Recriuiting the Most Suitable Laboratory Animals for Food Allergy Modeling

Recriuiting the Most Suitable Laboratory Animals for Food Allergy Modeling

Length: 2176 words (6.2 double-spaced pages)

Rating: Term Papers

Open Document

Essay Preview

During the last few years, most of the societies, all over the world, have been facing a progressive increase of adverse reactions to food. Accordingly, as many as 20-30% of the general population, in the gross, report some two adverse reactions to food components, of which, for the most part, allergic disorders are of considerable concerns owing to their epidemic increase in prevalence and morbidity.
Our understanding of these diseases has enabled the search of therapeutic approaches that can either modulate the sensitization process or impact on allergic mediators and hereby, helping manage allergic symptoms/signs.
Currently, numerous strategies for definitive treatment are being studied, but, most of the clinical studies concerning these new therapies are still, performed in animal models and evidently, not all of them do necessarily offer hope for better treatments in mankind subjects.
The objective of this study was to confirm the sensitizing-operation fulfillment in a wistar model of peanut allergy.
21 out of all 50 rats, were subjected to sensitization, three times, one week apart with crude peanut extract(CPE). Each sensitization attempt was done over 2 consecutive days.
Subsequently, rats were challenged, and anaphylactic reaction parameters including variations in plasma histamine levels, vascular permeability, systemic anaphylaxis scores, and total serum Immunoglobulin E levels were measured.
Taking to account the homeostatic similarities between rat and man, previous studies have suggested that the Brown Norway Rats are the most pertinent model for human allergic diseases. Here, based on our findings, we dare report, for the first time, that the wistar model may even be more predictive of human food-allergic responses....


... middle of paper ...


...iven as means ±SD for each group (21 rats, each).
PN: Peanut, IgE: Immunoglobulin E, W: week, ELISA: Enzyme-Linked Immunosorbent Assay, SD: Standard Deviation, C-: Negative Control, and C+: Positive Control.
Day #0; *P < 0.000 Negative Control vs Positive Control.
Day #32; *P < 0.000 Positive Control vs Negative Control.









Fig. 1: Plasma Histamine Levels 1- w post-sensitization period followed by ig PNE-challenges in both groups of Wistar Rats. Blood specimens for plasma histamine levels were obtained 25-30 min after the second challenge dose administration and were determined by using ELISA. Data have been given as means ± SD for each group (21 rats, each). ). W: week, Ig: intragastric, PNE: Peanut extract, ELISA: Enzyme-Linked Immunosorbent Assay, SD: Standard Deviation, C+: Positive Control; C-: Negative Control. *P < 0.004 Positive Controls vs Naive Rats.

Need Writing Help?

Get feedback on grammar, clarity, concision and logic instantly.

Check your paper »

Essay about A Laboratory Experiment : An Introduction To Lab

- INTRODUCTION TO LAB The laboratory experience gives you the opportunity of seeing, touching, smelling, and hearing (but not tasting!) the structures and materials you learn about in class. What you do in the lab helps you correlate the text and lecture with study of real organisms. You will also gain practical experience in dissections and use of the microscope so you can see structures and relationships with your own eyes. In addition you will perform scientific experiments to help you gain an appreciation of the scientific method....   [tags: Experiment, Microscope slide, Laboratory]

Term Papers
870 words (2.5 pages)

The Laboratory Furniture And Materials Essay

- Common Laboratory Furniture’s and Materials You Must to Know About Laboratories often feature specialized equipment’s designed to make it easy for scientist or researchers to perform their work. One of the most common features on the laboratory, are different types of furniture. Laboratory furniture’s are designed using different types of materials and styles in order to withstand the rigors of the lab environment, thanks to the numerous experiments. The overall style of the furniture in the laboratory is usually determined by the laboratory specialty....   [tags: Chemistry, Laboratory, Corrosion, Laminate]

Term Papers
716 words (2 pages)

Analysis of My Last Duchess and The Laboratory Essay

- “My Last Duchess” and “The Laboratory” are two very diverse yet similar poems written by Robert Browning within the period of three years. In this essay I am going to carefully consider the techniques, language and imagery that Browning uses in these two poems. I am also going to compare the two poems together and how Browning creates the voice and character of the persona in each poem. My Last Duchess was written by Robert Browning in 1842. The poem is a dramatic monologue. The poem flows as there are mid-line pauses (caesura) rather than the poem coming to a halt at the end of each line....   [tags: Robert Browning, The Laboratory]

