The Relationship Between Endoscopy Results and Serum Tumor Marker Levels in Patients with Dyspepsia

The Relationship Between Endoscopy Results and Serum Tumor Marker Levels in Patients with Dyspepsia

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INTRODUCTION
Gastrointestinal disorders are common diseases and can be diagnosed by endoscopy as a simple and effective procedure. Endoscopy has become a gold standard diagnostic procedure. The main purpose of endoscopist is early diagnosis or exclude gastrointestinal cancer, and to present other gastrointestinal diseases. Carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9) and Alpha fetoprotein (AFP) are used as a marker of gastrointestinal malignancies [1]. CA 19-9 and CEA are antigens related with most of epithelial originated cancers including gastrointestinal cancers [2]. Serum levels of CEA and CA 19-9 are increased in premalignant lesions and early stages of cancer. Also in recent study's measurement of CEA and CA 19-9 in gastric juice by an endogastric capsule, put forth us, we can distinguish between precancerous lesions and cancers or normal cases [3]. The most common used tumor markers; CA 19-9, CEA and AFP are not a beneficial screening method [4]. We aimed to investigate the relationship of gastrointestinal disorders diagnosed by endoscopy with the serum tumor marker levels. Evidence of increased serum tumor marker levels can be an urgent indicator of endoscopy in dyspeptic patients.


MATERİALS AND METHODS
In this study we compared serum tumor marker levels of patients who admitted to Sivrihisar state hospital with gastrointestinal system symptoms and underwent upper gastrointestinal endoscopy with a control group of healthy volunteers. This study was authorized by the local ethics committee. In this way, CA 19-9, CEA and AFP serum levels examined in forty patients who underwent endoscopy and forty healthy volunteers . 5 ml blood sample taken from all of patients and following 20 minutes samples cen...


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...n patients with resectable gastric carcinoma: comparison with CEA. J Surg Oncol. 2001;76:266-271.
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16. Farinati F, Nitti D, Cardin F, et al. CA 19-9 determination in gastric juice: role in identifying gastric cancer and high risk patients. Eur J Cancer Clin Oncol 1988; 24: 923-927.
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