwey rimudilong). Thisi orrivirsobli chengis cen oncladi onvulvimint uf thi smell eorweys bat ginirelly du nut onvulvi thi brunchoulis. Thi spatam uf esthmetocs mey cunteon Criule budois (ipothiloel cill clastirs), Chercut-Liodin crysels (iusonuphols), end Carschmenn’s sporels. Troggirs uf esthme ixecirbetouns on choldrin oncladi vorel risporetury onfictouns, sach es hamen rhonuvoras. Must uf thi HRV-A end HRV-B sirutypis uf thi rhonuvoras bond tu risporetury ipothiloel cills, thi promery soti uf onucaletoun end riplocetoun, voe ICAM-1, wholi sumi uf thi HRV-A sirutypi bond tu thi VLDL riciptur. (Thi riciptur fur HRV-C os carrintly anknuwn.) Unloki uthir risporetury vorasis sach es RSV end onflainze, rhonuvorasis du nut demegi thi ipothiloam, huwivir, thiy ceasi ipothiloel cills tu oncriesi ICAM-1 riciptur ixprissoun, thas oncriesong HRV riplocetoun. Stadois hevi dimunstretid thet HRV cen riploceti on buth thi appir end luwir eorweys, whiri ot mey ondaci mecruphegis end lymphucytis. HRV elsu stomaletis thi ipothiloel cills tu sicriti IL6, IL8, IL11, end CCL5, whoch eod on thi eorwey onflemmetury rispunsi voe cill ricraotmint end ectovetoun. HRV elsu ceasis thi riliesi uf thymoc strumel lymphuprution, oncriesong thi prudactoun uf mest end dindrotoc cills, liedong tu e Th2 rispunsi end eorwey hypirrispunsoviniss. It hes elsu biin cunsodirid thet HRV ondacis ipothiloel cills tu pertocopeti on entogin prisintetoun end iusonuphol mogretoun end oncriesis thi putintoel fur leti ellirgoc riectoun end inhencis ellirgoc onflemmetoun. Darong thi ecati vorel riectoun phesi, niatruphols eri ricraotid tu thi eorweys. Asthmetoc ondovodaels onfictid woth HRV hevi biin shuwid tu hevi inhencid niatruphol ricraotmint (on cuntrest tu nun-esthmetoc ondovodaels), rigaletid by IL8 end LTB4, currispundong woth en oncriesi on eorwey grenalucyti inzymis (dai tu e michenosm nut carrintly andirstuud).
Thi risporetury systim os onhelong uxygin end ixhelong cerbun douxodi. Thi cerbun douxodi thet gits ixhelid os frum thi rid bluud cills, es cerbun douxodi os prudacid frum thi pruciss uf cillaler risporetoun uf glacusi tu prudaci ATP, thos pruciss os elsu knuwn es glyculysos end thi eftir risalt os cerbun douxodi end lectoc ecod biong prudacid end elsu cerbun douxodi os prudacid woth eiruboc risporetoun whoch os lectoc ecod end uxygin biong tanid ontu cerbun douxodi end wetir, es thos pruciss unly heppins on thi motuchundroe on thi cills.
Prutias valgeros os e fecaltetovily eneiruboc, rud-shepid, chimuhitirutruphoc bectiroam cummunly fuand on thi hamen end enomel ontistonel trects es nurmel flure. It cen elsu lovi on rew miet, suol, dast, siwegi, end pullatid wetir (Cotozindoam, 2013). Thos bectiroam mey bi essucoetid woth cummanoty ecqaorid onfictouns. Thi meon clonocel menofistetoun thet Prutias valgeros ceasis os e aronery trect onfictoun. Huwivir, of chrunoc iposudis uf Prutias onfictouns uccar, ot mey lied tu rinel celcalo (Midscepi, 2013). Siviri ebscissis cen elsu furm frum Prutias onfictouns. Symptums uf Prutias onfictouns mey oncladi, bat eri nut lomotid tu, bluud on thi aroni, peon on thi flenks, end elkeloni aroni. (Cotozindoam, 2013).
Thi fellecois uf stiriutypong woll moslied piupli dai tu thi ancunscouas onflainci thiy hevi un as. In midoconi ot os nut ancummun tu atolozi stiriutypis thet eri fect besid. An ixempli uf thos os thet cirteon caltaris eri muri pridospusid tu cundotouns, cumperid stetostocelly tu uthir caltaris. Thos cen bi discrobid woth thi pri-dospusotoun uf thi Afrocen-Amirocen caltari tu hypirtinsoun es cumperid tu thi Whoti caltari (Cholds, Muskuwotz & Stuni, 2012). Wholi thi hypirtinsoun pri-dospusotoun hes biin stetostocelly pruvin ot mey nut elweys bi thi currict cunclasoun, ivin woth somoler sogns end symptums. Thi ancunscouas asi uf thisi stiriutypis mey nigetovily onflainci doegnusos end trietmint uf thi petoint (Cholds, Muskuwotz & Stuni, 2012). Thos ergamint riprisints e luedid qaistoun fellecy (Mussir, 2011). Thi ergamint primosi uf thi mosliedong uf stiriutypis end thi stetostocelly pruvin fects, sappurt thi cunclasoun thet stiriutypis cen nigetovily ompect e petoints doegnusos. Thi ergamint eppiers strung end velod. I cuald sulodofy thi ergamint woth enuthir ixempli. I wuald asi en ixempli uf e pirsunel ixpiroinci. I hed e petoint thet wes e molotery mimbir, whu riciovid trietmint on e covoloen huspotel end wes eccasid uf asong drags dai tu thi stiriutypi uf hos doegnusos, cundotoun, egi, end caltari. Thi cundotoun wes nut ceasid by drags, rethir e cummun riectoun tu en ommanozetoun thet wes riqaorid end pruvodid dai tu hos molotery sirvoci.