Term Papers
1017 words (2.9 pages)

Essay on Process Modeling in System Analysis and Design

- Data modeling is used to represent the system visually. It describes how data should be used to meet certain requirements given by the user. (Ref) This helps to ensure that all the requirements of the system have been met. There are numerous types of models used for different reasons, including logical and physical models. Each type of modeling has a specific purpose and is essential to the overall project. Some modeling describes the logic of the system, while others show the flow of information through the system....   [tags: data modeling, logical models]

Term Papers
913 words (2.6 pages)

Uml ( Unified Modeling Language Essay

- UML (Unified Modeling Language) is a universal modeling language in the field of software engineering. It is designed to provide a standard way to visualize the design of a system allowing the programmer to visually see what is required for the software he/she is working on. Many people believe that UML is not important to learn. That it is simply just a time consuming task, and in some cases that is true. But while UML can be time consuming, it can help multiple people understand the essence of a program that is being created....   [tags: Unified Modeling Language, UML diagrams, Flowchart]

Term Papers
769 words (2.2 pages)

Modeling and Role-Modeling Theory Essay

- Holism is the epicenter of Ericson, Tomlin and Swain’s theory of Modeling and Role-Modeling. A newer theory development in nursing, published in 1983 has been integrated into many different university nursing programs as well as in clinical settings (Marriner-Tomey & Alligood, 2006). The theory while simple in concept has a complex combination of other well-known theories in psychology. The theory integrates Abraham Maslow’s higharchy of needs, Erik Erickson’s stages of psychosocial development, Jean Piaget’s cognitive development theory, and Selye and Engle stress response theory (Marriner-Tomey & Alligood, 2006)....   [tags: holism, nursing programs]

Term Papers
761 words (2.2 pages)

Essay on Use of the Unified Modeling Language (UML) for Design

- Unified Modeling Language (UML) is a graphical language used many types of systems models which shows different views of a system being design. The UML is used to describe the conceptual view and process view of an automated ticket-issuing system to be used by passengers on a railway station and for a computer-controlled video-conferencing system used with video, audio, and computer data to participants. Diagrams will show the conceptual and process view of these two systems and have justification for each of the decisions in the design....   [tags: Unified Modeling Language]

Term Papers
1221 words (3.5 pages)

Essay about The Benefits of e-Recruiting

- Technology and the Internet has made many functions easier, faster, and expanded the reach of many processes. Recruiting has benefited greatly from technology. Recruiting has been made easier and the number of potential candidates that could be reached has uncreased; not only individuals actively looking for a job but also inactive candidates willing to accept a better job. Unfortunately, there are unintended consequences that come with the advances in technology. Not everyone can afford access to computers and technology and businesses are not looking for the best candidate that can afford new technology but rather the best candidate....   [tags: Advantages of Online Recruiting]

Term Papers
2304 words (6.6 pages)

Adverse Impact and Recruiting Essay

- Introduction When employers seek new employees, they have a variety of external recruiting methods available from which to choose. The method chosen may depend on such factors as budget, desired applicant characteristics, and type of access to potential employees in the labor market. Recruiting decisions should also consider each method’s potential for adverse impact against certain groups of employees. Adverse impact in employee recruitment or selection occurs when a hiring practice intentionally or unintentionally discriminates against a protected group (CSU-Global, 2013)....   [tags: Recruiting, UGESP, HRM]

Term Papers
1542 words (4.4 pages)

Behavioral Modeling Essay

- Mental and healthcare providers need special awareness of professional boundary crossings and violations. There is a tendency towards encouraging those individuals to behave more empathically and less formally with their patients and clients makes such awareness increasingly important. Professional boundary ethics have been incorporated into the professional codes of many mental and healthcare providers all over the country, but it is important to have continuing education throughout the year (Al Sayyari, Hejaili, Jamal, Shamsi & Tamim, 2010)....   [tags: Ethics ]

Term Papers
2175 words (6.2 pages)