Root Canal Treatment

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The inferior alveolar nerve block is the most frequently used injection technique for achieving local anesthesia in root canal treatment of mandibular teeth. During root canal treatment, profound pulpal anesthesia must be achieved for both patient benefit and making the procedure less stressful for the dentist. The inferior alveolar nerve block has been shown to fail in 44% to 81% of the time (1). This failure could be attributed to several reasons, like anatomical variation of the nerve, decreased local pH, activation of nociceptors like tetrodotoxin, capsaicin-sensitive, transient receptor potential vanilloid type 1 channels (TRPV1 )

MEDIATORS OF PULP INFLAMMATION
Inflammatory changes within the pulp worsen as the carious lesion approximates the pulp. This leads to an influx of neutrophils and release of inflammatory mediators like prostaglandins, interleukins, substance P, bradykinin, and calcitonin gene-related peptide (2). Although pulp inflammation produces a number of inflammatory mediators, prostaglandin is one of the most studied. Generally the mediators sensitize the peripheral nociceptors within the pulp of the affected tooth, which increases pain production and neuronal excitability (2). Prostaglandin is an end-product of arachidonic acid metabolism which is produced via the cyclooxygenase (COX) pathway (3). Prostaglandin leads to activation and sensitization of peripheral nociceptors which in turn leads to sprouting of nerve terminal in the pulp (4). This then upregulates the expression of sodium channels in the nerve cells like tetrodotoxin (TTX) (4). TTX is four times resistant to the blockade of lidocaine and moreover their expression is doubled in the presence of prostaglandins (4). Prostaglandins also act by sensitizing nerve endings to bradykinins and histamines which increases pain and tenderness during inflammation (3).

HOT TOOTH
Hot tooth generally refers to a tooth which has been diagnosed as irreversible pulpitis, with spontaneous, moderate to severe pain, and does not respond to local anaesthesia (2). IANB has a failure rate of 15% in patients with normal tissue (5) whereas it fails in 44-81% of teeth with irreversible pulpitis (6). Essentially, it is not a failure of technique in these cases. The pulpal anaesthesia does not occur due to presence of inflammatory mediators as discussed earlier. Rate of failure in maxillary infiltration is also as high as 30% in teeth with irreversible pulpitis (5). Therefore inability or difficulty to achieve anesthesia in patients with irreversible pulpitis remains as barrier for a successful endodontic treatment.

DRUGS USED AS PREMEDICATION
Several drugs of the NSAID class have been recommended as a premedication to enhance success of local anaesthesia in teeth with hot pulp.

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