The purified nanobodies the with the radiolabeled 99mTechnetium at the His tail was injected into mice. After one hour, their route of clearance checked to know which of these nanobodies is being eliminated from the kidney to the bladder and which one stick in the kidney. Rats were used as model animals instead of mice in this experiment for proper visualization of its organs because of their larger size and because they are unable to produce any antigen against these nanobodies like in other larger mammals. Therefore any distribution ob...
... middle of paper ...
...create humanized nanobodies which will not produce an immune response upon injection into the body (Harmsen and De Haard, 2007; Vincke et al., 2009). The grafting of one or more amino acid(s) from one nanobodies to another in the search of new and exciting properties of Nbs, has encouraged the grafting of whole CDR to understand which of these three CDRs most important. CDR3 of have a very important role in their overall properties of nanobodies. Mutant nanobodies, which had new CDR 3 showed a different pattern when compared to the WT.
Nanobodies are powerful therapeutic tools in imaging to monitor the progression of disease. Nanobodies can be the next generation tool in imaging hence, more research is required to developed novel principles that can be applied to make nanobodies more efficient because improving the imaging quality of nanobodies will be revolutionary.
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