IVF and Preimplantation Genetic Diagnosis: Essay

IVF and Preimplantation Genetic Diagnosis: Essay

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In America alone there are 6.1 million couples coping with infertility (ASRM). In vitro fertilization (IVF) is one of the many assisted reproductive technologies used to help infertile couples achieve pregnancy. Since IVF is costly (the average cost is $12, 400. for one cycle), time consuming and a very emotional situation, many couples have a limited amount of opportunities to commit to the procedure and every step should be taken to maximize the chances of a successful healthy pregnancy. Preimplantation genetic diagnosis, or PGD, is a valuable tool for infertility treatment technology and can facilitate in successful IVF cycles.

The IVF procedure involves removal of eggs from the female's ovaries using an ultrasound guided needle and fertilizing them in a laboratory with the male's sperm. After a certain period of incubation, the fertilized embryos are transferred back into the female's uterus. Successful implantation of a healthy embryo into the uterine lining would need to take place for the woman to become pregnant. PGD enables reproductive endocrinologists to test the chromosomal structure of a three-day embryo prior to transfer to the woman's womb (Werlin). The process begins by using DNA probes to biopsy the embryo at the eight-cell stage of development (Figure A). One cell, or blastomere, is removed for analyzing through a small opening in the outer membrane. It is then tested for chromosomal abnormalities. It is only necessary to access one cell from the embryo because in most cases, all the cells will have the same genetic makeup. The remaining embryo is unharmed and placed in an incubator to resume development. If the testing of the blastomere proves the normal chromosomal makeup, the embryo is then trans...


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Fisher, Jill M., M.S. Preimplantation Genetic Diagnosis. Copyright 2001 Stone Ridge Partners, Inc. http://www.sbivf.com/science/art_serv_aneuploidy.htm

The Infertility Center of St. Louis. General Information on PGD. Image. Copyright 2004 Dr. Sherman J. Silber, M.D. http://www.infertile.com/treatmnt/treats/pgd.htm

Werlin, Lawrence B. Preimplantation Genetic Diagnosis (PGD). Copyright 2003 About, Inc. http://infertility.about.com/library/ifctr/blpgd.htm

Witt, David. Medical Geneticist, Kaiser Permanente. http://abcnews.go.com/sections/Living/DailyNews/PGD ALzheimers020227.html

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