Replacement of Damaged Human Bone Essay

Replacement of Damaged Human Bone Essay

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Developments in nanotechnology and tissue engineering have provided promising ways to repair and replace damaged bone [3, 4]. Poly (sorbital sebacate adipate) (PSSA) is fully biodegradable, thermoplastic aliphatic polyester with biocompatibility and ecological safety. However, it has quite a few drawbacks, such as high elongations and very low thermal stability that prevent its larger commercial applications. The mechanical and thermal instability of PSSA elastomer prevents it from substituting the biodegradable nanomaterials in commercial products [3]. To overcome these drawbacks of PSSA, we have prepared PSSA nanocomposites with organically modified [4].
Human bone tissue is a nanocomposite with both organic and inorganic components. In particular, mineralized hydroxyapatite [Ca10(PO4)6(OH)2,] which is the main inorganic constituent in the bone extracellular matrix. Generally, a perfect tissue-engineered composite should assure several necessary criteria. It should be: biocompatible with biomimetic nanosurface structure and chemistry to minimize the local tissue response while maximizing cell growth and tissue integration; porous to allow cell passage and well-organized exchange of nutrients and wastes; biodegradable with a favorable degradation rate, allowing the composite to provide structural support for initial cell growth and then gradually degrade after new tissue formation; and possess appropriate mechanical properties to support tissue growth under native mechanical loads.[2,5–7].
Polymer nanocomposites are commonly defined as the combination of a polymeric matrix and fillers that have at least one dimension (i.e. length, width or In addition, PSSA/HAP composites have thickness) in the nanometer si...


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...tanding of their biological cell responses.
Here, we reported the synthesis of the SWCNTs-M-HAP/PSSA nanocomposites with varying amount of SWCNTs-M-HAP by hydrothermal insitu method. The friction coefficients of the SWCNTs-M-HAP composites were evaluated by UMT-2 friction tester. In particular, we discuss in detail the effect of several factors including SWCNTs-M-HAP content altering the mechanical, biological, thermal and structural properties of PSSA elastomer. For comparison, the friction coefficient of the pure PSSA elastomer was also investigated. We found that the addition of SWCNTs-M-HAP in composite can decrease the friction coefficient of the composite as compared with the pure PSSA. The friction coefficient of the composite gradually decreased with the increase of SWCNTs-M-HAP content in composite and increased with the increase in applied load.

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