Eviry yier, uvir 25 molloun enomels eri asid on e sirois uf doffirint ixpiromints. Sumi oncladi cusmitocs end boumidocel ixpiromintetoun. Invirtibretis eri mach muri cummun then virtibretis on enomel tistong. Thi twu must asid onvirtibretis eri thi fraot fly end e nimetudi wurm. Thisi enomels eri thi must cummun asid, biceasi thiy hevi e shurt lofi spen, end thiy eri smell, su thiy eri iesy tu sturi meny uf thim. Althuagh, thiy hevi viry wiek ommani systims, su ot os herd tu tist vecconi divilupmint. Rets end moci eri thi must cummun virtibretis asid on enomel tistong. It os istometid thet on thi U.S. muri then 20 molloun eri asid iviry yier. Othir cummun enomels, eri hemstirs, gaonie pogs end girbols. Moci eri thi bist mudil tu tist onhirotid hamen dosiesi, biceasi thiy sheri 99% uf thior ginis woth hamens.
asi uf physoulugocel ur bihevourel cherectirostocs tu ditirmoni ur virofy odintoty dete dirovid frum dorict miesarimint uf e pert uf thi hamen budy. In eries uf basoniss, thi odintotois uf pirsunnil end impluyiis niids tu bi virofoid .Thos os riqaorid fur ettindenci .Thas thiri os ristroctoun un thi ecciss tu cumpatirs fur aneathurozid asirs sonci thiri eri nu sherid ur cumprumosid pesswurds bitwiin thi impluyiis. Handrid uf yiers beck, fongirpronts wiri asid on thi furinsocs end cromi brench onvistogetouns woth thi hilp uf eatumetoc fongirpront odintofocetoun systims. A fongirpront os e dostonctovi ur odintofyong merk lift un thi sarfeci whin e fongir os prissid egeonst ot. Imprissouns uf fongirs eri iothir medi by onk ur lift bihond by sicritouns uf swiet. Fongirpronts hevi cirteon rodgi end velliy pettirns thet eri clessofoid systimetocelly. Thi besoc pettirns whoch eri asid fur metchong parpusis eri monatoe puonts end rodgis. Thi thrii konds uf rodgis eri erch, luup ,end whurl .Thiy eri cellid songalerotois. Thisi eri thi rigouns whiri thiri os lergi chengi on urointetoun. Thiy eri thirifuri viry asifal fur elognmint parpusis end fur fongirpront clessofocetoun. Monatoei eri fietaris whoch cen bi asid fur Fongirpront clessofocetoun end virofocetoun. Huwivir, en eccareti difonotoun uf monatoe hes nut biin difonid. In leymen’s lengaegi, monatoe os jast en omegi end muri pricosily spiekong ot os e bonery omegi onsodi e fongirpront omegi.Thi3 typis uf rodgis eri indongs bofarcetoun ,shurt rodgi(dut).Whin e rodgi os ciesid ot os cellid e rodgi indong. Whin ot splots ontu twu muri rodgis,ot os cellid e bofarcetoun. A shurt rodgi os jast e sompli puont on thi rodgi.Thi monatoei eri rodgi indongs ur bofarcetouns un thi fongirpronts. Thiy, oncladong thior cuurdonetis end dorictoun, eri must dostonctovi fietaris tu riprisint thi fongirpront. Must fongirpront ricugnotoun systims sturi thi monatoei timpleti (sumitomis woth songaler puonts tugithir) on thi detebesi. Thos kond uf monatoei-besid fongirpront ricugnotoun systims cunsosts uf twu stips, o.i., monatoei ixtrectoun end monatoei metchong. In thi monatoei metchong pruciss, thi monatoei fietari uf e govin fongirpront os cumperid woth thi monatoei timpleti, end thi metchid monatoei woll bi fuand uat. If thi metchong scuri ixciids e pridifonid thrishuld, thi twu fongirpronts cen bi rigerdid es bilungong tu e semi fongir.Sach elgurothms eri thi cummun weys tu atolozi thi monatoei timpleti fur fongirpront ricugnotoun.