There are a few sources of stem cells to be considered, including embryos and the adult tissue. The major difference between these cells is their potency, the range of differentiated cells they can generate. Human embryonic stem cells (hESC) are derived from the inner cells mass of the pre-implantation blastocyst stage. They are pluripotent, capable of differentiating into all cells originated from the three primary germ layers (endoderm, mesoderm and ectoderm). On the other hand, adult stem cells are usually multipotent, giving rise only to the major cells types present in their tissue of origin. Yet another source of pluripotent cells are the so-called induced pluripotent stem cells (iPSC), which are created by re-programming so...
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... the number of cells necessary for transplant is very low and the eye easily to accessed and monitored.
Due to stem cells unique properties, they have a huge potential to be utilized in the treatment of regenerative diseases. Nevertheless, there still several unanswered question and aspects that need to be refined for stem cell-based therapy in clinical setting. So far the most prominent cell type utilized in regenerative medicine is the differentiated progeny of hESC, which is more easily obtained than other stem cells. The first clinical trial was performed with hESC-derived RPE for the treatment of macula regeneration. So far, no safety issues were observed and some recovery of the patients was noticed. Most of the success of this trial can be attributed to the particular characteristics of the eye, nevertheless a lot can be learned to be applied in future trials.
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- Introduction Stem cells are a certain type of cells that are classified by their ability to differentiate into different tissues. They are also self- renewing cells. There are three different types of stem cells that have been discovered (Iwamori, Iwamori, & Matzuk M., 2012). The types are embryonic, adult, and induced pluripotent stem cells. Research is currently being done to analyze the potential medical benefits of stem cells. There are also many different ethical questions surrounding stem cells (Shahid & Irshad, 2012).... [tags: tissue, ethics, embryonic, adult, pluripotent]
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